Derived muscle arrangements and their shared innervation patterns of external and internal cheek pouches in rodents

2019 ◽  
Vol 49 (1) ◽  
pp. 38-50
Author(s):  
Tomokazu Kawashima ◽  
Richard W. Thorington ◽  
Paula W. Bohaska ◽  
Fumi Sato
Keyword(s):  
Innervation Patterns ◽  
Cheek Pouches

Evolution of Mammalian Cheek Pouches and a Possibly Discontinuous Origin of a Higher Taxon (Geomyoidea)

1976 ◽  
Vol 110 (976) ◽  
pp. 1093-1097 ◽  
Author(s):  
Charles A. Long
Keyword(s):  
Cheek Pouches

Heterotopic transplantation of presumptive placodal ectoderm changes the fate of sensory neuron precursors

Development ◽  
1993 ◽  
Vol 119 (1) ◽  
pp. 263-276 ◽  
Author(s):  
K.S. Vogel ◽  
A.M. Davies
Keyword(s):  
Growth Rate ◽  
Sensory Neurons ◽  
Chicken Embryo ◽  
Neurite Growth ◽  
Heterotopic Transplantation ◽  
Growth And Survival ◽  
Avian Embryos ◽  
Nodose Ganglia ◽  
Innervation Patterns

The placode-derived cranial sensory neurons of the vestibular and nodose ganglia in avian embryos exhibit differences in neurite growth rate and the duration of neurotrophin-independent survival in vitro that arise prior to gangliogenesis and target contact (Davies, A. M. (1989) Nature 337, 553–555; Vogel, K. S. and Davies, A. M. (1991) Neuron 7, 819–830). To ascertain the state of commitment of presumptive placodal ectoderm to differentiate into neurons of the vestibular or nodose type, we performed heterotopic transplantation of labelled presumptive placodal ectoderm at E1.5 in the chicken embryo. We then assayed transplant-derived neurons for hindbrain innervation patterns, neurite growth and survival at E3.5. We show that presumptive placodal ectoderm is not determined to give rise to neurons of the vestibular or nodose phenotype at E1.5. Explantation of presumptive placodal ectoderm at E1.5 showed that this ectoderm is also not specified to differentiate into neurons at this stage. In addition, we demonstrate that non-neurogenic ectoderm from the trunk can give rise to nodose-type neurons when transplanted heterotopically to the nodose region.

scholarly journals Effects of Onchung-eum, an Herbal Prescription, on 5-Fluorouracil–Induced Oral Mucositis

2018 ◽  
Vol 17 (4) ◽  
pp. 1285-1296
Author(s):  
Jae-Woo Park ◽  
Jayoung Oh ◽  
Seok-Jae Ko ◽  
Mun Seog Chang ◽  
Jinsung Kim
Keyword(s):  
Inflammatory Cytokines ◽  
Oral Mucositis ◽  
Caspase 3 ◽  
Skin Diseases ◽  
Nuclear Factor Κb ◽  
Control Group ◽  
Nuclear Factor ◽  
Cheek Pouches ◽  
Herbal Prescription ◽  
Pro Inflammatory Cytokines

In most cancer patients, chemotherapy-induced oral mucositis (OM) is a frequent side effect, leading to low quality of life and delay in therapy. The aim of this study was to evaluate the effects of Onchung-eum, a well-known herbal prescription in traditional medicine comprising 8 herbs that has long been used for skin diseases, on 5-fluorouracil (5-FU)–induced OM in human pharyngeal cells and golden Syrian hamsters. DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, and reactive oxygen species production were measured in vitro. The effects of Onchung-eum on OM of hamster cheek pouches induced by 5-FU were evaluated histologically and using TUNEL assay. In addition, the expression of nuclear factor-κB, caspase-3, and pro-inflammatory cytokines were measured by immunoblotting and immunohistochemistry. Significantly increased cell viability was observed in the Onchung-eum–treated groups compared with the 5-FU–treated control group. In 500 and 1000 mg/kg Onchung-eum–treated groups, the damaged epithelial layers in the cheek pouches of hamsters were significantly recovered. Moreover, at all concentrations, cell death in the cheek pouches of hamsters in the Onchung-eum–treated groups significantly decreased. The expression of pro-inflammatory cytokines, nuclear factor-κB, and caspase-3 also significantly decreased in Onchung-eum–treated groups at 500 and 1000 mg/kg. In conclusion, this study revealed that Onchung-eum can be used to treat chemotherapy-induced OM. However, further studies are required to understand the underlying mechanisms.

PD36-10 MICROANATOMY AND INNERVATION PATTERNS OF THE SPERMATIC CORD IN HUMANS

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Koji Shiraishi ◽  
Shintaro Oka ◽  
Hideyasu Matsuyama
Keyword(s):  
Spermatic Cord ◽  
Innervation Patterns

Afferent Innervation Patterns of the Saccule in Pigeons

2003 ◽  
Vol 89 (1) ◽  
pp. 534-550 ◽  
Author(s):  
M. Zakir ◽  
D. Huss ◽  
J. D. Dickman
Keyword(s):  
Hair Cells ◽  
Three Dimensional ◽  
Otolith Organs ◽  
Type I ◽  
Innervation Patterns ◽  
Receptor Organ ◽  
Oriented Parallel ◽  
Biotinylated Dextran ◽  
Afferent Innervation ◽  
Anterior Posterior

The innervation patterns of vestibular saccular afferents were quantitatively investigated in pigeons using biotinylated dextran amine as a neural tracer and three-dimensional computer reconstruction. Type I hair cells were found throughout a large portion of the macula, with the highest density observed in the striola. Type II hair cells were located throughout the macula, with the highest density in the extrastriola. Three classes of afferent innervation patterns were observed, including calyx, dimorph, and bouton units, with 137 afferents being anatomically reconstructed and used for quantitative comparisons. Calyx afferents were located primarily in the striola, innervated a number of type I hair cells, and had small innervation areas. Most calyx afferent terminal fields were oriented parallel to the anterior-posterior axis and the morphological polarization reversal line. Dimorph afferents were located throughout the macula, contained fewer type I hair cells in a calyceal terminal than calyx afferents and had medium sized innervation areas. Bouton afferents were restricted to the extrastriola, with multi-branching fibers and large innervation areas. Most of the dimorph and bouton afferents had innervation fields that were oriented dorso-ventrally but were parallel to the neighboring reversal line. The organizational morphology of the saccule was found to be distinctly different from that of the avian utricle or lagena otolith organs and appears to represent a receptor organ undergoing evolutionary adaptation toward sensing linear motion in terrestrial and aerial species.

Lipoxygenase inhibitors block O2 responses of hamster cheek pouch arterioles

1988 ◽  
Vol 255 (4) ◽  
pp. H711-H716 ◽  
Author(s):  
W. F. Jackson
Keyword(s):  
Oxygen Tension ◽  
Nordihydroguaiaretic Acid ◽  
Cheek Pouch ◽  
Biochemical Pathway ◽  
Adrenergic Agonist ◽  
Hamster Cheek Pouch ◽  
Lipoxygenase Inhibitors ◽  
Cheek Pouches ◽  
Oxygen Reactivity

The hypothesis that a lipoxygenase is involved in arteriolar oxygen reactivity was tested in the superfused hamster cheek pouch preparation by assessment of the effects of three lipoxygenase inhibitors on the response of arterioles to changes in superfusate PO2. Superfusion of hamster cheek pouches with nordihydroguaiaretic acid (NDGA), 5,8,11,14-eicosatetraynoic acid (20 microM ETYA), or 100 microM 1-phenyl-3-pyrazolidone (phenidone) decreased (10 microM NDGA) or eliminated (30 microM NDGA, ETYA, or phenidone) the constriction of arterioles induced by elevation of superfusate oxygen tension. The response of the arterioles to the alpha 1-adrenergic agonist phenylephrine was not significantly affected by these inhibitors, an indication that the decreased oxygen response was not due to a nonspecific decrease in arteriolar reactivity. These data suggest that arteriolar oxygen reactivity in the hamster cheek pouch might involve a lipoxygenase or other noncyclooxygenase oxygen-dependent biochemical pathway that can be inhibited by NDGA, ETYA, and phenidone.

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