A Novel Macrophage-Based Microrobot Bearing Multiple Smart Nanotherapeutics for Targeting and Drug Delivery to Solid Tumors* This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) 2016M3A9E9941514

2018 ◽  
Author(s):  
Van Du Nguyen ◽  
Viet Ha Le ◽  
Chang-Sei Kim ◽  
Jiwon Han ◽  
Jong-Oh Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Medical Technology ◽  
Technology Development ◽  
Development Program ◽  
Korean Government

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

scholarly journals Current Status of Ceramic Gas Turbine (CGT302)

1998 ◽  
Author(s):  
Hirotake Kobayashi ◽  
Tetsuo Tatsumi ◽  
Takashi Nakashima ◽  
Isashi Takehara ◽  
Yoshihiro Ichikawa
Keyword(s):  
Gas Turbine ◽  
Thermal Efficiency ◽  
Technology Development ◽  
Development Program ◽  
Point Of View ◽  
Current Status ◽  
Fiscal Year ◽  
Inlet Temperature ◽  
Development Organization ◽  
New Energy

In Japan, from the point of view of energy saving and environmental protection, a 300kW Ceramic Gas Turbine (CGT) Research and Development program started in 1988 and is still continuing as a part of “the New Sunshine Project” promoted by the Ministry of International Trade and Industry (MITT). The final target of the program is to achieve 42% thermal efficiency at 1350°C of turbine inlet temperature (TIT) and to keep NOx emissions below present national regulations. Under contract to the New Energy and Industrial Technology Development Organization (NEDO), Kawasaki Heavy Industries, Ltd. (KHI) has been developing the CGT302 with Kyocera Corporation and Sumitomo Precision Products Co., Ltd. By the end of the fiscal year 1996, the CGT302 achieved 37.0% thermal efficiency at 1280°C of TIT. In 1997, TIT reached 1350°C and a durability operation for 20 hours at 1350°C was conducted successfully. Also fairly low NOx was proved at 1300°C of TIT. In January 1998, the CGT302 has achieved 37.4% thermal efficiency at 1250°C TIT. In this paper, we will describe our approaches to the target performance of the CGT302 and current status.

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