Multi-agent systems (MAS), consist of a number of autonomous agents, which interact with one-another. To make such interactions successful, they will require the ability to cooperate, coordinate, and negotiate with each other. From a theoretical point of view such systems require a hybrid approach involving game theory, artificial intelligence, and distributed programming. On the other hand, biology offers a number of inspirations showing how these interactions are effectively realized in real world situations. Swarm organizations, like ant colonies or bird flocks, provide a spectrum of metaphors offering interesting models of collective problem solving. Immune system, involving complex relationships among antigens and antibodies, is another example of a multi-agent and swarm system. In this chapter an application of so-called clonal selection algorithm, inspired by the real mechanism of immune response, is proposed to solve the problem of learning strategies in the pursuit-evasion problem.