Working memory and salivary brain-derived neurotrophic factor as developmental predictors of cocaine seeking in male and female rats

2017 ◽  
Vol 23 (3) ◽  
pp. 868-879 ◽  
Author(s):  
Chloe J. Jordan ◽  
Susan L. Andersen
Keyword(s):  
Working Memory ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking

scholarly journals Attenuated cocaine-seeking after oxytocin administration in male and female rats

2018 ◽  
Vol 235 (7) ◽  
pp. 2051-2063 ◽  
Author(s):  
Amy S. Kohtz ◽  
Belle Lin ◽  
Michael E. Smith ◽  
Gary Aston-Jones
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking

scholarly journals Metformin in nucleus accumbens core reduces cue-induced cocaine seeking in male and female rats

2021 ◽  
Author(s):  
Amy Chan ◽  
Alexis Willard ◽  
Sarah Mulloy ◽  
Noor Ibrahim ◽  
Allegra Sciaccotta ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Female Rats ◽  
Therapeutic Effects ◽  
Self Administration ◽  
Nucleus Accumbens Core ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking ◽  
Ampk Activity ◽  
Accumbens Core

This study investigated the potential therapeutic effects of the FDA-approved drug metformin on cue-induced reinstatement of cocaine seeking. Metformin (dimethyl-biguanide) is a first-line treatment for type II diabetes that, among other mechanisms, is involved in the activation of adenosine monophosphate activated protein kinase (AMPK). Cocaine self-administration and extinction is associated with decreased levels of phosphorylated AMPK within the nucleus accumbens core (NAcore). Previously it was shown that increasing AMPK activity in the NAcore decreased cue-induced reinstatement of cocaine seeking. Decreasing AMPK activity produced the opposite effect. The goal of the present study was to determine if metformin in the NAcore reduces cue-induced cocaine seeking in adult male and female Sprague Dawley rats. Rats were trained to self-administer cocaine followed by extinction prior to cue-induced reinstatement trials. Metformin microinjected in the NAcore attenuated cue-induced reinstatement in male and female rats. Importantly, metformin's effects on cocaine seeking were not due to a general depression of spontaneous locomotor activity. In female rats, metformin's effects did generalize to a reduction in cue-induced reinstatement of sucrose seeking. These data support a potential role for metformin as a pharmacotherapy for cocaine use disorder, but warrant caution given the potential for metformin's effects to generalize to a natural reward in female rats.

Differential Expression of Bladder Neurotrophic Factor mRNA in Male and Female Rats After Bladder Outflow Obstruction

2002 ◽  
pp. 2682-2688 ◽  
Author(s):  
PETER ZVARA ◽  
JAN KLIMENT ◽  
ANTHONY L. DeROSS ◽  
BRIAN H. IRWIN ◽  
SUSAN E. MALLEY ◽  
...  
Keyword(s):  
Differential Expression ◽  
Neurotrophic Factor ◽  
Female Rats ◽  
Outflow Obstruction ◽  
Male And Female ◽  
Bladder Outflow Obstruction ◽  
Male And Female Rats

Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats

2008 ◽  
Vol 203 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Justin J. Anker ◽  
Nathan A. Holtz ◽  
Natalie Zlebnik ◽  
Marilyn E. Carroll
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking ◽  
Seeking Behavior

scholarly journals Ceftriaxone and mGlu2/3 interactions in the nucleus accumbens core affect the reinstatement of cocaine-seeking in male and female rats

2020 ◽  
Vol 237 (7) ◽  
pp. 2007-2018 ◽  
Author(s):  
Carly N. Logan ◽  
Allison R. Bechard ◽  
Peter U. Hamor ◽  
Lizhen Wu ◽  
Marek Schwendt ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Female Rats ◽  
Nucleus Accumbens Core ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking ◽  
Core Affect ◽  
Accumbens Core

The effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male and female rats neonatally treated with quinpirole

2006 ◽  
Vol 24 (7) ◽  
pp. 2075-2083 ◽  
Author(s):  
Stephanie K. Thacker ◽  
Marla K. Perna ◽  
Jeffery J. Ward ◽  
Tori L. Schaefer ◽  
Michael T. Williams ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Neurotrophic Factor ◽  
Female Rats ◽  
Male And Female ◽  
Factor Content ◽  
Olanzapine Treatment ◽  
Male And Female Rats
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