Cloning and characterization of microphthalmia‐associated transcription factor‐like gene provide insights into Cyclina sinensis clam shell melanin deposition

2021 ◽  
Author(s):  
Pan Qiu ◽  
Mingyue Zhang ◽  
Yuchen Wu ◽  
Yu Liu ◽  
Yiwo Wang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Clam Shell ◽  
Cyclina Sinensis

scholarly journals Mating Type in Chlamydomonas Is Specified by mid, the Minus-Dominance Gene

Genetics ◽  
1997 ◽  
Vol 146 (3) ◽  
pp. 859-869 ◽  
Author(s):  
Patrick J Ferris ◽  
Ursula W Goodenough
Keyword(s):  
Transcription Factor ◽  
Mating Type ◽  
Codon Bias ◽  
Leucine Zipper ◽  
Laboratory Strain ◽  
Leucine Zipper Motif ◽  
Type Locus ◽  
Diploid Cells ◽  
Necessary And Sufficient

Diploid cells of Chlamydomonas reinhardtii that are heterozygous at the mating-type locus (mt  +/mt  –) differentiate as minus gametes, a phenomenon known as minus dominance. We report the cloning and characterization of a gene that is necessary and sufficient to exert this minus dominance over the plus differentiation program. The gene, called mid, is located in the rearranged (R) domain of the mt  – locus, and has duplicated and transposed to an autosome in a laboratory strain. The imp11 mt  – mutant, which differentiates as a fusion-incompetent plus gamete, carries a point mutation in mid. Like the fus1 gene in the mt  + locus, mid displays low codon bias compared with other nuclear genes. The mid sequence carries a putative leucine zipper motif, suggesting that it functions as a transcription factor to switch on the minus program and switch off the plus program of gametic differentiation. This is the first sex-determination gene to be characterized in a green organism.

Characterization of a transcription factor SlNAC7 gene from Suaeda liaotungensis and its role in stress tolerance

2021 ◽  
Author(s):  
Hong-Fei Wang ◽  
Hong-Yan Shan ◽  
He Shi ◽  
Dan-Dan Wu ◽  
Tong-Tong Li ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stress Tolerance

scholarly journals Functional characterization of a new grapevine MYB transcription factor and regulation of proanthocyanidin biosynthesis in grapes

2014 ◽  
Vol 65 (15) ◽  
pp. 4433-4449 ◽  
Author(s):  
Kazuya Koyama ◽  
Mineyo Numata ◽  
Ikuko Nakajima ◽  
Nami Goto-Yamamoto ◽  
Hideo Matsumura ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Functional Characterization ◽  
Myb Transcription Factor

Biochemical and genetic characterization of the porcine Prophet of Pit-1 pituitary transcription factor

2000 ◽  
Vol 168 (1-2) ◽  
pp. 77-87 ◽  
Author(s):  
Kyle W. Sloop ◽  
Amy McCutchan Schiller ◽  
Timothy P.L. Smith ◽  
John R. Blanton ◽  
Gary A. Rohrer ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Genetic Characterization

scholarly journals Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2

1994 ◽  
Vol 269 (15) ◽  
pp. 11663-11671
Author(s):  
S.L. Swendeman ◽  
C. Spielholz ◽  
N.A. Jenkins ◽  
D.J. Gilbert ◽  
N.G. Copeland ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chromosomal Location ◽  
Genomic Structure ◽  
Alpha Globin

scholarly journals Identification of Potential Key lncRNAs in the Context of Mouse Myeloid Differentiation by Systematic Transcriptomics Analysis

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 630
Author(s):  
Yongqing Lan ◽  
Meng Li ◽  
Shuangli Mi
Keyword(s):  
Transcription Factor ◽  
Cell Model ◽  
Myeloid Differentiation ◽  
Rna Seq ◽  
Hematopoietic Differentiation ◽  
Granulocytic Differentiation ◽  
Expression Of Genes ◽  
Non Coding Rnas

Hematopoietic differentiation is a well-orchestrated process by many regulators such as transcription factor and long non-coding RNAs (lncRNAs). However, due to the large number of lncRNAs and the difficulty in determining their roles, the study of lncRNAs is a considerable challenge in hematopoietic differentiation. Here, through gene co-expression network analysis over RNA-seq data generated from representative types of mouse myeloid cells, we obtained a catalog of potential key lncRNAs in the context of mouse myeloid differentiation. Then, employing a widely used in vitro cell model, we screened a novel lncRNA, named Gdal1 (Granulocytic differentiation associated lncRNA 1), from this list and demonstrated that Gdal1 was required for granulocytic differentiation. Furthermore, knockdown of Cebpe, a principal transcription factor of granulocytic differentiation regulation, led to down-regulation of Gdal1, but not vice versa. In addition, expression of genes involved in myeloid differentiation and its regulation, such as Cebpa, were influenced in Gdal1 knockdown cells with differentiation blockage. We thus systematically identified myeloid differentiation associated lncRNAs and substantiated the identification by investigation of one of these lncRNAs on cellular phenotype and gene regulation levels. This study promotes our understanding of the regulation of myeloid differentiation and the characterization of roles of lncRNAs in hematopoietic system.

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