The relationship between serum irisin levels and erectile dysfunction in diabetic men (irisin and erectile dysfunction in diabetic patients)

Objectives: Diabetic patients are often diagnosed with several comorbidities. The aim of the present study was to investigate the relationship between different combinations of risk factors and complications in diabetic patients. Research design and methods: We used a longitudinal, population-wide dataset of patients with hospital diagnoses and identified all patients (n = 195,575) receiving a diagnosis of diabetes in the observation period from 2003–2014. We defined nine ICD-10-codes as risk factors and 16 ICD-10 codes as complications. Using a computational algorithm, cohort patients were assigned to clusters based on the risk factors they were diagnosed with. The clusters were defined so that the patients assigned to them developed similar complications. Complication risk was quantified in terms of relative risk (RR) compared with healthy control patients. Results: We identified five clusters associated with an increased risk of complications. A combined diagnosis of arterial hypertension (aHTN) and dyslipidemia was shared by all clusters and expressed a baseline of increased risk. Additional diagnosis of (1) smoking, (2) depression, (3) liver disease, or (4) obesity made up the other four clusters and further increased the risk of complications. Cluster 9 (aHTN, dyslipidemia and depression) represented diabetic patients at high risk of angina pectoris “AP” (RR: 7.35, CI: 6.74–8.01), kidney disease (RR: 3.18, CI: 3.04–3.32), polyneuropathy (RR: 4.80, CI: 4.23–5.45), and stroke (RR: 4.32, CI: 3.95–4.71), whereas cluster 10 (aHTN, dyslipidemia and smoking) identified patients with the highest risk of AP (RR: 10.10, CI: 9.28–10.98), atherosclerosis (RR: 4.07, CI: 3.84–4.31), and loss of extremities (RR: 4.21, CI: 1.5–11.84) compared to the controls. Conclusions: A comorbidity of aHTN and dyslipidemia was shown to be associated with diabetic complications across all risk-clusters. This effect was amplified by a combination with either depression, smoking, obesity, or non-specific liver disease.

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THE RELATIONSHIP BETWEEN MEAN PLATELET VOLUME AND SERUM IL-6 LEVELS IN TYPE 2 DIABETIC PATIENTS AFTER SURGICAL OPERATION

Atherosclerosis Supplements ◽

10.1016/s1567-5688(08)71048-1 ◽

2008 ◽

Vol 9 (1) ◽

pp. 260

Author(s):

H. Terekeci ◽

C. Top ◽

B. Sahan ◽

M.E. Onde ◽

A.K. Gurbuz

Keyword(s):

Mean Platelet Volume ◽

Diabetic Patients ◽

Surgical Operation ◽

Platelet Volume ◽

Type 2 Diabetic Patients ◽

The Relationship ◽

Type 2 Diabetic

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The relationship between erectile dysfunction and lower urinary tract symptoms: Epidemiological, clinical, and basic science evidence

Current Urology Reports ◽

10.1007/s11934-004-0047-1 ◽

2004 ◽

Vol 5 (4) ◽

pp. 251-257 ◽

Cited By ~ 50

Author(s):

Kevin T. McVary ◽

Kevin E. McKenna

Keyword(s):

Erectile Dysfunction ◽

Urinary Tract ◽

Lower Urinary Tract Symptoms ◽

Basic Science ◽

Lower Urinary Tract ◽

Urinary Tract Symptoms ◽

The Relationship ◽

Science Evidence ◽

Lower Urinary

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P-244 - On the relationship between coping strategies and mental health of diabetic patients

European Psychiatry ◽

10.1016/s0924-9338(12)74411-5 ◽

2012 ◽

Vol 27 ◽

pp. 1

Author(s):

F. Sadeghi Movahhed ◽

E. Rezaei Ghalechi

Keyword(s):

Mental Health ◽

Coping Strategies ◽

Diabetic Patients ◽

The Relationship

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Relation Between Erectile Dysfunction and Silent Myocardial Ischemia in Diabetic Patients: A Multidetector Computed Tomographic Coronary Angiographic Study

Sexual Medicine ◽

10.1016/j.esxm.2016.04.005 ◽

2016 ◽

Vol 4 (3) ◽

pp. e127-e134 ◽

Cited By ~ 1

Author(s):

Amr Abdelhamed ◽

Shin-ichi Hisasue ◽

Essam A. Nada ◽

Ali M. Kassem ◽

Mohammed Abdel-Kareem ◽

...

Keyword(s):

Erectile Dysfunction ◽

Myocardial Ischemia ◽

Silent Myocardial Ischemia ◽

Diabetic Patients ◽

Angiographic Study ◽

Computed Tomographic

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Continuous ambulatory peritoneal dialysis in diabetic patients. The relationship of hypertension to retinopathy and cardiovascular complications.

Hypertension ◽

10.1161/01.hyp.7.6_pt_2.ii125 ◽

1985 ◽

Vol 7 (6_pt_2) ◽

Author(s):

J Rottembourg ◽

M Remaoun ◽

K Maiga ◽

P Bellio ◽

B Issad ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Cardiovascular Complications ◽

Diabetic Patients ◽

Relationship Of ◽

The Relationship

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The Relationship Between Plasma MMP-9 and TIMP-2 Levels and Intraocular Pressure Elevation in Diabetic Patients After Intravitreal Triamcinolone Injection

Journal of Glaucoma ◽

10.1097/ijg.0b013e31815c3a07 ◽

2008 ◽

Vol 17 (4) ◽

pp. 253-256 ◽

Cited By ~ 7

Author(s):

Nilgun Yildirim ◽

Afsun Sahin ◽

Nazmiye Erol ◽

Selcuk Kara ◽

Sema Uslu ◽

...

Keyword(s):

Intraocular Pressure ◽

Diabetic Patients ◽

Intravitreal Triamcinolone ◽

Pressure Elevation ◽

Intraocular Pressure Elevation ◽

Triamcinolone Injection ◽

Intravitreal Triamcinolone Injection ◽

The Relationship

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Abstract 18907: Relationships Between Renal Haemodynamics With Cardiac and Aortic Haemodynamics in the Early Stages of Essential Hypertension

Circulation ◽

10.1161/circ.130.suppl_2.18907 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Konstantinos Kintis ◽

Costas Tsioufis ◽

Anastasia Mazaraki ◽

Evaggelia Koutra ◽

Lefki Nikolopoulou ◽

...

Keyword(s):

Essential Hypertension ◽

Augmentation Index ◽

Resistive Index ◽

Renal Haemodynamics ◽

Renal Resistive Index ◽

Diabetic Patients ◽

Diastolic Velocity ◽

Relationship Of ◽

The Relationship ◽

Cardiac Haemodynamics

Introduction: The relationship of renal haemodynamics with cardiac and aortic hameodynamics is still unclear. Hypothesis: We evaluated the relationship of increased renal resistive index (RRI) with Augmentation index (AIx) and cardiac haemodynamics by means of mitral annular early diastolic velocity (E/Ea) in untreated patients with essential hypertension. Methods: 76 newly diagnosed untreated non diabetic patients with stage I-II essential hypertension [35 males, aged 50 years, office blood pressure (BP) = 143/ 91 mm Hg], underwent ABPM, complete echocardiographic study for determination of E/Ea and blood sampling for assessment of metabolic profile. Moreover, data on renal resistive index (RRI), obtained by Doppler ultrasound sampling of the intrarenal arteries, as well as augmentation index (AIx), were retrospectively analyzed. Results: Based on the mean value of RRI (0.60), hypertensives were classified into those with high and low RRI. Hypertensives with high RRI values compared to those with low values were older (55.6±9.8 vs 44.4±11.6 years, p < 0.001), had lower 24-hour diastolic BP (77.5±7.7 vs 84.3±6.7 mmHg, p < 0.001), lower 24-hour HR (71.2±10.3 vs 76.2±9.2 bpm, p < 0.05), higher levels of AIx (27.2±8.2 vs 17.8±14.8 %, p < 0.01), and higher values of E/Ea (lateral) (7.7±1.8 vs 6.2±2.3, p < 0.05). In the total population, RRI was negatively related to 24-hour diastolic BP (r = -0.523, p < 0.001) and 24-hour HR (r = -0.281, p < 0.05), while it was positively associated with CRP (r = 0.335, p < 0.05), TChol (r = 0.296, p < 0.01), age (r = 0.443, r < 0.001), AIx (r = 0.413, p = 0.001) and E/Ea(lateral) (r = 0.465, p < 0.05). Multiple regression analysis revealed that 24-hour diastolic BP and E/Ea (lateral) were independent associated with RRI (R2 = 0.434, p < 0.05). Conclusions: Increased vascular resistance of intrarenal arteries is associated with impaired aortic and cardiac haemodynamics, as reflected by increased AIx and E/Ea (lateral) values. RRI may be considered a useful surrogate of haemodynamics in essential hypertension.

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