scholarly journals Does it make sense to detect Streptococcus pyogenes during tonsillitis in Europe to prevent acute rheumatic fever?

2014 ◽  
Vol 20 (12) ◽  
pp. O981-O982 ◽  
Author(s):  
S. Edouard ◽  
A. Michel-Lepage ◽  
D. Raoult
Keyword(s):  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever

Bacterial Aetiology of Pharyngotonsillitis in Paediatric Age Group in a Tertiary Care Hospital in Kerala

2021 ◽  
Vol 8 (39) ◽  
pp. 3441-3447
Author(s):  
Thushara Ushakumari Bhuvanendran ◽  
Beena V.G.
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever ◽  
Bacterial Pathogens ◽  
Antibiotic Sensitivity ◽  
Acute Glomerulonephritis ◽  
Age Group ◽  
Common Organism

BACKGROUND Pharyngotonsillitis is defined as a spectrum of conditions ranging from inflammation primarily confined to the tonsils to pharyngitis implying generalized inflammation of the whole of pharynx. Children are more prone to get several episodes of pharyngotonsillitis per year during their school years. Pharyngitis caused by Streptococcus pyogenes can cause two non-suppurative complications, acute rheumatic fever and acute glomerulonephritis which is responsible for significant morbidity and mortality. The present study was conducted to identify the prevalence of bacterial pathogens causing pharyngotonsillitis and to study their antibiotic sensitivity pattern that would indicate the optimum line of treatment. METHOD A total of 200 children at the age group of 2 - 12 years who had clinical features of pharyngotonsillitis according to the inclusion criteria were recruited for this study over a period of one year. With the help of a disposable wooden spatula, pus from the pharyngo tonsillar region was collected and processed. Predominant isolates obtained were identified and antibiotic sensitivity was done. RESULTS Bacteria was isolated from 70 samples. Pharyngotonsillitis was found most prevalent at the age group of 8 – 10 years. Intake of cold food stuffs and passive smoking at home was found to have statistically significant association as risk factor for pharyngotonsillitis. Staphylococcus aureus was the most common organism isolated followed by Streptococcus pyogenes. The other organisms isolated were group G and C streptococci, Streptococcus pneumoniae, Pseudomonas aeruginosa and Klebsiella pneumonia sub species (spp) aerogenes. CONCLUSIONS Staphylococcus aureus was the most common organism isolated, followed by Streptococcus pyogenes. All the isolates of beta haemolytic streptococci were found to be sensitive to penicillin. There was increased incidence of resistance to macrolides among the gram-positive isolates except Streptococcus pneumoniae and it may be due to the wide spread use of macrolides injudiciously. All the bacterial pharyngotonsillitis cases were cured with the antibiotic given according to the sensitivity except one case. KEYWORDS Pharyngotonsillitis, Acute Rheumatic Fever, Acute Glomerulonephritis, Bacterial Pathogens, Antibiogram

Utility of Detecting sof Gene as Evidence of Streptococcus pyogenes Infection in Acute Rheumatic Fever

2019 ◽  
Vol 56 (4) ◽  
pp. 311-313
Author(s):  
Nikki Agarwal ◽  
Seema Kapoor ◽  
Ankit Mangla ◽  
Ashok Kumar ◽  
Ravi N. Mandal ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever

scholarly journals Acute Rheumatic Fever: A Disease of the Past?

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Robert L. Myette
Keyword(s):  
Case Report ◽  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever ◽  
Healthy Children ◽  
Marginalized Populations ◽  
Urban Hospital ◽  
Urban Centers ◽  
The Past ◽  
Delays In Diagnosis

Introduction. Acute rheumatic fever (ARF) is a manifestation of the nonsuppurative sequelae of Streptococcus pyogenes infection. Herein, two cases of ARF are presented to highlight that this disease is present in urban cities, can be diagnosed in otherwise healthy children, and that its diagnosis may be challenging, or marred with confounders, leading to delays in diagnosis. Case Report. Two unrelated children, age 7 and 9, presented to an urban hospital in Canada with unique manifestations of ARF. Diagnosis of ARF in the first patient was interrupted by a course of steroids which masked symptoms leading to therapeutic delays. The second patient presented with facial droop and symptoms thought to be viral, thus leading to misdiagnosis as Bell’s palsy. Discussion/Conclusion. ARF is more common in underserviced and marginalized populations, which may lead clinicians in urban centers to overlook signs or symptoms suggestive of ARF because they no longer see this condition routinely, or they believe it is a disease of the past.

scholarly journals Complete Genome of Acute Rheumatic Fever-Associated Serotype M5 Streptococcus pyogenes Strain Manfredo

2006 ◽  
Vol 189 (4) ◽  
pp. 1473-1477 ◽  
Author(s):  
Matthew T. G. Holden ◽  
Annabel Scott ◽  
Inna Cherevach ◽  
Tracey Chillingworth ◽  
Carol Churcher ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Complete Genome ◽  
Acute Rheumatic Fever ◽  
Close Relationship

ABSTRACT Comparisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously sequenced genomes emphasized the role of prophages in diversification of S. pyogenes and the close relationship between strain Manfredo and MGAS8232, another acute rheumatic fever-associated strain.

scholarly journals M-Protein Analysis of Streptococcus pyogenes Isolates Associated with Acute Rheumatic Fever in New Zealand

2015 ◽  
Vol 53 (11) ◽  
pp. 3618-3620 ◽  
Author(s):  
Deborah A. Williamson ◽  
Pierre R. Smeesters ◽  
Andrew C. Steer ◽  
John D. Steemson ◽  
Adrian C. H. Ng ◽  
...  
Keyword(s):  
New Zealand ◽  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever ◽  
Skin Infection ◽  
Protein Analysis ◽  
M Protein ◽  
Content Type ◽  
Typing System ◽  
Group A

We applied anemmcluster typing system to group AStreptococcusstrains in New Zealand, including those associated with acute rheumatic fever (ARF). We observed few so-called rheumatogenicemmtypes but found a high proportion ofemmtypes previously associated with pyoderma, further suggesting a role for skin infection in ARF.

Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever

2015 ◽  
Vol 14 (7) ◽  
pp. 616-621 ◽  
Author(s):  
Susanna Esposito ◽  
Sonia Bianchini ◽  
Michele Fastiggi ◽  
Monica Fumagalli ◽  
Laura Andreozzi ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever

Molecular characterization of Streptococcus pyogenes isolates collected during periods of increased acute rheumatic fever activity in Utah

2004 ◽  
Vol 23 (1) ◽  
pp. 56-61 ◽  
Author(s):  
LONNIE J. MINER ◽  
SUSAN J. PETHERAM ◽  
JUDY A. DALY ◽  
E. KENT KORGENSKI ◽  
KRISTIE S. SELIN ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Molecular Characterization ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever

scholarly journals Structural Conservation, Variability, and Immunogenicity of the T6 Backbone Pilin of Serotype M6 Streptococcus pyogenes

2014 ◽  
Vol 82 (7) ◽  
pp. 2949-2957 ◽  
Author(s):  
Paul G. Young ◽  
Nicole J. Moreland ◽  
Jacelyn M. Loh ◽  
Anita Bell ◽  
Polly Atatoa Carr ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever ◽  
Vaccine Development ◽  
Group A Streptococcus ◽  
T Antigen ◽  
Gram Positive ◽  
Content Type ◽  
Future Design

ABSTRACTGroup A streptococcus (GAS;Streptococcus pyogenes) is a Gram-positive human pathogen that causes a broad range of diseases ranging from acute pharyngitis to the poststreptococcal sequelae of acute rheumatic fever. GAS pili are highly diverse, long protein polymers that extend from the cell surface. They have multiple roles in infection and are promising candidates for vaccine development. This study describes the structure of the T6 backbone pilin (BP; Lancefield T-antigen) from the important M6 serotype. The structure reveals a modular arrangement of three tandem immunoglobulin-like domains, two with internal isopeptide bonds. The T6 pilin lysine, essential for polymerization, is located in a novel VAKS motif that is structurally homologous to the canonical YPKN pilin lysine in other three- and four-domain Gram-positive pilins. The T6 structure also highlights a conserved pilin core whose surface is decorated with highly variable loops and extensions. Comparison to other Gram-positive BPs shows that many of the largest variable extensions are found in conserved locations. Studies with sera from patients diagnosed with GAS-associated acute rheumatic fever showed that each of the three T6 domains, and the largest of the variable extensions (V8), are targeted by IgG during infectionin vivo. Although the GAS BP show large variations in size and sequence, the modular nature of the pilus proteins revealed by the T6 structure may aid the future design of a pilus-based vaccine.

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