Alteration of sperm parameters and reproductive hormones in Swiss mice via oxidative stress after co‐exposure to titanium dioxide and zinc oxide nanoparticles

Andrologia ◽  
2020 ◽  
Vol 52 (10) ◽  
Author(s):  
Opeoluwa M. Ogunsuyi ◽  
Olusegun I. Ogunsuyi ◽  
Olubukola Akanni ◽  
Okunola A. Alabi ◽  
Chibuisi G. Alimba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Titanium Dioxide ◽  
Zinc Oxide Nanoparticles ◽  
Reproductive Hormones ◽  
Sperm Parameters ◽  
Oxide Nanoparticles ◽  
Swiss Mice

scholarly journals Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration

2013 ◽  
Vol 10 (1) ◽  
pp. 9 ◽  
Author(s):  
Wan-Seob Cho ◽  
Byeong-Cheol Kang ◽  
Jong Kwon Lee ◽  
Jayoung Jeong ◽  
Jeong-Hwan Che ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Titanium Dioxide ◽  
Oral Administration ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles

Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus

2020 ◽  
Vol 154 ◽  
pp. 111078 ◽  
Author(s):  
Stella W.Y. Wong ◽  
Guang-Jie Zhou ◽  
Priscilla T.Y. Leung ◽  
Jeonghoon Han ◽  
Jae-Seong Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Tigriopus Japonicus ◽  
Marine Copepod ◽  
Copepod Tigriopus Japonicus

scholarly journals Silver, titanium dioxide, and zinc oxide nanoparticles trigger miRNA/isomiR expression changes in THP-1 cells that are proportional to their health hazard potential

2019 ◽  
Vol 13 (10) ◽  
pp. 1380-1395 ◽  
Author(s):  
Joseph Ndika ◽  
Umair Seemab ◽  
Wing-Lam Poon ◽  
Vittorio Fortino ◽  
Hani El-Nezami ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Titanium Dioxide ◽  
Zinc Oxide Nanoparticles ◽  
Health Hazard ◽  
Oxide Nanoparticles ◽  
Hazard Potential

scholarly journals The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro

Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4062
Author(s):  
Till Jasper Meyer ◽  
Agmal Scherzad ◽  
Helena Moratin ◽  
Thomas Eckert Gehrke ◽  
Julian Killisperger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxidative Dna Damage ◽  
Clonogenic Survival ◽  
Oxide Nanoparticles ◽  
Radiosensitizing Effect ◽  
Primary Fibroblasts

Radioresistance is an important cause of head and neck cancer therapy failure. Zinc oxide nanoparticles (ZnO-NP) mediate tumor-selective toxic effects. The aim of this study was to evaluate the potential for radiosensitization of ZnO-NP. The dose-dependent cytotoxicity of ZnO-NP20 nm and ZnO-NP100 nm was investigated in FaDu and primary fibroblasts (FB) by an MTT assay. The clonogenic survival assay was used to evaluate the effects of ZnO-NP alone and in combination with irradiation on FB and FaDu. A formamidopyrimidine-DNA glycosylase (FPG)-modified single-cell microgel electrophoresis (comet) assay was applied to detect oxidative DNA damage in FB as a function of ZnO-NP and irradiation exposure. A significantly increased cytotoxicity after FaDu exposure to ZnO-NP20 nm or ZnO-NP100 nm was observed in a concentration of 10 µg/mL or 1 µg/mL respectively in 30 µg/mL of ZnO-NP20 nm or 20 µg/mL of ZnO-NP100 nm in FB. The addition of 1, 5, or 10 µg/mL ZnO-NP20 nm or ZnO-NP100 nm significantly reduced the clonogenic survival of FaDu after irradiation. The sub-cytotoxic dosage of ZnO-NP100 nm increased the oxidative DNA damage compared to the irradiated control. This effect was not significant for ZnO-NP20 nm. ZnO-NP showed radiosensitizing properties in the sub-cytotoxic dosage. At least for the ZnO-NP100 nm, an increased level of oxidative stress is a possible mechanism of the radiosensitizing effect.

Genotoxicity evaluation of zinc oxide nanoparticles in Swiss mice after oral administration using chromosomal aberration, micronuclei, semen analysis, and RAPD profile

2017 ◽  
Vol 33 (11) ◽  
pp. 821-834 ◽  
Author(s):  
Anurag Kumar Srivastav ◽  
Akhilesh Kumar ◽  
Jyoti Prakash ◽  
Dhirendra Singh ◽  
Pankaj Jagdale ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Oral Administration ◽  
Chromosomal Aberration ◽  
Zinc Oxide Nanoparticles ◽  
Dose Group ◽  
High Dose Group ◽  
Oxide Nanoparticles ◽  
High Dose ◽  
Zno Nps ◽  
Swiss Mice

The expanded uses of zinc oxide nanoparticles (ZnO NPs) have grown rapidly in the field of nanotechnology. Thus, rising production of nanoparticles (NPs) increases the possible risks to the environment and occupationally exposed humans. Hence, it is indispensable to appraise the safety toxicity including genotoxicity for these NPs. In the present study, we have evaluated the genotoxic effect of ZnO NPs after oral administration to Swiss mice at dose levels of 300 and 2000 mg/kg body weight. These doses were administered for 2 days at 24 h apart. Chromosomal aberration (CA) and micronucleus tests were conducted following Organization for Economic Co-operation and Development guidelines. DNA damage was evaluated at 0, 24, 48, and 72 h posttreatment using a randomly amplified polymorphic DNA (RAPD) assay; additionally, semen analyses were also performed at 34.5 days post oral exposure. The reactive oxygen species (ROS), 8-oxo-2′-deoxyguanosine and CAs were increased ( p < 0.05) at the highest dosage (2000 mg/kg) of ZnO NPs compared to controls. Aberrant sperm morphology with reduced sperm count and motility were also present ( p < 0.05) in the high-dose group. Based on the RAPD assay, the genomic template stability within the high-dose group (<90%) was less than the controls (100%). The results suggested that ZnO NPs are mildly genotoxic in a dose-related manner and this toxicity were induced by generation of ROS.

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