Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells

2015 ◽  
Vol 217 (1) ◽  
pp. 45-60 ◽  
Author(s):  
M. Hjorth ◽  
S. Pourteymour ◽  
S. W. Görgens ◽  
T. M. Langleite ◽  
S. Lee ◽  
...  
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells

scholarly journals The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ragna H. Tingstad ◽  
Frode Norheim ◽  
Fred Haugen ◽  
Yuan Z. Feng ◽  
Hege S. Tunsjø ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oleic Acid ◽  
Energy Metabolism ◽  
Glucose Metabolism ◽  
Human Skeletal Muscle ◽  
Acid Metabolism ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Metabolic Effects ◽  
Human Skeletal Muscle Cells

AbstractSkeletal muscle plays an important role in glycaemic control and metabolic homeostasis, making it a tissue of interest with respect to type 2 diabetes mellitus. The aim of the present study was to determine if ligands of Toll-like receptors (TLRs) could have an impact on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells. The myotubes expressed mRNA for TLRs 1–6. TLR3, TLR4, TLR5 and TLR6 ligands (TLRLs) increased glucose metabolism. Furthermore, TLR4L and TLR5L increased oleic acid metabolism. The metabolic effects of TLRLs were not evident until after at least 24 h pre-incubation of the cells and here the metabolic effects were more evident for the metabolism of glucose than oleic acid, with a shift towards effects on oleic acid metabolism after chronic exposure (168 h). However, the stimulatory effect of TLRLs on myokine expression and secretion was detected after only 6 h, where TLR3-6L stimulated secretion of interleukin-6 (IL-6). TLR5L also increased secretion of interleukin-8 (IL-8), while TLR6L also increased secretion of granulocyte–macrophage colony stimulating factor (GM-CSF). Pre-incubation of the myotubes with IL-6 for 24 h increased oleic acid oxidation but had no effect on glucose metabolism. Thus IL-6 did not mimic all the metabolic effects of the TLRLs, implying metabolic effects beyond the actions of this myokine.

scholarly journals The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells

2021 ◽  
Vol 2 ◽  
pp. 100060
Author(s):  
Abel M. Mengeste ◽  
Jenny Lund ◽  
Parmeshwar Katare ◽  
Roya Ghobadi ◽  
Hege G. Bakke ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Small Molecule ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells

scholarly journals Remodeling of Oxidative Energy Metabolism by Galactose Improves Glucose Handling and Metabolic Switching in Human Skeletal Muscle Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e59972 ◽  
Author(s):  
Eili Tranheim Kase ◽  
Nataša Nikolić ◽  
Siril Skaret Bakke ◽  
Kaja Kamilla Bogen ◽  
Vigdis Aas ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Metabolic Switching ◽  
Oxidative Energy Metabolism ◽  
Human Skeletal Muscle Cells

TGFß regulates metabolism of human skeletal muscle cells by miRNAs

2018 ◽  
Author(s):  
S Höckele ◽  
P Huypens ◽  
C Hoffmann ◽  
T Jeske ◽  
M Hastreiter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells

Telomerase Alone Extends the Replicative Life Span of Human Skeletal Muscle Cells Without Compromising Genomic Stability

2003 ◽  
Vol 14 (15) ◽  
pp. 1473-1487 ◽  
Author(s):  
Martha Wootton ◽  
Karen Steeghs ◽  
Diana Watt ◽  
June Munro ◽  
Katrina Gordon ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Life Span ◽  
Human Skeletal Muscle ◽  
Genomic Stability ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Replicative Life Span ◽  
Human Skeletal Muscle Cells

scholarly journals Effects of 1,25-Dihydroxyvitamin D3 and Vitamin D3 on the Expression of the Vitamin D Receptor in Human Skeletal Muscle Cells

2014 ◽  
Vol 96 (3) ◽  
pp. 256-263 ◽  
Author(s):  
Rachele M. Pojednic ◽  
Lisa Ceglia ◽  
Karl Olsson ◽  
Thomas Gustafsson ◽  
Alice H. Lichtenstein ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Human Skeletal Muscle Cells

scholarly journals Metabolomic analysis of primary human skeletal muscle cells during myogenic progression

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ashok Kumar ◽  
Yashwant Kumar ◽  
Jayesh Kumar Sevak ◽  
Sonu Kumar ◽  
Niraj Kumar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Metabolomic Analysis ◽  
Human Skeletal Muscle Cells
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