The development of artificial intelligence (AI) has accelerated the digital revolution and has had an enormous impact on all aspects of life. Work patterns are starting to change, and cooperation between humans and machines, currently humans and various forms of AI, is becoming crucial. There are advantages and some threats related to these new forms of human–AI collaboration. It is necessary to base this collaboration on ethical principles, ensuring the autonomy of humans over technology. This will create trust, which is indispensable for the fruitful use of AI. This requires an adequate regulatory framework: one that is future proof, anticipates how AI will develop, takes a risk-based approach and implements ex ante assessment as a tool to avoid unintended consequences. Furthermore, we need human oversight of the development of AI, supported by inter-institutional partnerships. But first we need to create the conditions for the development of AI digital literacy.