A parallelizable technique for 3D simulations of cardiac electrical propagation based on sub-cellular physiology

Nanomaterials have become part of our daily lives, particularly nanoparticles contained in food, water, cosmetics, additives and textiles. Nanoparticles interact with organisms at the cellular level. The cell membrane is the first protective barrier against the potential toxic effect of nanoparticles. This first contact, including the interaction between the cell membranes -and associated proteins- and the nanoparticles is critically reviewed here. Nanoparticles, depending on their toxicity, can cause cellular physiology alterations, such as a disruption in cell signaling or changes in gene expression and they can trigger immune responses and even apoptosis. Additionally, the fundamental thermodynamics behind the nanoparticle-membrane and nanoparticle-proteins-membrane interactions are discussed. The analysis is intended to increase our insight into the mechanisms involved in these interactions. Finally, consequences are reviewed and discussed.

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Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases

Current Molecular Medicine ◽

10.2174/1566524016666161223105555 ◽

2017 ◽

Vol 16 (10) ◽

pp. 906-913 ◽

Cited By ~ 8

Author(s):

Q. Nie ◽

X.-D. Gong ◽

M. Liu ◽

D. Li

Keyword(s):

Human Diseases ◽

Cellular Physiology

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The formation of star clusters - II. 3D simulations of magnetohydrodynamic turbulence in molecular clouds

Monthly Notices of the Royal Astronomical Society ◽

10.1111/j.1365-2966.2007.12371.x ◽

2007 ◽

Vol 382 (1) ◽

pp. 73-94 ◽

Cited By ~ 48

Author(s):

D. A. Tilley ◽

R. E. Pudritz

Keyword(s):

Molecular Clouds ◽

Star Clusters ◽

Magnetohydrodynamic Turbulence ◽

3D Simulations

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3D Simulation-Based Acoustic Wave Resonator Analysis and Validation Using Novel Finite Element Method Software

Sensors ◽

10.3390/s21082715 ◽

2021 ◽

Vol 21 (8) ◽

pp. 2715

Author(s):

Ruth Yadira Vidana Morales ◽

Susana Ortega Cisneros ◽

Jose Rodrigo Camacho Perez ◽

Federico Sandoval Ibarra ◽

Ricardo Casas Carrillo

Keyword(s):

Finite Element ◽

High Performance ◽

Cloud Services ◽

3D Simulation ◽

3D Simulations ◽

Acoustic Resonators ◽

Analysis And Design ◽

Wave Resonator ◽

Film Bulk ◽

Simulation Results

This work illustrates the analysis of Film Bulk Acoustic Resonators (FBAR) using 3D Finite Element (FEM) simulations with the software OnScale in order to predict and improve resonator performance and quality before manufacturing. This kind of analysis minimizes manufacturing cycles by reducing design time with 3D simulations running on High-Performance Computing (HPC) cloud services. It also enables the identification of manufacturing effects on device performance. The simulation results are compared and validated with a manufactured FBAR device, previously reported, to further highlight the usefulness and advantages of the 3D simulations-based design process. In the 3D simulation results, some analysis challenges, like boundary condition definitions, mesh tuning, loss source tracing, and device quality estimations, were studied. Hence, it is possible to highlight that modern FEM solvers, like OnScale enable unprecedented FBAR analysis and design optimization.

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Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

Journal of The Royal Society Interface ◽

10.1098/rsif.2014.0352 ◽

2014 ◽

Vol 11 (97) ◽

pp. 20140352 ◽

Cited By ~ 99

Author(s):

Alfonso Bueno-Orovio ◽

David Kay ◽

Vicente Grau ◽

Blanca Rodriguez ◽

Kevin Burrage

Keyword(s):

Structural Heterogeneity ◽

Biological Tissues ◽

Tissue Level ◽

Fractional Diffusion ◽

Diffusion Models ◽

Excitable Media ◽

Research Fields ◽

Dispersion Of Repolarization ◽

Electrical Propagation

Impulse propagation in biological tissues is known to be modulated by structural heterogeneity. In cardiac muscle, improved understanding on how this heterogeneity influences electrical spread is key to advancing our interpretation of dispersion of repolarization. We propose fractional diffusion models as a novel mathematical description of structurally heterogeneous excitable media, as a means of representing the modulation of the total electric field by the secondary electrical sources associated with tissue inhomogeneities. Our results, analysed against in vivo human recordings and experimental data of different animal species, indicate that structural heterogeneity underlies relevant characteristics of cardiac electrical propagation at tissue level. These include conduction effects on action potential (AP) morphology, the shortening of AP duration along the activation pathway and the progressive modulation by premature beats of spatial patterns of dispersion of repolarization. The proposed approach may also have important implications in other research fields involving excitable complex media.

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