Maternal and fetal outcomes in women with cerebrovascular malformations in pregnancy: a multicentre retrospective cohort study

Abstract Background: Blood urea nitrogen (BUN) and creatinine (SCr) are associated with gestational diabetes mellitus (GDM). However, there were limited data in the literature on the influence of BUN and SCr on maternal and fetal outcomes of pregnancy. We aimed to examine the association of BUN and SCr levels during gestation with the risk of selected adverse pregnancy outcomes.Methods: This retrospective cohort study included 1606 singleton mothers aged 22-44 years. Both BUN and SCr levels were collected and measured during the second (16-18th week), third (28-30th week) trimesters of gestation respectively and followed up pregnancy outcomes. Statistical analysis was used multivariate logistic regression. Results: In the multivariate adjusted logistic regression model, the highest level of SCr in the second trimester increased the risk of PROM by 45% (95% CI, 1.01-2.09). In the third trimester of gestation, compared with those in the lowest quartile, BUN levels in the highest quartile decreased the risk of macrosomia and LGA by 60%(95% CI, 0.20-0.78), 66%(95% CI, 0.21,0.55) , respectively, and increased the risk of SGA by 137%(1.06, 5.31), 186%(1.29,6.34) in the third and fourth quartiles, respectively. The adjusted OR (95%CI) for macrosomia in the fourth quartile was 0.46 (0.24, 0.87), for SGA in the third quartiles was 2.36 (1.10, 5.10), and for LGA in the fourth quartile was 0.61 (0.41,0.91) compared with those in the first quartile of SCr levels. The elevated changes of BUN (> 0.64mmol/L) was the risk factor of SGA (OR: 2.11, 95%CI: 1.03,4.32).Conclusion: Higher BUN and SCr levels during the 28-30th week of gestation even those towards the upper limit of the normal range can act as a warning sign of the impending SGA. Elevated changes of BUN and SCr during pregnancy also associated with the lower birth weight.

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379: Outcomes from chronic hypertension in pregnancy by gestational age: a retrospective cohort study

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2013.10.412 ◽

2014 ◽

Vol 210 (1) ◽

pp. S192

Author(s):

Teresa Worstell ◽

Margaret Gorman ◽

Aaron Caughey

Keyword(s):

Cohort Study ◽

Gestational Age ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Chronic Hypertension ◽

Hypertension In Pregnancy ◽

In Pregnancy

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Pertussis Immunisation in Pregnancy Safety (PIPS) Study: A retrospective cohort study of safety outcomes in pregnant women vaccinated with Tdap vaccine

Vaccine ◽

10.1016/j.vaccine.2018.07.011 ◽

2018 ◽

Vol 36 (34) ◽

pp. 5173-5179 ◽

Cited By ~ 21

Author(s):

Jennifer B. Griffin ◽

Lennex Yu ◽

Donna Watson ◽

Nikki Turner ◽

Tony Walls ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Safety Outcomes ◽

Tdap Vaccine ◽

In Pregnancy

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Outcomes of visceral leishmaniasis in pregnancy: A retrospective cohort study from South Sudan

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0007992 ◽

2020 ◽

Vol 14 (1) ◽

pp. e0007992 ◽

Cited By ~ 1

Author(s):

Judith E. Pekelharing ◽

Francis Gatluak ◽

Tim Harrison ◽

Fernando Maldonado ◽

M. Ruby Siddiqui ◽

...

Keyword(s):

Cohort Study ◽

Visceral Leishmaniasis ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

South Sudan ◽

In Pregnancy

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Association between birth weight and massive haemorrhage in pregnancy with a low-lying placenta: a 9-year single-centre retrospective cohort study in Japan

Journal of Obstetrics and Gynaecology ◽

10.1080/01443615.2018.1454413 ◽

2018 ◽

Vol 39 (1) ◽

pp. 22-26 ◽

Cited By ~ 1

Author(s):

Satoshi Shinohara ◽

Yasuhiko Okuda ◽

Shuji Hirata

Keyword(s):

Cohort Study ◽

Birth Weight ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Single Centre ◽

Massive Haemorrhage ◽

In Pregnancy

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Hyperglycaemia in Pregnancy and Anthropometric Parameters in the Offspring at 10 Years: A Community-Based Retrospective Cohort Study in Sri Lanka

Journal of Obesity ◽

10.1155/2020/2735148 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Himali P. Herath ◽

Rasika P. Herath ◽

Rajitha Wickremasinghe

Keyword(s):

Cohort Study ◽

Waist Circumference ◽

Sri Lanka ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Skinfold Thickness ◽

Anthropometric Parameters ◽

Community Based ◽

Triceps Skinfold Thickness ◽

In Pregnancy

Background. Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimates for childhood obesity that are attributable to maternal diabetes in utero. Objective. The aim of this study was to determine the association between hyperglycaemia in pregnancy (HIP) and anthropometric parameters in the offspring at 10-11 years of age. Methods. A community-based retrospective cohort study was conducted in Colombo district, Sri Lanka. In the first stage, children born in 2005 were identified, and the availability of antenatal records was assessed. In the second stage, the exposure status of participants was ascertained based on antenatal records and predefined criteria. In the third stage, height, weight, waist circumference, and triceps skinfold thickness (TSFT) of eligible participants were measured to ascertain the outcome status. Background characteristics were collected by interviewing mothers. A 24-hour dietary recall and a 3-day diet diary were recorded. Results. 159 children of mothers with HIP (exposed) and 253 children of mothers with no HIP (nonexposed) participated. Mean ages (SD) of exposed and unexposed groups were 10.9 (0.3) and 10.8 (0.3) years, respectively. The median BMI (17.6 vs 16.1, p<0.001), waist circumference (63 cm vs 59.3 cm, p<0.001), and triceps skinfold thickness (13.7 mm vs 11.2 mm, p<0.001) were significantly higher in the exposed group. Offspring of women with HIP were more likely to be overweight (aOR = 2.6, 95% CI 1.4–4.9) and have abdominal obesity (aOR = 2.7, 95% CI 1.1–6.5) and high TSFT (aOR = 2.2, 95% CI 1.06–4.7) at 10-11 years than children who were not exposed after adjusting for maternal BMI, maternal age at delivery, and birth order. Conclusions. Intrauterine exposure to HIP is a significant determinant of overweight, high TSFT, and abdominal obesity in the offspring.

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