Too hot, too fast! Using the thermal grill illusion to explore dynamic thermal perception

2018 ◽  
Author(s):  
Shriniwas Patwardhan ◽  
Anzu Kawazoe ◽  
David Kerr ◽  
Masashi Nakatani ◽  
Yon Visell
Keyword(s):  
Thermal Perception ◽  
Thermal Grill Illusion

Central neuropathic pain in multiple sclerosis is associated with impaired innocuous thermal pathways and neuronal hyperexcitability

Pain Medicine ◽  
2021 ◽  
Author(s):  
Michal Rivel ◽  
Anat Achiron ◽  
Mark Dolev ◽  
Yael Stern ◽  
Gaby Zeilig ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neuropathic Pain ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Sensory Testing ◽  
Cross Sectional ◽  
Central Neuropathic Pain ◽  
Body Regions ◽  
Thermal Grill Illusion

Abstract Objective About a third of patients with multiple sclerosis (MS) suffer from chronic and excruciating central neuropathic pain (CNP). The mechanism underlying CNP in MS is not clear, since previous studies are scarce and their results are inconsistent. Our aim was to determine whether CNP in MS is associated with impairment of the spinothalamic-thalamocortical pathways (STTCs) and/or increased excitability of the pain system. Design Cross sectional study Setting General hospital Subjects 47 MS patients with CNP, 42 MS patients without CNP, and 32 healthy controls. Methods Sensory testing included the measurement of temperature, pain, and touch thresholds and the thermal grill illusion (TGI) for evaluating STTCs function, and hyperpathia and allodynia as indicators of hyperexcitability. CNP was characterized using interviews and questionnaires. Results The CNP group had higher cold and warm thresholds (p < 0.01), as well as higher TGI perception thresholds (p < 0.05), especially in painful body regions compared to controls, whereas touch and pain thresholds values were normal. The CNP group also had a significantly greater prevalence of hyperpathia and allodynia. Regression analysis revealed that whereas presence of CNP was associated with a higher cold threshold, CNP intensity, and the number of painful body regions were associated with allodynia and hyperpathia, respectively. Conclusions CNP in MS is characterized by a specific impairment of STTC function; the innocuous thermal pathways, and by pain hyperexcitability. Whereas CNP presence is associated with STTC impairment, its severity and extent are associated with pain hyperexcitability. Interventions that reduce excitability level may therefore mitigate CNP severity.

The influence of air-conditioning managerial scheme in hybrid-ventilated classrooms on students’ thermal perception

2014 ◽  
Vol 24 (6) ◽  
pp. 761-770 ◽  
Author(s):  
Chen-Peng Chen ◽  
Ruey-Lung Hwang ◽  
Weiwei Liu ◽  
Wen-Mei Shih ◽  
Shih-Yin Chang
Keyword(s):  
Air Conditioning ◽  
Thermal Perception

scholarly journals The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christopher J. Esh ◽  
Bryna C. R. Chrismas ◽  
Alexis R. Mauger ◽  
Anissa Cherif ◽  
John Molphy ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Skin Temperature ◽  
Effect Size ◽  
Mixed Models ◽  
Thermal Perception ◽  
Random Coefficient Models ◽  
Healthy Humans ◽  
Within Subjects ◽  
Thermogenic Response

AbstractWhether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.

scholarly journals Validation of a Brazilian quantitative sensory testing (QST) device for the diagnosis of small fiber neuropathies

2011 ◽  
Vol 69 (6) ◽  
pp. 943-948 ◽  
Author(s):  
Pedro Schestatsky ◽  
Luciana Cadore Stefani ◽  
Paulo Roberto Sanches ◽  
Danton Pereira da Silva Júnior ◽  
Iraci Lucena Silva Torres ◽  
...  
Keyword(s):  
Quantitative Sensory Testing ◽  
Stimulus Change ◽  
Heat Pain ◽  
Thermal Perception ◽  
Sensory Testing ◽  
Brazilian Sample ◽  
Small Fiber ◽  
Normal Individuals ◽  
Nociceptive Pathway

Quantitative sensory testing (QST) is defined as the determination of thresholds for sensory perception under controlled stimulus. Our aim was to validate a new QST device for Brazilian sample. In 20 healthy adults, thermoalgesic thresholds were assessed using a QST prototype (Heat Pain Stimulator-1.1.10; Brazil). A 30 × 30 mm² thermode with a 1°C/s stimulus change rate were applied. Thresholds of three consecutive stimuli were averaged in two different sessions separated by at least two weeks. Additionally long thermal heat pain stimulus was performed. To evaluate the consistency of our method we also analyzed 11 patients with small fiber neuropathy. Results showed good reproducibility of thermal perception thresholds in normal individuals and plausible abnormal thresholds in patients. We conclude that our QST device is reliable when analyzing the nociceptive pathway in controls and patients.

Interferences of urban form on human thermal perception

2019 ◽  
Vol 653 ◽  
pp. 1067-1076 ◽  
Author(s):  
Eduardo L. Krüger ◽  
Tamiris Costa
Keyword(s):  
Urban Form ◽  
Thermal Perception

Outdoor human thermal perception in various climates: A comprehensive review of approaches, methods and quantification

2018 ◽  
Vol 631-632 ◽  
pp. 390-406 ◽  
Author(s):  
Oded Potchter ◽  
Pninit Cohen ◽  
Tzu-Ping Lin ◽  
Andreas Matzarakis
Keyword(s):  
Thermal Perception ◽  
Comprehensive Review

scholarly journals Vasopressin at Central Levels and Consequences of Dehydration

2016 ◽  
Vol 68 (Suppl. 2) ◽  
pp. 19-23 ◽  
Author(s):  
Daniel G. Bichet
Keyword(s):  
Animal Studies ◽  
Transient Receptor Potential ◽  
Animal Experiments ◽  
Extracellular Fluid ◽  
Receptor Potential ◽  
Circumventricular Organ ◽  
Thermal Perception ◽  
Trpv1 Channel ◽  
Vasopressin Release ◽  
Transient Receptor

Disorders of water balance are a common feature of clinical practice. An understanding of the physiology and pathophysiology of central vasopressin release and perception of thirst is the key to diagnosis and management of these disorders. Mammals are osmoregulators; they have evolved mechanisms that maintain extracellular fluid osmolality near a stable value, and, in animal studies, osmoregulatory neurons express a truncated delta-N variant of the transient receptor potential vannilloid (TRPV1) channel involved in hypertonicity and thermal perception while systemic hypotonicity might be perceived by TRPV4 channels. Recent cellular and optogenetic animal experiments demonstrate that, in addition to the multifactorial process of excretion, circumventricular organ sensors reacting to osmotic pressure and angiotensin II, subserve genesis of thirst, volume regulation and behavioral effects of thirst avoidance.

scholarly journals Thermal perception of Brazilian elderly in an air-conditioned room: a first approach

2016 ◽  
Vol 7 (4) ◽  
pp. 202 ◽  
Author(s):  
Fabiana Padilha Montanheiro ◽  
João Roberto Gomes de Faria
Keyword(s):  
Thermal Perception

Apesar do envelhecimento da população de forma geral e, em particular, no Brasil, não há até o momento pesquisas sobre a percepção térmica do idoso no país. As informações disponíveis são baseadas em estudos realizados em climas diversos dos brasileiros. O objetivo do presente trabalho foi avaliar se existem alterações significativas na percepção térmica de idosos em relação à de indivíduos mais jovens. Numa sala com ar condicionado foram medidas suas variáveis térmicas e aplicado um questionário a uma amostra de idosos. As respostas a questões sobre percepção térmica relatada pelos sujeitos (PT), conforto e preferência térmica, aceitabilidade e tolerância pessoal foram relacionadas com as respectivas temperaturas operacionais e essas com as calculadas pelo PMV (referência para não idosos). A temperatura operativa média de neutralidade (PT = 0) foi menor que a calculada pelo PMV, ou seja, menor do que a preferida por não idosos; além disso, a faixa de temperatura operativa de conforto térmico de idosos é também maior que a de não idosos. Os resultados divergem, em princípio, dos encontrados na bibliografia internacional, ao encontrar temperaturas de conforto para idosos menores do que para não idosos, mas eles podem ser amparados em trabalhos mais recentes, os quais envolvem termometria circadiana. Outras respostas ao questionário mostram que o PMV não é um bom previsor de condições de conforto térmico para idosos. Como este é o primeiro trabalho sobre o tema no Brasil, ele abre uma discussão e convida pesquisadores a realizar estudos similares para sua validação.

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