The chapter is aimed at the problem of use and adjustment of system software of multiprocessor computing systems. The main principles of the Linux operating system were considered, which were necessary when constructing a multiprocessor computing system. These studies also cover new ways to remotely access the memory of processor systems through the use of RDMA technology for InfiniBand technology. Thus, it has been shown that the RDMA principle, together with the formation of a separate computing network in the data interchange environment, and the implementation of VLAN mechanisms, allowed the data transmission among nodes memory of the multiprocessor computing system without additional buffering. This approach does not require the active OS operation, libraries, or applications on those nodes of the system which memory is requested.