Inhibition of gap junction communication between cells can induce apoptosis of corpus cavernosum smooth muscle in guinea pigs

Andrologia ◽  
2021 ◽  
Author(s):  
Yuan Wang ◽  
Jingshen Wang ◽  
Zhiqiang Hao ◽  
Heng Yang ◽  
Yongle Li ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Gap Junction ◽  
Guinea Pigs ◽  
Corpus Cavernosum ◽  
Gap Junction Communication

Effect of platelet-derived growth factor-BB on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells

Andrologia ◽  
2018 ◽  
Vol 51 (3) ◽  
pp. e13200 ◽  
Author(s):  
Fan Zhao ◽  
Junfeng Yan ◽  
Jianfeng Zhao ◽  
Bing Shi ◽  
Miaoyong Ye ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Gap Junction ◽  
Corpus Cavernosum ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor

Changes of gap junctions in myometrium of guinea pig at parturition and abortion

1982 ◽  
Vol 60 (3) ◽  
pp. 335-341 ◽  
Author(s):  
R. E. Garfield ◽  
E. E. Daniel ◽  
M. Dukes ◽  
J. D. Fitzgerald
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Gap Junctions ◽  
Gap Junction ◽  
Electron Micrographs ◽  
Guinea Pigs ◽  
Muscle Cells ◽  
Similar Increase ◽  
Junction Area

Myometrial tissues from guinea pigs were quantitatively examined for gap junctions in electron micrographs. Small numbers of gap junctions were present between smooth muscle cells in myometria of pregnant guinea pigs at days 50 and 65 of gestation. The junctions increased in number and size at parturition on day 69 and decreased again to control levels 24 h after parturition. A similar increase in junctions occurred when abortion was induced by 16,16-dimethylprostaglandin E2 (PGE2) on day 65. There were no consistent or significant differences in numbers of gap junctions from myometrium taken over sites of placental attachment and from other sites. These results together with previous studies suggest that an increase in myometrial gap junction area is associated with and may be essential for parturition in guinea pigs, but the control of their development may differ from that in other mammals.

scholarly journals Cytokine Effects on Gap Junction Communication and Connexin Expression in Human Bladder Smooth Muscle Cells and Suburothelial Myofibroblasts

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20792 ◽  
Author(s):  
Marco Heinrich ◽  
Andreas Oberbach ◽  
Nadine Schlichting ◽  
Jens-Uwe Stolzenburg ◽  
Jochen Neuhaus
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Gap Junction ◽  
Muscle Cells ◽  
Bladder Smooth Muscle ◽  
Human Bladder ◽  
Connexin Expression ◽  
Gap Junction Communication

Density and distribution of connexin 43 in corpus cavernosum tissue from diabetic and hypogonadal patients with erectile dysfunction

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Abdulmaged M. Traish ◽  
Casey Stottrup ◽  
Koenraad van Renterghem ◽  
Ruth Achten ◽  
Sayon Roy
Keyword(s):  
Smooth Muscle ◽  
Erectile Dysfunction ◽  
Gap Junction ◽  
Connexin 43 ◽  
Unit Area ◽  
Corpus Cavernosum ◽  
Normal Subjects ◽  
Cumulative Number ◽  
Tissue Samples ◽  
Junction Protein

AbstractAltered expression of connexin 43 (Cx43) has been postulated to be involved in the development and progression of various diseases including erectile dysfunction (ED). The aim of this study was to determine whether distribution and density of the gap junction protein Cx43 are altered in human corpus cavernosum (HCC) tissue samples derived from diabetic or hypogonadal patients with ED compared to those from normal subjects.HCC tissue sections derived from normal, diabetic and hypogonadal subjects were fixed in 4% formaldehyde, embedded in paraffin and immunostained with a monoclonal mouse anti-rat Cx43 antibody. Cx43 density was expressed as the cumulative number of gap junction plaques per unit area of tissue corrected for number of 4′,6-diamidino-2-phenylindole, dihydrochloride-labeled smooth muscle cells (dots per unit area corrected for number of cells).The distribution of Cx43 plaques in smooth muscle was not affected in tissues derived from diabetic or hypogonadal subjects with ED compared with those from normal subjects. However, the number of Cx43 plaques was significantly reduced in HCC tissues derived from diabetic or hypogonadal subjects (73±8% and 68±11% of normal, respectively), indicating reduced Cx43 gap junctions in diabetic and hypogonadal subjects with ED.Cx43 density in the HCC was diminished in tissue samples derived from diabetic or hypogonadal patients with ED compared to tissue samples from normal non-diabetic subjects. This marked decrease in Cx43 gap junction channels may contribute to attenuated gap junction function and to diminished erectile physiology.

scholarly journals Traumatic Brain Injury In Vivo and In Vitro Contributes to Cerebral Vascular Dysfunction through Impaired Gap Junction Communication between Vascular Smooth Muscle Cells

2014 ◽  
Vol 31 (8) ◽  
pp. 739-748 ◽  
Author(s):  
Guang-Xiang Yu ◽  
Martin Mueller ◽  
Bridget E. Hawkins ◽  
Babu P. Mathew ◽  
Margaret A. Parsley ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Smooth Muscle ◽  
Brain Injury ◽  
Smooth Muscle Cells ◽  
Gap Junction ◽  
Vascular Smooth Muscle Cells ◽  
Vascular Dysfunction ◽  
Gap Junction Communication

1450: Diabetes-Related Alterations in Connexin43-Derived GAP Junction Permeability in Short Term Cultures of RAT Corporal Vascular Smooth Muscle Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 382-382
Author(s):  
George Christ ◽  
Hong-Zhan Wang ◽  
Vergas Valiunas ◽  
Peter Brink ◽  
Stony Brook
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Gap Junction ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Short Term

1429: Upregulation of Rho-Kinase in a Human Corpus Cavernosum Smooth Muscle Cell Line in Response to Hypoxia

2004 ◽  
Vol 171 (4S) ◽  
pp. 376-377
Author(s):  
Yongmu Zheng ◽  
Shaohua Chang ◽  
Alan J. Wein ◽  
Samuel Chacko ◽  
Michael E. DiSanto
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Line ◽  
Muscle Cell ◽  
Corpus Cavernosum ◽  
Rho Kinase ◽  
Muscle Cell Line
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