Topical treatments for mild‐to‐moderate acne

2021 ◽  
Vol 185 (3) ◽  
Keyword(s):  
Topical Treatments

Topical treatments for cutaneous warts (Review)

2007 ◽  
Vol 2007 ◽  
pp. 134-136
Author(s):  
B.H. Thiers
Keyword(s):  
Topical Treatments ◽  
Cutaneous Warts

scholarly journals Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain—Narrative Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 450
Author(s):  
Magdalena Kocot-Kępska ◽  
Renata Zajączkowska ◽  
Joanna Mika ◽  
David J. Kopsky ◽  
Jerzy Wordliczek ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Pain Management ◽  
Clinical Studies ◽  
Neuronal Cells ◽  
Case Series ◽  
Narrative Review ◽  
Peripheral Sensitization ◽  
Cellular Mechanisms ◽  
Peripheral Neuropathic Pain ◽  
Topical Treatments

Neuropathic pain in humans results from an injury or disease of the somatosensory nervous system at the peripheral or central level. Despite the considerable progress in pain management methods made to date, peripheral neuropathic pain significantly impacts patients’ quality of life, as pharmacological and non-pharmacological methods often fail or induce side effects. Topical treatments are gaining popularity in the management of peripheral neuropathic pain, due to excellent safety profiles and preferences. Moreover, topical treatments applied locally may target the underlying mechanisms of peripheral sensitization and pain. Recent studies showed that peripheral sensitization results from interactions between neuronal and non-neuronal cells, with numerous signaling molecules and molecular/cellular targets involved. This narrative review discusses the molecular/cellular mechanisms of drugs available in topical formulations utilized in clinical practice and their effectiveness in clinical studies in patients with peripheral neuropathic pain. We searched PubMed for papers published from 1 January 1995 to 30 November 2020. The key search phrases for identifying potentially relevant articles were “topical AND pain”, “topical AND neuropathic”, “topical AND treatment”, “topical AND mechanism”, “peripheral neuropathic”, and “mechanism”. The result of our search was 23 randomized controlled trials (RCT), 9 open-label studies, 16 retrospective studies, 20 case (series) reports, 8 systematic reviews, 66 narrative reviews, and 140 experimental studies. The data from preclinical studies revealed that active compounds of topical treatments exert multiple mechanisms of action, directly or indirectly modulating ion channels, receptors, proteins, and enzymes expressed by neuronal and non-neuronal cells, and thus contributing to antinociception. However, which mechanisms and the extent to which the mechanisms contribute to pain relief observed in humans remain unclear. The evidence from RCTs and reviews supports 5% lidocaine patches, 8% capsaicin patches, and botulinum toxin A injections as effective treatments in patients with peripheral neuropathic pain. In turn, single RCTs support evidence of doxepin, funapide, diclofenac, baclofen, clonidine, loperamide, and cannabidiol in neuropathic pain states. Topical administration of phenytoin, ambroxol, and prazosin is supported by observational clinical studies. For topical amitriptyline, menthol, and gabapentin, evidence comes from case reports and case series. For topical ketamine and baclofen, data supporting their effectiveness are provided by both single RCTs and case series. The discussed data from clinical studies and observations support the usefulness of topical treatments in neuropathic pain management. This review may help clinicians in making decisions regarding whether and which topical treatment may be a beneficial option, particularly in frail patients not tolerating systemic pharmacotherapy.

scholarly journals Tolerability of and Adherence to Topical Treatments in Atopic Dermatitis: A Narrative Review

2021 ◽  
Vol 11 (2) ◽  
pp. 415-431
Author(s):  
Heather L. Tier ◽  
Esther A. Balogh ◽  
Arjun M. Bashyam ◽  
Alan B. Fleischer ◽  
Jonathan M. Spergel ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Narrative Review ◽  
Topical Treatments

Topical treatments and skin-resurfacing techniques for skin ageing

2021 ◽  
Vol 2021 (8) ◽  
Author(s):  
Wei Qiang Chng ◽  
Miny Samuel ◽  
Khimara Naidoo ◽  
Huma Jaffar ◽  
Ing Wei Khor ◽  
...  
Keyword(s):  
Skin Resurfacing ◽  
Topical Treatments

scholarly journals Skin Matters: A Review of Topical Treatments for Chronic Pain. Part One: Skin Physiology and Delivery Systems

2015 ◽  
Vol 4 (1) ◽  
pp. 17-32 ◽  
Author(s):  
John F. Peppin ◽  
Phillip J. Albrecht ◽  
Charles Argoff ◽  
Burkhard Gustorff ◽  
Marco Pappagallo ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Delivery Systems ◽  
Skin Physiology ◽  
Topical Treatments

scholarly journals Topical Treatments for Hydrofluoric Acid Burns: A Blind Controlled Experimental Study

2003 ◽  
Vol 41 (7) ◽  
pp. 1031-1032 ◽  
Author(s):  
Alan H. Hall ◽  
Joël Blomet ◽  
Laurence Mathieu
Keyword(s):  
Experimental Study ◽  
Hydrofluoric Acid ◽  
Topical Treatments

The Chemistry of Caries Inhibition Problems and Challenges in Topical Treatments

1967 ◽  
Vol 46 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Finn Brudevold ◽  
Harold G. McCann ◽  
Rolf Nilsson ◽  
Basil Richardson ◽  
Vera Coklica
Keyword(s):  
Topical Treatments

Patients' educational needs about topical treatments for psoriasis

2013 ◽  
Vol 68 (6) ◽  
pp. e163-e168 ◽  
Author(s):  
Sabrina L. Martin ◽  
Suzanne T. McGoey ◽  
Bruce F. Bebo ◽  
Steven R. Feldman
Keyword(s):  
Educational Needs ◽  
Topical Treatments

Therapies for Onychomycosis

2015 ◽  
Vol 105 (4) ◽  
pp. 357-366 ◽  
Author(s):  
Aditya K. Gupta ◽  
Deanne Daigle ◽  
Maryse Paquet
Keyword(s):  
Systematic Review ◽  
Clinical Practice ◽  
Treatment Efficacy ◽  
Meta Analysis ◽  
Pulse Therapy ◽  
Controlled Trials ◽  
Review Of The Literature ◽  
Mycological Cure ◽  
Randomized Controlled ◽  
Topical Treatments

New therapies for onychomycosis continue to be developed, yet treatments are seldom directly compared in randomized controlled trials. The objective of this study was to compare the rates of mycological cure for oral and topical onychomycosis treatments using network meta-analysis. A systematic review of the literature on onychomycosis treatments published before March 25, 2013, was performed, and data were analyzed using network meta-analysis. Terbinafine, 250 mg, therapy was significantly superior to all treatments except itraconazole, 400 mg, pulse therapy; itraconazole, 200 mg, therapy was significantly superior to fluconazole and the topical treatments; and fluconazole, efinaconazole, ciclopirox, terbinafine nail solution, and amorolfine treatments were significantly superior to only placebo. These results support the superiority of 12-week continuous terbinafine, 250 mg, therapy and itraconazole, 400 mg, pulse therapy (1 week per month for 3 months) while suggesting the equivalence of topical therapies. These results reflect findings from the literature and treatment efficacy observed in clinical practice.

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