A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry

Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (−1082, −819, and −592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci −819 T > C and −592 A > C for KD cases was observed (Ppermutation= 0.029 and Ppermutation= 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p= 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090–2.443; Ppermutation= 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. {The haplotype CC (−819, −592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987–1.797;p= 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant,p= 0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and −592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study.

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Family-Based Case-Control Approaches to Study the Role of Genetics

Handbook of Statistical Methods for Case-Control Studies ◽

10.1201/9781315154084-26 ◽

2018 ◽

pp. 475-494

Author(s):

Clarice R. Weinberg ◽

Min Shi ◽

David M. Umbach

Keyword(s):

Case Control ◽

Approaches To Study ◽

Family Based

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Decreased oral Epstein-Barr virus DNA loads in patients with nasopharyngeal carcinoma in Southern China: A case-control and a family-based study

Cancer Medicine ◽

10.1002/cam4.1597 ◽

2018 ◽

Vol 7 (7) ◽

pp. 3453-3464 ◽

Cited By ~ 4

Author(s):

Wen-Qiong Xue ◽

Yong-Qiao He ◽

Xiao-Yu Liao ◽

Fang-Fang Li ◽

Ya-Fei Xu ◽

...

Keyword(s):

Nasopharyngeal Carcinoma ◽

Epstein Barr Virus ◽

Southern China ◽

Case Control ◽

Barr Virus ◽

Epstein Barr ◽

Family Based

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Association of HLA Class II Alleles and Haplotypes with Type 1 Diabetes in Tunisian Arabs

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0754-5586 ◽

2018 ◽

Vol 127 (10) ◽

pp. 653-662

Author(s):

Abdelhafidh Hajjej ◽

Wassim Y. Almawi ◽

Mouna Stayoussef ◽

Lasmar Hattab ◽

Slama Hmida

Keyword(s):

Type 1 Diabetes ◽

Association Studies ◽

Class Ii ◽

Correlation Study ◽

Case Control ◽

Linkage Study ◽

Hla Class Ii ◽

Racial Background ◽

Family Based

AbstractThe molecular association of HLA class II with type 1 diabetes (T1DM) was investigated in Tunisian Arabs using 3 kinds of analyses. The first was a case-control association study, using Relative Predispositional Effects method, involved 137 T1DM cases and 258 control subjects. The second was family-based association-linkage study, using Transmission Disequilibrium Test, and covering 50 Tunisian families comprising 73 T1DM patients and 100 parents. The third was a wide correlation study between 4 DRB1 alleles (DRB1*03, *04, *11, *15) and T1DM in 52 countries, using Spearman’s Rho. Results from Case-control and family-based association studies showed that DRB1*03 and DRB1*04 alleles predispose to T1DM in Tunisian Arabs. Conversely, only DRB1*11 was protective for T1DM. DRB1*04-DQB1*03 haplotype was consistently associated positively with T1DM; DRB1*03/DRB1*04 genotype had the highest risk of T1DM development. Compared to DRB1*03, HLA-DRB1*04 was associated with higher T1DM incidence. Thus, the contribution of HLA class II to T1DM genetic susceptibility must be evaluated with regards to specific HLA alleles, genotypes, and haplotypes, and also ethnic and racial background.

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