Erectile dysfunction resulting from pelvic surgery is associated with changes in cavernosal gene expression indicative of cavernous nerve injury

Andrologia ◽  
2021 ◽  
Author(s):  
Guillermo Villegas ◽  
Moses Tarndie Tar ◽  
Kelvin Paul Davies
Keyword(s):  
Gene Expression ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Pelvic Surgery ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

scholarly journals Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Nan Jiang ◽  
Cheng Wu ◽  
Xunrong Zhou ◽  
Guanghua Zhai ◽  
Jian Wu
Keyword(s):  
Prostate Cancer ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Basic Research ◽  
Cancer Surgery ◽  
Pelvic Surgery ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

Erectile dysfunction (ED) is an important cause of reduced quality of life for men and their partners. Recent studies have found that cavernous nerve injury (CNI) during prostate cancer surgery and other pelvic surgery results in medically induced CNIED in more than 80% of patients. The efficacy of first- and second-line treatment options for ED is poor. A great deal of research has been devoted to exploring new methods of neuroprotection and nerve regeneration to save erectile function in patients with CNIED, especially in patients with cavernous nerve injury after prostate cancer surgery. In addition, such as neuromodulatory proteins, proimmune ligands, gene therapy, stem cell therapy, and the current cutting-edge low-energy shock wave therapy have shown advantages in basic research and limited clinical studies. In the context of today’s modern medicine, these new therapeutic techniques are expected to be new tools in the treatment of cavernous nerve injury erectile dysfunction. This article presents the main causes, mechanisms, and treatment of cavernous nerve injury erectile dysfunction and combines them with new treatment strategies.

scholarly journals Gene expression profile comparison in the penile tissue of diabetes and cavernous nerve injury-induced erectile dysfunction rat model

2016 ◽  
Vol 57 (4) ◽  
pp. 286 ◽  
Author(s):  
Sung Chul Kam ◽  
Sang Hoon Lee ◽  
Ju Hong Jeon ◽  
Insuk So ◽  
Mee Ree Chae ◽  
...  
Keyword(s):  
Gene Expression ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Rat Model ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

671: Prophylactic use of the Parp1 Inhibitor INO-1002 Prevents Erectile Dysfunction Due to Cavernous Nerve Injury in Rats

2007 ◽  
Vol 177 (4S) ◽  
pp. 225-225
Author(s):  
Muammer Kendirci ◽  
Landon Trost ◽  
Wayne J.G. Hellstrom
Keyword(s):  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Cavernous Nerve ◽  
Prophylactic Use ◽  
Cavernous Nerve Injury

Cavernous Nerve Injury by Radiation Therapy May Potentiate Erectile Dysfunction in Rats

2017 ◽  
Vol 99 (3) ◽  
pp. 680-688 ◽  
Author(s):  
Javed Mahmood ◽  
Caroline Q. Connors ◽  
Allen A. Alexander ◽  
Radmila Pavlovic ◽  
Santanu Samanta ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

1023 INVOLVEMENT OF RHO-KINASE/LIM-KINASE/COFILIN SIGNALING PATHWAY IN ERECTILE DYSFUNCTION AND CORPORAL FIBROSIS AFTER CAVERNOUS NERVE INJURY IN MALE RATS

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Min Chul Cho ◽  
Sang Hoon Song ◽  
Sung Yong Cho ◽  
Kwanjin Park ◽  
Soo Woong Kim ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Signaling Pathway ◽  
Nerve Injury ◽  
Rho Kinase ◽  
Male Rats ◽  
Lim Kinase ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

scholarly journals Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury

Theranostics ◽  
2019 ◽  
Vol 9 (22) ◽  
pp. 6354-6368 ◽  
Author(s):  
Zehong Chen ◽  
Xiaoyan Han ◽  
Xi Ouyang ◽  
Jiafeng Fang ◽  
Xuna Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Cavernous Nerve ◽  
Induced Pluripotent ◽  
Cavernous Nerve Injury

Administration of H2S improves erectile dysfunction by inhibiting phenotypic modulation of corpus cavernosum smooth muscle in bilateral cavernous nerve injury rats

Nitric Oxide ◽  
2021 ◽  
Vol 107 ◽  
pp. 1-10
Author(s):  
Qinyu-Zeng ◽  
Shuhua-He ◽  
Fengzhi-Chen ◽  
Li-Wang ◽  
Liren-Zhong ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Corpus Cavernosum ◽  
Phenotypic Modulation ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

Ziziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury‐induced erectile dysfunction in a rat model

Andrologia ◽  
2020 ◽  
Vol 52 (7) ◽  
Author(s):  
Sefa Resim ◽  
Eyüp Koluş ◽  
Osman Barut ◽  
Faruk Kucukdurmaz ◽  
Abdulkadir Yasir Bahar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Rat Model ◽  
Cavernous Nerve ◽  
Ziziphus Jujube ◽  
Cavernous Nerve Injury
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