Development of a Stroke Risk Assessment Model for a Small Population in South Kerala using Logistic Regression

Author(s):  
R S Jeena ◽  
A Sukeshkumar
2021 ◽  
Vol 9 ◽  
Author(s):  
Qiao-Ying Xie ◽  
Ming-Wei Wang ◽  
Zu-Ying Hu ◽  
Cheng-Jian Cao ◽  
Cong Wang ◽  
...  

Aim: Metabolic syndrome (MS) screening is essential for the early detection of the occupational population. This study aimed to screen out biomarkers related to MS and establish a risk assessment and prediction model for the routine physical examination of an occupational population.Methods: The least absolute shrinkage and selection operator (Lasso) regression algorithm of machine learning was used to screen biomarkers related to MS. Then, the accuracy of the logistic regression model was further verified based on the Lasso regression algorithm. The areas under the receiving operating characteristic curves were used to evaluate the selection accuracy of biomarkers in identifying MS subjects with risk. The screened biomarkers were used to establish a logistic regression model and calculate the odds ratio (OR) of the corresponding biomarkers. A nomogram risk prediction model was established based on the selected biomarkers, and the consistency index (C-index) and calibration curve were derived.Results: A total of 2,844 occupational workers were included, and 10 biomarkers related to MS were screened. The number of non-MS cases was 2,189 and that of MS was 655. The area under the curve (AUC) value for non-Lasso and Lasso logistic regression was 0.652 and 0.907, respectively. The established risk assessment model revealed that the main risk biomarkers were absolute basophil count (OR: 3.38, CI:1.05–6.85), platelet packed volume (OR: 2.63, CI:2.31–3.79), leukocyte count (OR: 2.01, CI:1.79–2.19), red blood cell count (OR: 1.99, CI:1.80–2.71), and alanine aminotransferase level (OR: 1.53, CI:1.12–1.98). Furthermore, favorable results with C-indexes (0.840) and calibration curves closer to ideal curves indicated the accurate predictive ability of this nomogram.Conclusions: The risk assessment model based on the Lasso logistic regression algorithm helped identify MS with high accuracy in physically examining an occupational population.


2020 ◽  
Author(s):  
Qiao-Ying Xie ◽  
Ming-Wei Wang ◽  
Zu-Ying Hu ◽  
Yan-Ming Chu ◽  
Cheng-Jian Cao ◽  
...  

Abstract Background: Metabolic syndrome (MS) screening is important for the early detection of occupational population. This study aimed to screen out biomarkers related to MS and establish a risk assessment and prediction model for the routine physical examination of an occupational population.Methods: The least absolute shrinkage and selection operator (Lasso) regression algorithm of machine learning was used to screen biomarkers related to MS. Then, the accuracy of the logistic regression model was further verified based on the Lasso regression algorithm. Finally, the screened biomarkers were used to establish a logistic regression model and calculate the odds ratio (OR) of the corresponding biomarkers. Results: A total of 2844 occupational workers were included, and 10 biomarkers related to MS were screened. The area under the curve (AUC) value for non-Lasso and Lasso regression was 0.652 and 0.907, respectively. The established risk assessment model revealed that the main risk factors were basophil absolute count (OR: 3.38), platelet packed volume (OR: 2.63), leukocyte count (OR: 2.01), red blood cell count (OR: 1.99), and alanine aminotransferase level (OR: 1.53). Conclusion: The risk assessment model based on the Lasso regression algorithm helped identify Metabolic syndrome with high accuracy in physically examining an occupational population.


Fire ◽  
2021 ◽  
Vol 4 (3) ◽  
pp. 57
Author(s):  
Zhen Zhang ◽  
Leilei Wang ◽  
Naiting Xue ◽  
Zhiheng Du

The increasing frequency of active fires worldwide has caused significant impacts on terrestrial, aquatic, and atmospheric systems. Polar regions have received little attention due to their sparse populations, but active fires in the Arctic cause carbon losses from peatlands, which affects the global climate system. Therefore, it is necessary to focus on the spatiotemporal variations in active fires in the Arctic and to assess the fire risk. We used MODIS C6 data from 2001 to 2019 and VIIRS V1 data from 2012 to 2019 to analyse the spatiotemporal characteristics of active fires and establish a fire risk assessment model based on logistic regression. The trends in active fire frequency based on MODIS C6 and VIIRS V1 data are consistent. Throughout the Arctic, the fire frequency appears to be fluctuating and overall increasing. Fire occurrence has obvious seasonality, being concentrated in summer (June–August) and highest in July, when lightning is most frequent. The frequency of active fires is related to multiple factors, such as vegetation type, NDVI, elevation, slope, air temperature, precipitation, wind speed, and distances from roads and settlements. A risk assessment model was constructed based on logistic regression and found to be accurate. The results are helpful in understanding the risk of fires in the Arctic under climate change and provide a scientific basis for fire prediction and control and for reducing fire-related carbon emissions.


2010 ◽  
Vol 151 (34) ◽  
pp. 1365-1374 ◽  
Author(s):  
Marianna Dávid ◽  
Hajna Losonczy ◽  
Miklós Udvardy ◽  
Zoltán Boda ◽  
György Blaskó ◽  
...  

A kórházban kezelt sebészeti és belgyógyászati betegekben jelentős a vénásthromboembolia-rizikó. Profilaxis nélkül, a műtét típusától függően, a sebészeti beavatkozások kapcsán a betegek 15–60%-ában alakul ki mélyvénás trombózis vagy tüdőembólia, és az utóbbi ma is vezető kórházi halálok. Bár a vénás thromboemboliát leggyakrabban a közelmúltban végzett műtéttel vagy traumával hozzák kapcsolatba, a szimptómás thromboemboliás események 50–70%-a és a fatális tüdőembóliák 70–80%-a nem a sebészeti betegekben alakul ki. Nemzetközi és hazai felmérések alapján a nagy kockázattal rendelkező sebészeti betegek többsége megkapja a szükséges trombózisprofilaxist. Azonban profilaxis nélkül marad a rizikóval rendelkező belgyógyászati betegek jelentős része, a konszenzuson alapuló nemzetközi és hazai irányelvi ajánlások ellenére. A belgyógyászati betegek körében növelni kell a profilaxisban részesülők arányát és el kell érni, hogy trombózisrizikó esetén a betegek megkapják a hatásos megelőzést. A beteg trombóziskockázatának felmérése fontos eszköze a vénás thromboembolia által veszélyeztetett betegek felderítésének, megkönnyíti a döntést a profilaxis elrendeléséről és javítja az irányelvi ajánlások betartását. A trombózisveszély megállapításakor, ha nem ellenjavallt, profilaxist kell alkalmazni. „A thromboemboliák kockázatának csökkentése és kezelése” című, 4. magyar antithromboticus irányelv felhívja a figyelmet a vénástrombózis-rizikó felmérésének szükségességére, és elsőként tartalmazza a kórházban fekvő belgyógyászati és sebészeti betegek kockázati kérdőívét. Ismertetjük a kockázatbecslő kérdőíveket és áttekintjük a kérdőívekben szereplő rizikófaktorokra vonatkozó bizonyítékokon alapuló adatokat.


Author(s):  
C.K. Lakshminarayan ◽  
S. Pabbisetty ◽  
O. Adams ◽  
F. Pires ◽  
M. Thomas ◽  
...  

Abstract This paper deals with the basic concepts of Signature Analysis and the application of statistical models for its implementation. It develops a scheme for computing sample sizes when the failures are random. It also introduces statistical models that comprehend correlations among failures that fail due to the same failure mechanism. The idea of correlation is important because semiconductor chips are processed in batches. Also any risk assessment model should comprehend correlations over time. The statistical models developed will provide the required sample sizes for the Failure Analysis lab to state "We are A% confident that B% of future parts will fail due to the same signature." The paper provides tables and graphs for the evaluation of such a risk assessment. The implementation of Signature Analysis will achieve the dual objective of improved customer satisfaction and reduced cycle time. This paper will also highlight it's applicability as well as the essential elements that need to be in place for it to be effective. Different examples have been illustrated of how the concept is being used by Failure Analysis Operations (FA) and Customer Quality and Reliability Engineering groups.


2013 ◽  
Vol 19 (3) ◽  
pp. 521-527 ◽  
Author(s):  
Song YANG ◽  
Shuqin WU ◽  
Ningqiu LI ◽  
Cunbin SHI ◽  
Guocheng DENG ◽  
...  

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