Perceived Parent and Peer Alienation and Its Relations to Anxiety Sensitivity, Pathological Worry, and Generalised Anxiety Disorder Symptoms

2016 ◽  
Vol 51 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Doris Curzik ◽  
Svjetlana Salkicevic
Keyword(s):  
Anxiety Disorder ◽  
Anxiety Sensitivity ◽  
Generalised Anxiety Disorder ◽  
Pathological Worry

scholarly journals Ventromedial prefrontal cortex activity and pathological worry in generalised anxiety disorder

2018 ◽  
Vol 213 (1) ◽  
pp. 437-443 ◽  
Author(s):  
E. Via ◽  
M. A. Fullana ◽  
X. Goldberg ◽  
D. Tinoco-González ◽  
I. Martínez-Zalacaín ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Anxiety Disorder ◽  
Emotional Processing ◽  
Qualitative Difference ◽  
Ventromedial Prefrontal Cortex ◽  
Generalised Anxiety Disorder ◽  
Conditioning Paradigm ◽  
Pathological Worry ◽  
Learned Safety ◽  
Hallmark Feature

BackgroundPathological worry is a hallmark feature of generalised anxiety disorder (GAD), associated with dysfunctional emotional processing. The ventromedial prefrontal cortex (vmPFC) is involved in the regulation of such processes, but the link between vmPFC emotional responses and pathological v. adaptive worry has not yet been examined.AimsTo study the association between worry and vmPFC activity evoked by the processing of learned safety and threat signals.MethodIn total, 27 unmedicated patients with GAD and 56 healthy controls (HC) underwent a differential fear conditioning paradigm during functional magnetic resonance imaging.ResultsCompared to HC, the GAD group demonstrated reduced vmPFC activation to safety signals and no safety–threat processing differentiation. This response was positively correlated with worry severity in GAD, whereas the same variables showed a negative and weak correlation in HC.ConclusionsPoor vmPFC safety–threat differentiation might characterise GAD, and its distinctive association with GAD worries suggests a neural-based qualitative difference between healthy and pathological worries.Declaration of interestNone.

scholarly journals The relationships between perfectionism, pathological worry and generalised anxiety disorder

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Alicia K Handley ◽  
Sarah J Egan ◽  
Robert T Kane ◽  
Clare S Rees
Keyword(s):  
Anxiety Disorder ◽  
Generalised Anxiety Disorder ◽  
Pathological Worry

765 Anxiety and sleep in Generalized Anxiety Disorder with and without Insomnia Disorder

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A298-A298
Author(s):  
Augustus Kram Mendelsohn ◽  
Carolina Daffre ◽  
Katelyn Oliver ◽  
Jeehye Seo ◽  
Natasha Lasko ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Anxiety Sensitivity ◽  
Slow Wave Sleep ◽  
Stress Test ◽  
Generalized Anxiety ◽  
Poor Sleep ◽  
Sensitivity Index ◽  
Somatic Anxiety ◽  
Insomnia Disorder

Abstract Introduction Insomnia Disorder (ID) elevates risk of incident anxiety disorders and vice versa. We examined whether ID and poor sleep are associated with greater self-reported anxiety in persons with Generalized Anxiety Disorder (GAD). Methods Twenty-one participants with GAD and ID (GAD+/ID+) having Insomnia Severity Index (ISI) scores ≥ 13 (mean 17.8, SD 3.6) and 14 with GAD but not ID (GAD+/ID-) having ISI scores ≤ 12 (mean 6.4, SD 3.4) completed 14 days of actigraphy and sleep diaries as well as a night of ambulatory polysomnography (PSG) following an acclimation night. Participants completed the Pittsburgh Sleep Quality Index (PSQI), the State-Trait Inventory for Cognitive and Somatic Anxiety (STICSA-T/C, -T/S), the Ford Insomnia Response to Stress Test (FIRST), the Penn State Worry Questionnaire (PSWQ), and the Anxiety Sensitivity Index (ASI). Differences in self-reported anxiety (STICSA, ASI, PSWQ) between GAD+/ID+ and GAD+/ID- were analyzed using t-tests. Relationships of anxiety with retrospective (PSQI, FIRST, ISI), longitudinal (actigraphy, diaries) and physiological (PSG) sleep variables were analyzed using simple regression. Results GAD+/ID+ versus GAD+/ID- participants showed trends toward higher anxiety on the PSWQ (p=0.075), ASI (p=0.072) and STICSA-T/S (p=0.078). PSQI scores were positively associated with STICSA-T/S, (R=0.417, p=0.018, N=32). Greater insomnia reactivity (FIRST) was associated with increased worry on the PSWQ (R=0.352, p=0.044, N=33). STICSA-T/C was negatively associated with mean diary (R= -0.440, p=0.015, N=30) and actigraph (R= -0.517, p=0.01, N=24) total sleep time (TST). Actigraph mean TST trended toward lower PSWQ (R= -0.376, p=0.058, N=26) while actigraph mean sleep efficiency (SE) trended toward lesser STICSA-T/C (R= -0.397, p=0.058). Greater REM% was associated with greater STICSA-T/C (R=0.613, p=0.0005, N=28) and STICSA-T/S (R=0.516, p=0.005), a relationship also seen in GAD+/ID+ alone (p=0.03 and 0.015 respectively, N=16). Slow Wave Sleep% (SWS%) was not associated with lesser STICSA-T/S across both groups (p=0.14) but was so in GAD+/ID+ (R= -0.539, p=0.031, N=16). Conclusion GAD+/ID+ versus GAD+/ID-, show greater worry, anxiety sensitivity and somatic anxiety. In GAD, shorter and poorer quality sleep measured retrospectively or averaged longitudinally, as well as greater REM%, are associated with greater somatic and cognitive anxiety. Among those with ID, greater SWS% is associated with less somatic anxiety. Support (if any) R21MH115279, R01MH109638

scholarly journals Generalised Anxiety Disorder and Depression on Implicit and Explicit Trust Tendencies Towards Automated Systems

IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Jordan R. Crawford ◽  
Yee Mey Goh ◽  
Ella-Mae Hubbard
Keyword(s):  
Anxiety Disorder ◽  
Generalised Anxiety Disorder ◽  
Automated Systems ◽  
Implicit And Explicit

Reported Early Separation Anxiety Symptoms in Patients with Panic and Generalised Anxiety Disorders

1993 ◽  
Vol 27 (3) ◽  
pp. 489-494 ◽  
Author(s):  
Derrick Silove ◽  
Vijaya Manicavasagar ◽  
Dianne O'connell ◽  
Alex Blaszczynski
Keyword(s):  
Risk Factor ◽  
Anxiety Disorder ◽  
Panic Disorder ◽  
Attachment Theory ◽  
Anxiety Symptom ◽  
Separation Anxiety ◽  
Empirical Studies ◽  
Generalised Anxiety Disorder ◽  
Early Separation ◽  
And Control

Attachment theory has proposed that early separation anxiety is a risk factor for adult anxiety disorder, with the recent focus being particularly on panic disorder. The results of empirical studies examining this link are, however, contradictory, possibly because of inconsistencies across studies in measuring memories of early separation anxiety. In the present study, a psychometrically sound measure, the Separation Anxiety Symptom Inventory (SASI) was used to compare memories of such early symptoms in panic disorder (including those with mild phobic-avoidance), generalised anxiety disorder and control subjects. Anxiety patients as a group returned higher SASI scores (p<0.001) with a non-significant trend for panic disorder patients to score higher than those with generalised anxiety. These results suggest that early separation anxiety may be a harbinger of adult anxiety and that risk of panic disorder may be higher in the most severely affected youngsters. As a risk factor, early separation anxiety does not however appear to be uniquely related to adult panic disorder.

Escitalopram prevents relapse in generalised anxiety disorder

2006 ◽  
Vol &NA; (1566) ◽  
pp. 13
Author(s):  
&NA;
Keyword(s):  
Anxiety Disorder ◽  
Generalised Anxiety Disorder

Generalised anxiety disorder

2002 ◽  
pp. 67-87
Author(s):  
Gérard Emilien ◽  
Timothy Dinan ◽  
Ulla Marjatta Lepola ◽  
Cécile Durlach
Keyword(s):  
Anxiety Disorder ◽  
Generalised Anxiety Disorder

Major Depression and Generalised Anxiety Disorder

1996 ◽  
Vol 168 (S30) ◽  
pp. 68-75 ◽  
Author(s):  
Kenneth S. Kendler
Keyword(s):  
Risk Factors ◽  
Anxiety Disorder ◽  
Major Depression ◽  
Environmental Risk ◽  
Genetic Factors ◽  
Environmental Risk Factors ◽  
Generalised Anxiety Disorder ◽  
Increase Risk ◽  
Twin Models ◽  
One Year

In both clinical and epidemiological samples, major depression (MD) and generalised anxiety disorder (GAD) display substantial comorbidity. In a prior analysis of lifetime MD and GAD in female twins, the same genetic factors were shown to influence the liability to MD and to GAD. A follow-up interview in the same twin cohort examined one-year prevalence for MD and GAD (diagnosed using a one-month minimum duration of illness). Bivariate twin models were fitted using the program Mx. High levels of comorbidity were observed between MD and GAD. The best-fitting twin models, when GAD was diagnosed with or without a diagnostic hierarchy, found a genetic correlation of unity between the two disorders. The correlation in environmental risk factors was +0.70 when GAD was diagnosed non-hierarchically, but zero when hierarchical diagnoses were used. Our findings provide further support for the hypothesis that in women, MD and GAD are the result of the same genetic factors. Environmental risk factors that predispose to ‘pure’ GAD episodes may be relatively distinct from those that increase risk for MD.

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