scholarly journals Reduction in Peanut Reaction Severity During Oral Challenge After 12 Months of Epicutaneous Immunotherapy

Allergy ◽  
2021 ◽  
Author(s):  
Philippe Bégin ◽  
J. Andrew Bird ◽  
Jonathan M. Spergel ◽  
Dianne E. Campbell ◽  
Todd D. Green ◽  
...  
Keyword(s):  
Oral Challenge ◽  
Epicutaneous Immunotherapy ◽  
Reaction Severity

A study of the state of implementation of oral challenge testing for food allergies

2014 ◽  
Vol 28 (3) ◽  
pp. 356-363
Author(s):  
Seigo Korematsu ◽  
Masafumi Zaitsu ◽  
Michiko Fujitaka ◽  
Kazuyo Kuzume ◽  
Mika Ogata ◽  
...  
Keyword(s):  
The State ◽  
Oral Challenge ◽  
Food Allergies ◽  
Challenge Testing

scholarly journals PEMCRC anaphylaxis study protocol: a multicentre cohort study to derive and validate clinical decision models for the emergency department management of children with anaphylaxis

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e037341
Author(s):  
Timothy E Dribin ◽  
Kenneth A Michelson ◽  
David Vyles ◽  
Mark I Neuman ◽  
David C Brousseau ◽  
...  
Keyword(s):  
Risk Factors ◽  
Emergency Department ◽  
Online Education ◽  
Prediction Models ◽  
Recursive Partitioning ◽  
Clinical Decision ◽  
Pediatric Emergency ◽  
Initial Reaction ◽  
Research Committee ◽  
Reaction Severity

IntroductionThere remain significant knowledge gaps about the management and outcomes of children with anaphylaxis. These gaps have led to practice variation regarding decisions to hospitalise children and length of observation periods following treatment with epinephrine. The objectives of this multicentre study are to (1) determine the prevalence of and risk factors for severe, persistent, refractory and biphasic anaphylaxis, as well as persistent and biphasic non-anaphylactic reactions; (2) derive and validate prediction models for emergency department (ED) discharge; and (3) determine data-driven lengths of ED and inpatient observation prior to discharge to home based on initial reaction severity.Methods and analysisThe study is being conducted through the Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC). Children 6 months to less than 18 years of age presenting to 30 participating EDs for anaphylaxis from October 2015 to December 2019 will be eligible. The primary outcomes for each objective are (1) severe, persistent, refractory or biphasic anaphylaxis, as well as persistent or biphasic non-anaphylactic reactions; (2) safe ED discharge, defined as no receipt of acute anaphylaxis medications or hypotension beyond 4 hours from first administered dose of epinephrine; and (3) time from first to last administered dose of epinephrine and vasopressor cessation. Analyses for each objective include (1) descriptive statistics to estimate prevalence and generalised estimating equations that will be used to investigate risk factors for anaphylaxis outcomes, (2) least absolute shrinkage and selection operator regression and binary recursive partitioning to derive and validate prediction models of children who may be candidates for safe ED discharge, and (3) Kaplan-Meier analyses to assess timing from first to last epinephrine doses and vasopressor cessation based on initial reaction severity.Ethics and disseminationAll sites will obtain institutional review board approval; results will be published in peer-reviewed journals and disseminated via traditional and social media, blogs and online education platforms.

scholarly journals Role of Multiple Comorbidities and Therapies in Conditioning the Clinical Severity of DRESS: A Mono-Center Retrospective Study of 25 Cases

2021 ◽  
Vol 22 (13) ◽  
pp. 7072
Author(s):  
Andrea Toniato ◽  
Chiara Gamba ◽  
Jan Walter Schroeder ◽  
Valeria Fabbri ◽  
Scarlett Valeria Bernal Ortiz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Reaction ◽  
Retrospective Study ◽  
Clinical Severity ◽  
Severe Reaction ◽  
Skin Involvement ◽  
Inflammatory State ◽  
Reaction Severity ◽  
Clinical Conditions

DRESS/DiHS is a complex and potentially fatal drug reaction. Little is known about risk factors and elements that can help to identify patients with a severe reaction early. The aim of the study was to investigate those factors favoring the disease and its severity by analyzing the clinical conditions and therapies preceding the reaction. We conducted a retrospective analysis on patients admitted to our center between 2010 and 2020 who were discharged with a diagnosis of DRESS. We used the RegiSCAR diagnostic criteria. We defined the severity of DRESS using the criteria of Mizukawa et al. We included 25 patients (15 females) with a median age of 66 years. Skin involvement, eosinophilia, and liver injury were the most important aspects. Allopurinol was found to be the most involved drug. Reaction severity was significantly associated with the number of daily medications (p=0.0067) and an age of at least 68 years (p=0.013). In addition, 75% of severe cases had at least three comorbidities in history, and most of the severe cases were female. In our study the advanced age, the high number of comorbidities and home therapies, and the inflammatory state were found to be predisposing elements to the development of the disease and its severity.

scholarly journals In pediatric patients who have penicillin skin testing with minor determinants, an oral challenge isn't needed

2021 ◽  
Vol 147 (2) ◽  
pp. AB5
Author(s):  
Michael D'Netto ◽  
Dayne Voelker ◽  
Miguel Park
Keyword(s):  
Pediatric Patients ◽  
Skin Testing ◽  
Oral Challenge

Triamcinolone pretreatment decreases skin reaction severity seen with transdermal testosterone,

1998 ◽  
Vol &NA; (703) ◽  
pp. 4
Author(s):  
&NA;
Keyword(s):  
Skin Reaction ◽  
Reaction Severity

scholarly journals Sustained unresponsiveness to peanut after long-term peanut epicutaneous immunotherapy

2020 ◽  
Author(s):  
Terri F. Brown-Whitehorn ◽  
Frédéric de Blay ◽  
Jonathan M. Spergel ◽  
Todd D. Green ◽  
Aurélie Peillon ◽  
...  
Keyword(s):  
Epicutaneous Immunotherapy ◽  
Sustained Unresponsiveness

scholarly journals Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Nathália Vieira Batista ◽  
Roberta Cristelli Fonseca ◽  
Denise Perez ◽  
Rafaela Vaz Sousa Pereira ◽  
Juliana de Lima Alves ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Food Allergy ◽  
Inflammatory Process ◽  
Platelet Activating Factor ◽  
Oral Challenge ◽  
Tissue Loss ◽  
Lack Of Information ◽  
Paf Receptor ◽  
Rolling Leukocytes

Platelet-activating factor (PAF) is known to be an important mediator of anaphylaxis. However, there is a lack of information in the literature about the role of PAF in food allergy. The aim of this work was to elucidate the participation of PAF during food allergy development and the consequent adipose tissue inflammation along with its alterations. Our data demonstrated that, both before oral challenge and after 7 days receiving ovalbumin (OVA) diet, OVA-sensitized mice lacking the PAF receptor (PAFR) showed a decreased level of anti-OVA IgE associated with attenuated allergic markers in comparison to wild type (WT) mice. Moreover, there was less body weight and adipose tissue loss in PAFR-deficient mice. However, some features of inflamed adipose tissue presented by sensitized PAFR-deficient and WT mice after oral challenge were similar, such as a higher rate of rolling leukocytes in this tissue and lower circulating levels of adipokines (resistin and adiponectin) in comparison to nonsensitized mice. Therefore, PAF signaling through PAFR is important for the allergic response to OVA but not for the adipokine alterations caused by this inflammatory process. Our work clarifies some effects of PAF during food allergy along with its role on the metabolic consequences of this inflammatory process.

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