Acute effects of a very low nicotine content cigarette on laboratory smoking lapse: Impacts of nicotine metabolism and nicotine dependence

2020 ◽  
Author(s):  
Hera E. Schlagintweit ◽  
Rachel F. Tyndale ◽  
Christian S. Hendershot
Keyword(s):  
Nicotine Dependence ◽  
Acute Effects ◽  
Nicotine Metabolism ◽  
Nicotine Content ◽  
Smoking Lapse

scholarly journals Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes

2015 ◽  
Vol 17 (9) ◽  
pp. 1167-1172 ◽  
Author(s):  
Frank C. Bandiera ◽  
Kathryn C. Ross ◽  
Seyedehtaraneh Taghavi ◽  
Kevin Delucchi ◽  
Rachel F. Tyndale ◽  
...  
Keyword(s):  
Nicotine Dependence ◽  
Nicotine Metabolism ◽  
Nicotine Content

scholarly journals Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

2020 ◽  
Vol 22 (1) ◽  
pp. 164
Author(s):  
Khosbayar Lkhagvadorj ◽  
Zhijun Zeng ◽  
Karolin F. Meyer ◽  
Laura P. Verweij ◽  
Wierd Kooistra ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mrna Expression ◽  
Nicotine Dependence ◽  
Susceptibility Gene ◽  
Smoke Exposure ◽  
Adverse Outcomes ◽  
Male Offspring ◽  
Adult Offspring ◽  
Mrna Levels ◽  
Nicotine Metabolism

Prenatal smoke exposure (PreSE) is a risk factor for nicotine dependence, which is further enhanced by postnatal smoke exposure (PostSE). One susceptibility gene to nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine in the liver. Higher CYP2A6 activity is associated with nicotine dependence and could be regulated through DNA methylation. In this study we investigated whether PostSE further impaired PreSE-induced effects on nicotine metabolism, along with Cyp2a5, orthologue of CYP2A6, mRNA expression and DNA methylation. Using a mouse model where prenatally smoke-exposed adult offspring were exposed to cigarette smoke for 3 months, enzyme activity, mRNA levels, and promoter methylation of hepatic Cyp2a5 were evaluated. We found that in male offspring, PostSE increased PreSE-induced cotinine levels and Cyp2a5 mRNA expression. In addition, both PostSE and PreSE changed Cyp2a5 DNA methylation in male groups. PreSE however decreased cotinine levels whereas it had no effect on Cyp2a5 mRNA expression or methylation. These adverse outcomes of PreSE and PostSE were most prominent in males. When considered in the context of the human health aspects, the combined effect of prenatal and adolescent smoke exposure could lead to an accelerated risk for nicotine dependence later in life.

scholarly journals Evidence of Nicotine Dependence in Adolescents Who Use Juul and Similar Pod Devices

2019 ◽  
Vol 16 (12) ◽  
pp. 2135 ◽  
Author(s):  
Rachel Boykan ◽  
Maciej L. Goniewicz ◽  
Catherine R. Messina
Keyword(s):  
Nicotine Dependence ◽  
Early Onset ◽  
Nicotine Addiction ◽  
Urinary Cotinine ◽  
Nicotine Content ◽  
The Past ◽  
Survey Responses

Background: The use of high-nicotine content e-cigarettes (so-called pods, such as Juul) among adolescents raises concerns about early onset of nicotine addiction. Methods: In this analysis of adolescents surveyed from April 2017–April 2018, we compare survey responses and urinary cotinine of pod vs. non-pod using past-week e-cigarette users aged 12–21. Results: More pod users categorized themselves as daily users compared to non-pod users (63.0% vs. 11.0%; p = 0.001); more pod than non-pod users had used e-cigarettes within the past day (76.2% vs. 29.6%; p = 0.001). More pod users responded affirmatively to nicotine dependence questions (21.4% vs. 7.1%; p = 0.04). Urinary cotinine levels were compared among those responding positively and negatively to dependence questions: those with positive responses had significantly higher urinary cotinine levels than those responding negatively. Conclusions: Adolescents who used pod products showed more signs of nicotine dependence than non-pod users. Pediatricians should be vigilant in identifying dependence symptoms in their patients who use e-cigarettes, particularly in those using pod devices.

scholarly journals Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task

2014 ◽  
Vol 231 (24) ◽  
pp. 4649-4657 ◽  
Author(s):  
Christopher W. Kahler ◽  
Jane Metrik ◽  
Nichea S. Spillane ◽  
Anne Day ◽  
Adam M. Leventhal ◽  
...  
Keyword(s):  
High Dose ◽  
Acute Effects ◽  
Smoking Lapse ◽  
Laboratory Analogue ◽  
Lapse Behavior

Acute effects of nicotine content in cigarettes on coronary flow velocity and coronary flow reserve in men

1998 ◽  
Vol 82 (10) ◽  
pp. 1275-1278 ◽  
Author(s):  
Takahiro Tanaka ◽  
Yukiko Oka ◽  
Ineko Tawara ◽  
Toshikatu Sada ◽  
Yuji Kira
Keyword(s):  
Flow Velocity ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Acute Effects ◽  
Coronary Flow Velocity ◽  
Nicotine Content ◽  
Flow Reserve

scholarly journals Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population

BMC Genetics ◽  
2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Masanori Ohmoto ◽  
Tatsuo Takahashi ◽  
Yoko Kubota ◽  
Shinjiro Kobayashi ◽  
Yasuhide Mitsumoto
Keyword(s):  
Smoking Cessation ◽  
Dopamine Receptor ◽  
Dopamine Transporter ◽  
Nicotine Dependence ◽  
Japanese Population ◽  
Genetic Influence ◽  
Nicotine Metabolism

scholarly journals Adolescent smokers’ response to reducing the nicotine content of cigarettes: Acute effects on withdrawal symptoms and subjective evaluations

2018 ◽  
Vol 188 ◽  
pp. 153-160 ◽  
Author(s):  
Rachel N. Cassidy ◽  
Suzanne M. Colby ◽  
Jennifer W. Tidey ◽  
Kristina M. Jackson ◽  
Patricia A. Cioe ◽  
...  
Keyword(s):  
Withdrawal Symptoms ◽  
Acute Effects ◽  
Nicotine Content ◽  
Adolescent Smokers ◽  
Subjective Evaluations

The genetic aspects of nicotine metabolism and their impact on adolescent nicotine dependence

2016 ◽  
Vol 01 (02) ◽  
pp. 105-123 ◽  
Author(s):  
Nael Koudsi ◽  
Jennifer O'Loughlin ◽  
Daniel Rodriguez ◽  
Janet Audrain-McGovern ◽  
Rachel Tyndale
Keyword(s):  
Nicotine Dependence ◽  
Nicotine Metabolism

scholarly journals The Influence of Puff Characteristics, Nicotine Dependence, and Rate of Nicotine Metabolism on Daily Nicotine Exposure in African American Smokers

2016 ◽  
Vol 25 (6) ◽  
pp. 936-943 ◽  
Author(s):  
Kathryn C. Ross ◽  
Delia A. Dempsey ◽  
Gideon St. Helen ◽  
Kevin Delucchi ◽  
Neal L. Benowitz
Keyword(s):  
African American ◽  
Nicotine Dependence ◽  
Nicotine Exposure ◽  
Nicotine Metabolism

Progression from a smoking lapse to relapse: Prediction from abstinence violation effects, nicotine dependence, and lapse characteristics.

1996 ◽  
Vol 64 (5) ◽  
pp. 993-1002 ◽  
Author(s):  
Saul Shiffman ◽  
Mary Hickcox ◽  
Jean A. Paty ◽  
Maryann Gnys ◽  
Jon D. Kassel ◽  
...  
Keyword(s):  
Nicotine Dependence ◽  
Relapse Prediction ◽  
Smoking Lapse
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