Developmental changes in the hypothalamic mRNA expression levels of brain‐derived neurotrophic factor and serum leptin levels: Their responses to fasting in male and female rats

2016 ◽  
Vol 54 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Kiyohito Yano ◽  
Munkhsaikhan Munkhzaya ◽  
Altankhuu Tungalagsuvd ◽  
...  
2015 ◽  
Vol 41 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Toshiya Matsuzaki ◽  
Takeshi Iwasa ◽  
Munkhsaikhan Munkhzaya ◽  
Altankhuu Tungalagsuvd ◽  
Takako Kawami ◽  
...  

2017 ◽  
Vol 64 (12) ◽  
pp. 1157-1163 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Yiliyasi Mayila ◽  
Kiyohito Yano ◽  
Minoru Irahara

2016 ◽  
Vol 94 (4) ◽  
pp. 408-415 ◽  
Author(s):  
Xiaoyuan Han ◽  
Sonali Shaligram ◽  
Rui Zhang ◽  
Leigh Anderson ◽  
Roshanak Rahimian

Hyperglycemia affects male and female vascular beds differently. We have previously shown that 1 week after the induction of diabetes with streptozotocin (STZ), male and female rats exhibit differences in aortic endothelial function. To examine this phenomenon further, aortic responses were studied in male and female rats 8 weeks after the induction of diabetes (intermediate stage). Endothelium-dependent vasodilation (EDV) to acetylcholine (ACh) was measured in phenylephrine (PE) pre-contracted rat aortic rings. Concentration response curves to PE were generated before and after L-NAME, a nitric oxide synthase (NOS) inhibitor. Furthermore, mRNA expression of endothelial nitric oxide synthase (eNOS) and NADPH oxidase subunit (Nox1) were determined. At 8 weeks, diabetes impaired EDV to a greater extent in female than male aortae. Furthermore, the responsiveness to PE was significantly enhanced only in female diabetic rats, and basal NO, as indicated by the potentiation of the response to PE after L-NAME, was reduced in female diabetic rat aortae to the same levels as in males. In addition, eNOS mRNA expression was decreased, while the Nox1 expression was significantly enhanced in diabetic female rats. These results suggest that aortic function in female diabetic rats after 8 weeks exhibits a more prominent impairment and that NO may be involved.


1985 ◽  
Vol 5 (4) ◽  
pp. 309-314 ◽  
Author(s):  
Calvin D. Tormanen ◽  
Barbara E. Sutter

The developmental changes in the activity of kidney transamidinase in male and female rats were investigated. The activity in both sexes increased rapidly after birth, reaching adult levels at 4 days of age. After weaning, the activity in male rats remained constant, while in female rats it declined to 60% ol that in males. Thus, transamidinase is in the neonatal cluster of enzyme differentiation.


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