Evaluating Dynamic Effects of Copy Number Alterations on Gene Expression Using a Single Transcription Model

2012 ◽  
Vol 59 (10) ◽  
pp. 2726-2736 ◽  
Author(s):  
Fang-Han Hsu ◽  
E. Serpedin ◽  
Yidong Chen ◽  
E. R. Dougherty
Keyword(s):  
Gene Expression ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Dynamic Effects

DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up

2016 ◽  
Vol 39 (6) ◽  
pp. 545-558 ◽  
Author(s):  
Elisabetta Bigagli ◽  
Carlotta De Filippo ◽  
Cinzia Castagnini ◽  
Simona Toti ◽  
Francesco Acquadro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Copy Number ◽  
Disease Free Survival ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Free Survival ◽  
Dna Copy Number Alterations ◽  
Disease Free

scholarly journals Integrated analysis of copy number alterations and gene expression: a bivariate assessment of equally directed abnormalities

2009 ◽  
Vol 25 (24) ◽  
pp. 3228-3235 ◽  
Author(s):  
Martin Schäfer ◽  
Holger Schwender ◽  
Sylvia Merk ◽  
Claudia Haferlach ◽  
Katja Ickstadt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Copy Number ◽  
Integrated Analysis ◽  
Copy Number Alterations

scholarly journals A pan-cancer atlas of transcriptional dependence on DNA methylation and copy number aberrations

2020 ◽  
Author(s):  
Christian Fougner ◽  
Elen K. Höglander ◽  
Tonje G. Lien ◽  
Therese Sørlie ◽  
Silje Nord ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Copy Number ◽  
Normal Cell ◽  
Tumor Heterogeneity ◽  
Copy Number Alterations ◽  
Cell Of Origin ◽  
Online Tool ◽  
Copy Number Aberrations ◽  
Pan Cancer

AbstractCancer transcriptomes are shaped by genetic and epigenetic features, such as DNA methylation and copy number aberrations. Knowledge of the relationships between gene expression and such features is fundamental to understanding the basis of tumor phenotypes. Here, we present a pan-cancer atlas of transcriptional dependence on DNA methylation and copy number aberrations (PANORAMA). Our analyses suggest that copy number alterations are a central driver of inter-tumor heterogeneity, while the majority of expression-methylation associations found in cancer are a reflection of cell-of-origin and normal cell admixture. The atlas is made available through an online tool at https://pancancer.app.

scholarly journals Functional profiling and gene expression analysis of chromosomal copy number alterations

2007 ◽  
Vol 1 (10) ◽  
pp. 432-435 ◽  
Author(s):  
Lucía Conde ◽  
David Montaner ◽  
Jordi Burguet- Castell ◽  
Joaquín Tárraga ◽  
Fátima Al- Shahrour ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Analysis ◽  
Copy Number ◽  
Gene Expression Analysis ◽  
Copy Number Alterations ◽  
Functional Profiling ◽  
Chromosomal Copy Number ◽  
Chromosomal Copy
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