Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case–control study

Background: Postponing motherhood is a worldwide trend. As a woman ages, the ability to get pregnant naturally decreases. The postponement of motherhood is related to the increased availability of assisted reproductive technology, which is associated with a higher incidence of maternal health problems. Aim of the study: To compare the health problems encountered during pregnancy, childbirth and early postpartum, and to examine the health status of the newborn, in women over 35 years of age who received in vitro fertilisation (IVF) or conceived naturally. Material and methods: A retrospective comparative case-control study was carried out based on the analysis of medical records from women who gave birth after 35 years of age. The study was conducted in two hospitals of the third level of reference in Warsaw, Poland. A group of women who gave birth after IVF (n=240) was compared with a control group who gave birth following natural fertilisation (n=240). Results: Women after IVF were statistically more likely to be obese (5% vs 0.2%, p=0.001), to have received infertility treatment (18% vs 1%, p=0.000) before pregnancy, and to experience cholestasis during pregnancy (4% vs. 1%, p=0.019). There was a higher incidence of multiple pregnancies [twins (10% vs 1%, p=0.0001) and triplets (0.5%, p=0.0001)], and deliveries by caesarean section (61% vs 51%, p=0.027) in women from the IVF group. The groups did not differ with respect to preterm delivery, duration of pregnancy, or 1st, 2nd and 3rd periods of labour. Mothers in the IVF group had a statistically longer perinatal hospital stay (7±8 vs 5±4 days, p=0.001). Conclusions: Women over 35 years of age after IVF have a higher rate of caesarean sections and multiple pregnancies. Obesity before pregnancy and cholestasis during pregnancy are also more common in this group. There is no difference between the health status of newborns from mothers after in vitro or natural fertilisation.

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Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study

The Lancet ◽

10.1016/s0140-6736(00)05180-1 ◽

2001 ◽

Vol 357 (9274) ◽

pp. 2080-2084 ◽

Cited By ~ 142

Author(s):

AG Sutcliffe ◽

B Taylor ◽

K Saunders ◽

S Thornton ◽

BA Leiberman ◽

...

Keyword(s):

Intracytoplasmic Sperm Injection ◽

Case Control Study ◽

Case Control ◽

In Vitro Fertilisation ◽

Second Year Of Life ◽

Second Year ◽

Control Study

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The Identification and Significance of a Thr→Pro Polymorphism in Kringle IV Type 8 of Apolipoprotein(a)

Thrombosis and Haemostasis ◽

10.1055/s-0038-1656083 ◽

1997 ◽

Vol 77 (05) ◽

pp. 0949-0954 ◽

Cited By ~ 8

Author(s):

J Prins ◽

F R Lues ◽

Y Y van der Hoek ◽

J J.P Kastelein ◽

B N Bouma ◽

...

Keyword(s):

Case Control Study ◽

Amino Acid Position ◽

Case Control ◽

Binding Studies ◽

Binding Characteristics ◽

Apolipoprotein A ◽

Significant Independent Risk Factor ◽

And Gender ◽

Control Study

SummaryElevated plasma levels of lipoprotein(a) [Lp(a)] represent a significant independent risk factor for the development of atherosclerosis. Interindividual levels of apo(a) vary over 1000-fold and are mainly due to inheritance that is linked to the locus of the apolipoprotein(a) [apo(a)] gene. The apo(a) gene encodes multiple repeats of a sequence exhibiting up to 85% DNA sequence homology with plasminogen kringle IV (K.IV), a lysine binding domain. In our search for sequence polymorphisms in the K.IV coding domain, we identified a polymorphism predicting a Thr→Pro substitution located at amino acid position 12 of kringle IV type 8 of apo(a). The functional and clinical significance of this polymorphism was analysed in a case-control study and by comparing the in vitro lysine binding characteristics of the two Lp(a) subtypes.The case-control study (involving 153 subjects having symptomatic atherosclerosis and 153 age and gender matched normolipidemic controls) revealed an overall allele frequency for the Thr12-→Pro substitution in kringle IV type 8 of 14% and a negative association between presence of the Pro12-subtype and symptomatic atherosclerosis (p <0.03). The in vitro lysine binding studies, using Lp(a) isolated from subjects homozygous for either Thr12 or Pro12 in K.IV type 8, revealed comparable lysine-Sepharose binding fractions for the two subtypes. The binding affinity (Kd) for immobilised plasmin degraded des- AA-fibrin (DesafibTM-X) was also comparable for the two subtypes, however a decreased maximal attainable binding (Bmax) for immobilised desafibTM-X was observed for the Pro12-subtype Lp(a).

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Results from a case-control study comparing mean aneuploidy rates and pregnancy outcomes in women with and without endometriosis undergoing In Vitro Fertilization (IVF) cycles

10.26226/morressier.5af300af738ab10027aa9559 ◽

2018 ◽

Author(s):

Roberta Venturella ◽

Danilo Cimadomo ◽

Laura Francesca Rienzi

Keyword(s):

In Vitro Fertilization ◽

Pregnancy Outcomes ◽

Case Control Study ◽

Case Control ◽

Vitro Fertilization ◽

Control Study

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The relationship between urinary phthalate metabolites and polycystic ovary syndrome in women undergoing in vitro fertilization: Nested case-control study

Chemosphere ◽

10.1016/j.chemosphere.2021.131495 ◽

2021 ◽

pp. 131495

Author(s):

Iman Al-Saleh

Keyword(s):

In Vitro Fertilization ◽

Case Control Study ◽

Polycystic Ovary ◽

Case Control ◽

Ovary Syndrome ◽

Vitro Fertilization ◽

Nested Case Control ◽

The Relationship ◽

Control Study

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Examine the Frequency of Postnatal Depression in Mothers having Malnourished Infants

10.53350/pjmhs2115123170 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3170-3171

Author(s):

Muhammad Ilyas ◽

Jawed Akbar Dars ◽

Chooni Lal ◽

Fazal Ullah

Keyword(s):

Postnatal Depression ◽

Case Control Study ◽

Case Control ◽

Healthy Weight ◽

Malnourished Children ◽

Healthy Mother ◽

Post Natal Depression ◽

Inducing Factors ◽

Healthy Growth ◽

Control Study

Background: Healthy child development is dependent on a mentally and physically healthy mother. Depressions in mother can adversely affect their offspring healthy growth. Aim: To estimate the frequency of post-natal depression in mothers having malnourished infants. Place and duration of study: Department of Psychiatry, Balochistan Institute of Psychiatry & Behavioral Sciences, Qeutta from 1st January 2020 to 31st December 2020. Methodology: In this case control study 250 mothers (125 were malnourished infants or toddlers mothers and other 125 from healthy weight infants/toddlers mothers) were interviewed to assess their depressional state. Their stress inducing factors, age and other clinical comorbidities were also documented. Results: Mean mother age of malnourished infants/toddlers was 28.1±6.6 years in comparison to 27.8±5.2 years of healthy weight infants/toddlers mother’s respectively. Twenty four percent malnourished infant/toddlers’ mothers were single parent. Un-employed spouse of mothers to malnourished infant/toddlers were found at higher frequency (51.06%) than of healthy infant/toddlers (23.4%).The frequency of post-natal depression among mothers of malnourished infants/toddlers was observed in 57.6% cases Conclusion: Out of total 57.5% mothers of malnourished children suffering from post-natal depression there are 15.2% to 9.6% those having moderate to highly moderate post-natal depression. Keywords: Post-natal depression, Malnourish, Infants, Toddlers

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Comparing four laboratory three-parent techniques to construct human aged non-surrounded nucleolus germinal vesicle oocytes: A case-control study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i6.7284 ◽

2020 ◽

Author(s):

Sara Darbandi ◽

Mahsa Darbandi ◽

Ashok Agarwal ◽

Hamid Reza Khorram khorshid ◽

Mohammad Reza Sadeghi ◽

...

Keyword(s):

Case Control Study ◽

Germinal Vesicle ◽

Oocyte Donation ◽

Case Control ◽

Assisted Reproductive Technique ◽

Oocyte Competence ◽

Reproductive Techniques ◽

Developmental Capacity ◽

Control Study

Background: The three-parent assisted reproductive technique may increase oocyte competence. Objective: In this case-control study, the suitability of germinal vesicle transfer (GVT), synchronous ooplasmic transfer (sOT), asynchronous ooplasmic transfer using cryopreserved MII oocyte (caOT), and asynchronous ooplasmic transfer using waste MII oocyte (waOT) for maturation of the human-aged non-surrounded nucleolus germinal vesicle-stage (NSN-GV) oocyte were investigated. Materials and Methods: NSN-GV oocytes were subjected to four methods: group A (GVT), B (sOT), C (caOT) D (waOT), and E (Control). The fusion rates, MI, MII, ICSI observations and cleavage at 2-cell, 4-cell, and 8-cell stages were compared in the groups. Results: In GVT, none of the oocytes fused. In sOT, all oocytes fused, 20 achieved the MI, 14 progressed to MII, 8 fertilized, 6 cleaved and 5, 4, and 3 achieved the 2- cells, 4-cells and 8-cells, respectively. In caOT, all oocytes fused and achieved the MI, 8 progressed to MII and fertilized, 6 cleaved and 6, 5, and 5 achieved the 2-cells, 4- cells, and 8-cells respectively. In waOT, all oocytes fused, 5 and 3 progressed to MI and MII, respectively, but only one fertilized, cleaved and reached a 4-cells stage. In group E, 6 and 2 oocytes progressed to MI and MII, respectively, and only one fertilized but arrested at the zygote stage. caOT had the highest survival rate when compared to sOT (p = 0.04), waOT (p = 0.002), and control (p = 0.001). Conclusion: The caOT method was beneficial over sOT, waOT, and GVT in supplementing the developmental capacity of human-aged NSN-GV oocytes. Key words: Assisted reproductive techniques, In vitro oocyte maturation techniques, Nuclear transfer techniques, Oocytes, Oocyte donation.

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