Improvement in fasting blood sugar, anthropometric measurement and hs-CRP after consumption of epigallocatechin-3-gallate (EGCG) in patients with type 2 diabetes mellitus

2019 ◽  
Vol 50 (2) ◽  
pp. 348-359 ◽  
Author(s):  
Said Hadi ◽  
Meysam Alipour ◽  
Vahideh Aghamohammadi ◽  
Sahar Shahemi ◽  
Fatemeh Ghafouri-Taleghani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Anthropometric Measurement ◽  
Model Assessment ◽  
Content Type ◽  
Hs Crp

Purpose The epigallocatechin gallate (EGCG) effect in diabetes has been investigated in animal studies, but results of clinical trials are inconsistent. Thus, this study aims to evaluate the effects of EGCG supplementation in patients with type 2 diabetes mellitus (T2DM). Design/methodology/approach A total of 50 patients with T2DM were recruited in a double-blind, randomized, placebo-controlled trial. The eligible participants were randomly allocated to EGCG (n = 25) and placebo (n = 25) groups. The EGCG group received two capsules of EGCG (each capsule contained 150 mg; Shari Made®, Iran) and placebo group was administered two capsules of placebo (starch) for eight weeks. A three-day 24-h dietary recall and anthropometric and laboratory measurements were carried out at the beginning and the end of the study. Findings At the end of the trial, weight and body mass index (BMI) were decreased significantly in both groups, but the reduction was not statistically significant between the two groups. Fasting blood sugar decreased significantly in EGCG group. No significant between-group and within-group differences were found in insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index values. The high-sensitive C-reactive protein (hs-CRP) was significantly reduced in the EGCG group (4.13 ± 0.48-3.93 ± 0.50, p = 0.003) compared to baseline. Originality/value This study showed that consuming 300 mg/day of EGCG for eight weeks in patients with T2DM caused a significant decrease in fasting blood glucose, body weight, BMI and hs-CRP compared to baseline. Therefore, the EGCG supplementation may improve glycemic control, anthropometric and inflammation status in T2DM.

scholarly journals Pengaruh Pelayanan Kefarmasian di Rumah pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Wilayah Kota Yogyakarta

2020 ◽  
Vol 10 (2) ◽  
pp. 126
Author(s):  
Nur Rasdianah ◽  
Suwaldi Martodiharjo ◽  
Tri Murti Andayani ◽  
Lukman Hakim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medication Adherence ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Level Of Knowledge ◽  
Sugar Levels

The increasing prevalence of diabetes mellitus (DM) in Indonesia requires participation of all parties including pharmacists. This study aims to determine the impact of the implementation of home pharmacy service guidelines for patients with type 2 diabetes mellitus on the level of knowledge, medication adherence, therapeurical satisfaction and glycemic control. This study used a quasi-experimental design with one group pre-test and post-test design involving 37 patients with type 2 diabetes mellitus who met the requirements of inclusion and exclusion criterias. The Diabetes Knowledge Questionnaire (DKQ-24) and the Diabetes Medication Satisfaction Tool (DMSAT) were used for collecting the data. Patient adherence was measured using a pillcount method and fasting blood sugar levels (FSB) data were obtained from the laboratory results. The study was conducted in two community health centers and patient’s home in the Yogyakarta Municipality area. The data were analysed using Wilcoxon and Spearman test. The results showed the change of the level of knowledge, medication adherence, therapeutic satisfaction and glycemic control before and after intervention of pharmacy services at home. The average decreasing of fasting blood sugar levels 17.09 mg/dL ± 1.43

scholarly journals Detection of Anti-Helicopacter pylori IgG Antibody, Anti-GAD antibody, Anti-Beta islets cell in a sample of serum with type-2 Diabetes mellitus patients

2013 ◽  
Vol 10 (4) ◽  
pp. 1157-1161
Author(s):  
Baghdad Science Journal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Igg Antibody ◽  
H Pylori

We have investigated twenty five patients with type-2 diabetes mellitus aged (35-60) years and fifteen healthy persons as control group to detect Anti-Helicobacter pylori IgG antibody. All studied groups were carried out to measure fasting blood sugar, anti- Glutamic acid decarboxylase (GAD), anti-? islets cells antibody by IFAT, Anti-H. pylori IgG antibody by ELISA technique. There was significant elevation in the concentration of fasting blood sugar than in control group (P < 0.05), the patients had negative results for anti-GAD antibody and anti- ? islets cells antibody, there were significant differences (P < 0.05) of anti-H. pylori IgG antibody in 28 % of patients had type-2 diabetes than control group. This lead to suggestion that type -2 diabetes mellitus patients are more susceptible to H. pylori .

scholarly journals Prevalence of depression in patients with type 2 diabetes mellitus and its association with fasting blood sugar levels, in an urban area of Kancheepuram district, Tamil Nadu

2017 ◽  
Vol 4 (9) ◽  
pp. 3399 ◽  
Author(s):  
Anantha Eashwar V. M ◽  
Gopalakrishnan S. ◽  
Umadevi R.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Poor Prognosis ◽  
Severe Depression ◽  
Fasting Blood Sugar ◽  
Prevalence Of Depression ◽  
Sugar Levels

Background: Type 2 diabetes mellitus (T2DM) and depressive disorders are among the major health problems in our community. Chronic medical conditions, like diabetes are affectively stressful for patients and may influence pathophysiologic mechanisms as well as mood. This can lead to depression and poor prognosis of T2DM. This study was done to assess the prevalence of depression among T2DM patients and its association with glycemic control.Methods: This descriptive cross sectional study was carried out among 300 T2DM patients attending Urban Health Training Center (UHTC), Anakaputhur, which belongs to the urban field practice area of our institution. Fasting Blood Sugar levels (FBS) were assessed retrospectively from their medical records; and they were screened for depression by administering the nine items, “Patient Health Questionnaire - 9”.Results: Of the 300 T2DM patients, 54% were females. The mean age of the participants was 53±9.7 years. 31% of the study participants had fasting blood sugar (FBS) levels above 125 mg/dl. Depression was present in 39.7% of the individuals, among which, 17.3% had mild depression, 13% had moderate depression, 6.7% had moderately severe depression and 2.7% had severe depression. Depression was found to be significantly associated with increasing fasting blood sugar levels, diabetic complications, female gender and diabetic treatment.Conclusions: This study shows that depression is highly prevalent among T2DM patients and is associated with poor prognosis, as reflected by poor glycemic control (FBS) and the occurrence of diabetic complications. So screening and counselling for depression among T2DM patients have to be carried out for optimum control and treatment of T2DM.

scholarly journals HUBUNGAN KEPATUHAN DIET DENGAN KADAR GULA DARAH PUASA PADA PASIEN DIABETES MELITUS TIPE 2

2020 ◽  
Vol 11 (1) ◽  
pp. 102
Author(s):  
Nur Salma ◽  
Fadli Fadli ◽  
Abd. Hayat Fattah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Diet Therapy ◽  
Fasting Blood Sugar ◽  
Dietary Therapy ◽  
Diet Adherence ◽  
A Value

Type 2 diabetes mellitus is a chronic disease that cannot be cured but can be prevented and controlled through the 4 pillars of diabetes mellitus management which includes education, diet therapy, exercise, and medication. Diet therapy is used to help type 2 sufferers improve their eating habits so they can control glucose, fat, and blood pressure levels so that the success of dietary therapy depends on the patient's compliance with diet. The purpose of this study was to determine the correlation between diet adherence with fasting blood sugar levels in patients with type 2 diabetes mellitus. The design of this study used a correlation analysis method with cross sectional approach. The sampling technique is total sampling with a total sample of 28 respondents. Data were collected using a questionnaire and analyzed by linear regression test. The results of the study of dietary compliance based on the number of calories with a value of p = 0.042, adherence to the diet schedule with a value of p = 0.007 and adherence to the type of food diet p value = 0.002. This shows that there is an influence of diet adherence to the level of GDP of patients with type 2 diabetes mellitus at the Lancirang Health Center in 2020 while the percentage of influence is 14.4% as indicated by the value of R square = 0.144. So that in the process of reducing fasting blood sugar, patients or patients should change their behavior, especially on diet compliance based on the number of calories in their food.

Association between Glycemic Indices, hs-CRP and Anthropometrical Parameters of Patients with Type 2 Diabetes Mellitus

2018 ◽  
Vol 55 (2) ◽  
pp. 187
Author(s):  
Hetal N. Parekh ◽  
Subhadra Mandalika ◽  
Suresh Mehtalia
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Composition ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Poor Glycemic Control ◽  
Dietary Practices ◽  
Hs Crp

Risk of obesity, inflammatory conditions and poor glycemic control have been reported to be lower among vegetarian T2DM patients due to their lower intake of fat, high intake of dietary fiber and micronutrients. However, several factors influence dietary practices and thereby glycemic control among patients which demands in depth observation. A cross-sectional observational study to examine the association between body composition, glycemic control and hs-CRP of Type 2 Diabetes Mellitus (T2DM) patients was conducted on 160 uncontrolled T2DM patients including 81 (50.6%) vegetarians and 79 (49.4%) non-vegetarians with mean age of 49.8±7.2 years. They were assessed for body composition using anthropometry. Biochemical parameters [(Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS), Glycosylated Hemoglobin (HbA1c) and high sensitive C Reactive Protein (hs-CRP)] were obtained from their case files. Data were analysed using SPSS software for Windows (Version 16.0, 2007, SPSS Inc, Chicago IL). Anthropometric indices (weight, BMI, WC, hip circumference, WHR, BMR, visceral fat) and hs-CRP levels were significantly higher in vegetarians than non-vegetarians (p&lt;0.05). However, there was no significant difference in FBS, PPBS and HbA1C between the two groups (p&gt;0.05). Vegetarian participants had higher hs-CRP (≤3.0 mg/dl) and poor glycemic control. A positive correlation of anthropometry indices with hs-CRP was also observed among the participants (p&lt;0.05). Dietary practices of vegetarians might vary across the populations and communities and hence there is a strong need to strictly consider these differences in the development of dietary strategies for T2DM.

Correlation of Serum Magnesium with Insulin Resistance in North Indian Adult Population

2020 ◽  
Vol 16 (3) ◽  
pp. 254-261
Author(s):  
Geeta Shamnani ◽  
Shekhawat S. Bhartiy ◽  
Rekha Jiwane ◽  
Vani Gupta ◽  
Narsingh Verma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Magnesium ◽  
Insulin Level ◽  
Fasting Blood Sugar ◽  
Apparently Healthy

Background: Globalization has lead to such lifestyle changes which have produced increase in incidence and prevalence of Type 2 Diabetes Mellitus (T2DM). Magnesium is found to have some role in glucose metabolism. The aim of this study was to investigate the relationship between serum magnesium levels with insulin resistance in apparently healthy adults. Objective: The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance. Materials and Methods: The study was a cross-sectional study which was population based. Total 130 apparently healthy adults of age between 25-65 years, were recruited with prior ethical approval and written informed consent. Results: Serum magnesium was found to be negatively correlated with fasting blood sugar (FBS), insulin level and HOMA-IR. Co-relation of magnesium with FBS (r = -0.55, p<0.0001), insulin (r = -0.45, p< 0.0001) and HOMA-IR (r = -0.52, p<0.0001) was significant. Conclusion: As per findings it was concluded that serum magnesium was found to have significant negative correlation with fasting blood sugar (FBS), insulin and HOMA-IR, thus hypomagnesaemia can be suggested to be one of the important predictor of type 2 diabetes mellitus.

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