Effects of dietary phytol on tissue accumulation of phytanic acid and pristanic acid and on the tissue lipid profiles in mice

Diabetes is characterized by hyperglycaemia with alterations of lipid parameters. The effects of Aloe vera (A.V) gel extract on lipid profiles of streptozotocin-induced diabetic rats were investigated. Seventy-two male albino rats were randomly divided into six groups of 12 rats each; control, diabetic control, 4 ml/kg and 8 ml/kg body weight (b.w.) A.V, 10 mg/kg b.w. glibenclimide and non-diabetic 8 ml/kg b.w. A.V groups. They were treated for 14 and 28 days. The plasma and HDL lipid profiles (triacylglycerols, cholesterol and phospholipids) of the diabetic rats were significantly (p<0.05) increased, while those of the VLDL+LDL, RBC, RBC membrane and organs were observed to be significantly (p<0.05) reduced, when compared to the control after 14 and 28 days of treatment. A.V gel extract significantly (p<0.05) ameliorated the disruptions observed in the lipid profiles of the diabetic and thus provide a scientific rationale for the use of Aloe vera as a therapeutic agent.Bangladesh J Med Biochem 2016; 9(1): 11-26

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Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans

American Journal of Clinical Nutrition ◽

10.3945/ajcn.113.070557 ◽

2014 ◽

Vol 99 (3) ◽

pp. 436-445 ◽

Cited By ~ 45

Author(s):

C Lawrence Kien ◽

Janice Y Bunn ◽

Robert Stevens ◽

James Bain ◽

Olga Ikayeva ◽

...

Keyword(s):

Dietary Intake ◽

Lipid Profiles ◽

Tissue Lipid

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Concentrations of phytanic acid and pristanic acid are higher in organic than in conventional dairy products from the German market

Food Chemistry ◽

10.1016/j.foodchem.2009.07.027 ◽

2010 ◽

Vol 119 (2) ◽

pp. 746-752 ◽

Cited By ~ 43

Author(s):

Walter Vetter ◽

Markus Schröder

Keyword(s):

Dairy Products ◽

Phytanic Acid ◽

Pristanic Acid ◽

German Market

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Diagnosis of peroxisomal disorders by analysis of phytanic and pristanic acids in stored blood spots collected at neonatal screening

Clinical Chemistry ◽

10.1093/clinchem/39.9.1904 ◽

1993 ◽

Vol 39 (9) ◽

pp. 1904-1906 ◽

Cited By ~ 11

Author(s):

H J ten Brink ◽

C M van den Heuvel ◽

E Christensen ◽

C Largillière ◽

C Jakobs

Keyword(s):

Neonatal Screening ◽

Phytanic Acid ◽

Zellweger Syndrome ◽

Dried Blood Spots ◽

Chondrodysplasia Punctata ◽

Pristanic Acid ◽

Rhizomelic Chondrodysplasia Punctata ◽

Peroxisomal Disorders ◽

Blood Spots ◽

Blood Spot

Abstract Concentrations of phytanic acid and pristanic acid were measured in stored dried blood spots collected at neonatal screening from patients with peroxisomal disorders, and compared with concentrations in control blood spots. In blood spots from two patients with Zellweger syndrome both phytanic acid and pristanic acid concentrations were increased but their concentration ratio was normal. In the blood spot from a patient with rhizomelic chondrodysplasia punctata, the concentration of phytanic acid was increased, whereas pristanic acid was within the control range, resulting in a low pristanic acid/phytanic acid ratio. In the blood spot from a patient with X-linked adrenoleukodystrophy, the concentrations of the acids and their ratio were normal. These findings are consistent with results for these acids in plasma from such patients. Measurement of phytanic acid and pristanic acid and their ratios in stored dried blood collected at neonatal screening can therefore be used in the diagnosis of peroxisomal disorders, especially for those cases in which, owing to early death of the patient, no other material is available for biochemical investigations.

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