scholarly journals Corrigendum: Age‐dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans

Aging Cell ◽  
2020 ◽  
Vol 19 (11) ◽  
Keyword(s):  
Caenorhabditis Elegans ◽  
Response Property ◽  
Age Dependent

scholarly journals Age‐dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans

Aging Cell ◽  
2020 ◽  
Vol 19 (5) ◽  
Author(s):  
Tzu‐Ting Huang ◽  
Hironori J. Matsuyama ◽  
Yuki Tsukada ◽  
Aakanksha Singhvi ◽  
Ru‐Ting Syu ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Response Property ◽  
Age Dependent

scholarly journals TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans

PLoS Genetics ◽  
2012 ◽  
Vol 8 (7) ◽  
pp. e1002806 ◽  
Author(s):  
Alexandra Vaccaro ◽  
Arnaud Tauffenberger ◽  
Peter E. A. Ash ◽  
Yari Carlomagno ◽  
Leonard Petrucelli ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Stress Signaling ◽  
Age Dependent

Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans

2018 ◽  
Vol 45 (12) ◽  
pp. 651-662 ◽  
Author(s):  
Emmanuel Enoch Dzakah ◽  
Ahmed Waqas ◽  
Shuai Wei ◽  
Bin Yu ◽  
Xiaolin Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Target Gene ◽  
Dependent Manner ◽  
Target Gene Expression ◽  
Age Dependent

scholarly journals DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans

2020 ◽  
Vol 10 (5) ◽  
pp. 1521-1539 ◽  
Author(s):  
Daniel R. McHugh ◽  
Elena Koumis ◽  
Paul Jacob ◽  
Jennifer Goldfarb ◽  
Michelle Schlaubitz-Garcia ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Caenorhabditis Elegans ◽  
Host Defense ◽  
Insulin Signaling ◽  
Bacterial Pathogens ◽  
C Elegans ◽  
Link Type ◽  
Age Dependent ◽  
Over Time

Aging is accompanied by a progressive decline in immune function termed “immunosenescence”. Deficient surveillance coupled with the impaired function of immune cells compromises host defense in older animals. The dynamic activity of regulatory modules that control immunity appears to underlie age-dependent modifications to the immune system. In the roundworm Caenorhabditis elegans levels of PMK-1 p38 MAP kinase diminish over time, reducing the expression of immune effectors that clear bacterial pathogens. Along with the PMK-1 pathway, innate immunity in C. elegans is regulated by the insulin signaling pathway. Here we asked whether DAF-16, a Forkhead box (FOXO) transcription factor whose activity is inhibited by insulin signaling, plays a role in host defense later in life. While in younger C. elegansDAF-16 is inactive unless stimulated by environmental insults, we found that even in the absence of acute stress the transcriptional activity of DAF-16 increases in an age-dependent manner. Beginning in the reproductive phase of adulthood, DAF-16 upregulates a subset of its transcriptional targets, including genes required to kill ingested microbes. Accordingly, DAF-16 has little to no role in larval immunity, but functions specifically during adulthood to confer resistance to bacterial pathogens. We found that DAF-16-mediated immunity in adults requires SMK-1, a regulatory subunit of the PP4 protein phosphatase complex. Our data suggest that as the function of one branch of the innate immune system of C. elegans (PMK-1) declines over time, DAF-16-mediated immunity ramps up to become the predominant means of protecting adults from infection, thus reconfiguring immunity later in life.

Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans

2012 ◽  
Vol 47 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Kopal Saharia ◽  
Upasna Arya ◽  
Ranjeet Kumar ◽  
Rashmi Sahu ◽  
Chinmaya Kumar Das ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Neurotransmitter Release ◽  
Age Dependent

scholarly journals Age-dependent changes of nuclear morphology are uncoupled from longevity in Caenorhabditis elegans IGF/insulin receptor daf-2 mutants

2014 ◽  
Vol 15 (3) ◽  
pp. 279-288 ◽  
Author(s):  
Mercedes M. Pérez-Jiménez ◽  
María Jesús Rodríguez-Palero ◽  
Eduardo Ródenas ◽  
Peter Askjaer ◽  
Manuel J. Muñoz
Keyword(s):  
Caenorhabditis Elegans ◽  
Insulin Receptor ◽  
Nuclear Morphology ◽  
Age Dependent

scholarly journals DAF-18 is required for the age-dependent increase in DAF-16 activity in Caenorhabditis elegans

2020 ◽  
Author(s):  
Kali Carrasco ◽  
Matthew J. Youngman
Keyword(s):  
Caenorhabditis Elegans ◽  
Functional Characterization ◽  
Growth Factor Signaling ◽  
Dynamic Activity ◽  
Post Translational Modifications ◽  
C Elegans ◽  
Regulatory Module ◽  
Phospholipid Signaling ◽  
Age Dependent ◽  
Foxo Transcription Factors

ABSTRACTThe insulin/insulin-like growth factor signaling (IIS) pathway modulates growth, survival, and lifespan by regulating FOXO transcription factors. In Caenorhabditis elegans, IIS maintains DAF-16/FOXO in an inactive state unless animals are challenged by environmental stress. Recent evidence suggests that DAF-16 becomes activated as part of normal aging in C. elegans, yet the regulatory module responsible for this phenomenon is largely undefined. Embedded within IIS is phospholipid signaling in which PIP3 produced by the PI3 kinase AGE-1 is an upstream event in DAF-16 inhibition. Countering AGE-1 is DAF-18, an ortholog of human PTEN phosphatase that dephosphorylates PIP3. Although it is required for normal lifespan in C. elegans, functional characterization of DAF-18 has primarily focused on its roles during development in the germline and neurons. In this study we asked whether DAF-18 plays a role in the age-dependent activation of DAF-16, and specifically in DAF-16-mediated immunity. Our data show that DAF-18 is expressed in multiple tissues during adulthood. We found that DAF-18 contributes to host defense in adult animals by functioning in the neurons and intestine, likely working through DAF-16 which acts in those same tissues to confer immunity. Supporting this possibility, DAF-18 was required for increased DAF-16 transcriptional activity during aging. Post-translational modifications including ubiquitination and sumoylation appear to be required for the function of DAF-18 during aging in C. elegans, indicating that strategies to modulate PTEN activity are evolutionarily conserved. Our results establish an important role for DAF-18 later in life and imply that it is a critical component of a neuroendocrine signaling circuit that governs the dynamic activity of DAF-16.

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