scholarly journals The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling

1998 ◽  
Vol 8 (12) ◽  
pp. 1273-1288 ◽  
Author(s):  
Neil Risch ◽  
Jun Teng
Keyword(s):  
Linkage Disequilibrium ◽  
Case Control ◽  
Human Diseases ◽  
Relative Power ◽  
Dna Pooling ◽  
Family Based ◽  
Control Designs

scholarly journals The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases. II. Individual Genotyping

1999 ◽  
Vol 9 (3) ◽  
pp. 234-241 ◽  
Author(s):  
Jun Teng ◽  
Neil Risch
Keyword(s):  
Relative Efficiency ◽  
Case Control ◽  
Test Statistics ◽  
Dna Pooling ◽  
Test Statistic ◽  
Nonrandom Mating ◽  
Mating Patterns ◽  
Individual Genotyping ◽  
Family Based ◽  
Control Designs

In this paper we consider test statistics based on individual genotyping. For sibships without parents, but with unaffected as well as affected sibs, we introduce a new test statistic (referred to asTDS), which contrasts the allele frequency in affected sibs versus that estimated for the parents from the entire sibship. For sibships without parents, this test is analogous to the TDT and is completely robust to nonrandom mating patterns. The efficiency of the TDS test is comparable to that of the THS test (which compares affected vs. unaffected sibs and was based on DNA pooling), for sibships with one affected child. However, as the number of affected sibs in the sibship grows, the relative efficiency of the TDS test versus theTHS test also increases. For example, for sibships with three affected, one-third fewer families are required; for families with four affected, nearly half as many are required. Thus, when sibships contain multiple affected individuals, theTDS test provides both an increase in power and robustness to nonrandom mating.

scholarly journals Family based and case–control designs reveal an association of TFAP2A in nonsyndromic cleft lip only among Vietnamese population

2021 ◽  
Author(s):  
Duc Minh Nguyen ◽  
Satoshi Suzuki ◽  
Hideto Imura ◽  
Teruyuki Niimi ◽  
Hiroo Furukawa ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Case Control ◽  
Vietnamese Population ◽  
Family Based ◽  
Control Designs

scholarly journals Family-Based versus Unrelated Case-Control Designs for Genetic Associations

PLoS Genetics ◽  
2006 ◽  
Vol 2 (8) ◽  
pp. e123 ◽  
Author(s):  
Evangelos Evangelou ◽  
Thomas A Trikalinos ◽  
Georgia Salanti ◽  
John P. A Ioannidis
Keyword(s):  
Case Control ◽  
Genetic Associations ◽  
Family Based ◽  
Control Designs

scholarly journals Family-based vs. unrelated case-control designs for genetic associations

PLoS Genetics ◽  
2005 ◽  
Vol preprint (2006) ◽  
pp. e123
Author(s):  
Evangelos Evangelou ◽  
Thomas Trikalinos ◽  
Georgia Salanti ◽  
John P. A. Ioannidis
Keyword(s):  
Case Control ◽  
Genetic Associations ◽  
Family Based ◽  
Control Designs

A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry

2010 ◽  
Vol 72 (08/09) ◽  
Author(s):  
J Strohmaier ◽  
J Frank ◽  
J Wendland ◽  
J Schumacher ◽  
J Treutlein ◽  
...  
Keyword(s):  
Case Control ◽  
Family Based

scholarly journals The C242T polymorphism of the gene encoding cytochrome b-245 alpha is not associated with paediatric ischaemic stroke: family-based and case-control study

2010 ◽  
Vol 44 (5) ◽  
pp. 453-458 ◽  
Author(s):  
Paweł Niemiec ◽  
Iwona Żak ◽  
Ewa Emich-Widera ◽  
Anna Balcerzyk ◽  
Ilona Kopyta ◽  
...  
Keyword(s):  
Ischaemic Stroke ◽  
Cytochrome B ◽  
Case Control Study ◽  
Case Control ◽  
Gene Encoding ◽  
C242t Polymorphism ◽  
Family Based ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document