The Research aims to determine the influence of inflation, currency exchange rate, interest rate that affect net asset value of protected Islamic mutual fund from 2014-2018 in Indonesia partially and simultaneously. The research also uses quantitative approach and multiple regression analysis technique. The sample used for this research is obtained from monthly statistic data of Bank Indonesia, Otoritas Jasa Keuangan, and Pusat data kontan which had been published online from January 2014 to Desember 2018, so there are 60 samples taken for this reserch. The variabels of this research include inflation (X1), currency exchange rate (X2), interest rate (X3), and net asset value of protected Islamic mutual fund (Y). The result of this research shows that partially, the inflation affect Net Asset Value of Protected Islamic Mutual Fund from 2014-2018 in Indonesia insignificantly, currency exchange rate affect Net Asset Value of Protected Islamic Mutual Fund from 2014-2018 in Indonesia significantly, and interest rate affect Net Asset Value of Protected Islamic Mutual Fund from 2014-2018 in Indonesia significantly. Simultaneously, all independent variables affect Net Asset Value of Protected Islamic Mutual Fund from 2014-2018 in Indonesia significantly.Keywords: Macroeconomic, Inflation, InterestRate, Currency Exchange Rate, Net Asset Value, Protected Islamic Mutual Fund