scholarly journals Ebselen reduces cigarette smoke‐induced vascular endothelial dysfunction in mice

2021 ◽  
Author(s):  
Kurt Brassington ◽  
Stanley M.H. Chan ◽  
Huei Jiunn Seow ◽  
Aleksandar Dobric ◽  
Steven Bozinovski ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cigarette Smoke ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction

scholarly journals Piper sarmentosum Roxb. Attenuates Vascular Endothelial Dysfunction in Nicotine-Induced Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Muhd Fakh Rur Razi Md. Salleh ◽  
Amilia Aminuddin ◽  
Adila A. Hamid ◽  
Norizam Salamt ◽  
Fadhlullah Zuhair Japar Sidik ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cigarette Smoke ◽  
Vascular Dysfunction ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Vascular Endothelial Dysfunction ◽  
Sprague Dawley ◽  
Oral Gavage ◽  
Nicotine Administration ◽  
Sprague Dawley Rats

Exposure to cigarette smoke is an important risk factor for cardiovascular diseases. Nicotine is an addictive compound in cigarette smoke that triggers oxidative stress, which leads to vascular dysfunction. Piper sarmentosum Roxb. is a herb with antioxidant and vascular protective effects. This study evaluated the potential protective effect of the aqueous extract of P. sarmentosum leaf (AEPS) on vascular dysfunction in rats induced with prolonged nicotine administration. A total of 22 male Sprague-Dawley rats were divided into control (normal saline, oral gavage [p.o.]), nicotine (0.8 mg/kg/day nicotine, intraperitoneally [i.p.]), and nicotine + AEPS groups (250 mg/kg/day AEPS, p.o. + 0.8 mg/kg/day nicotine, i.p.). Treatment was given for 21 days. Thoracic aortae were harvested from the rats for the measurement of vasorelaxation, vascular nitric oxide (NO) level, and antioxidant level and the assessment of vascular remodeling. Rats treated with AEPS had improved vasorelaxation to endothelium-dependent vasodilator, acetylcholine (ACh), compared with the nicotine-induced rats (p < 0.05). The presence of endothelium increased the maximum relaxation of aortic rings in response to ACh. Compared with the nicotine group, AEPS enhanced vascular NO level (p < 0.001) and increased antioxidant levels as measured by superoxide dismutase activity (p < 0.05), catalase activity (p < 0.01), and reduced glutathione level (p < 0.05). No remarkable changes in aortic histomorphometry were detected. In conclusion, P. sarmentosum attenuates vascular endothelial dysfunction in nicotine-induced rats by improving vasorelaxation and enhancing vascular NO and antioxidant levels.

scholarly journals Ebselen reduces cigarette smoke-induced vascular endothelial dysfunction in mice

2020 ◽  
Author(s):  
Kurt Brassington ◽  
Stanley Chan ◽  
Huei Seow ◽  
Aleksandar Dobric ◽  
Steven Bozinovski ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cigarette Smoke ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction

Hsa_circ_0008360 sponges miR-186-5p to target CCND2 to modulate high glucose-induced vascular endothelial dysfunction

Cell Cycle ◽  
2021 ◽  
pp. 1-13
Author(s):  
Qian-Qian Zhu ◽  
Xi-Bin Pu ◽  
Tian-Chi Chen ◽  
Chen-Yang Qiu ◽  
Zi-Heng Wu ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
High Glucose ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction

Peroxynitrite and Vascular Endothelial Dysfunction in Diabetes Mellitus

Endothelium ◽  
2004 ◽  
Vol 11 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Ming-Hui Zou ◽  
Richard A. Cohen ◽  
Volker Ullrich
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction

scholarly journals Vascular endothelial dysfunction in Duchenne muscular dystrophy is restored by bradykinin through upregulation of eNOS and nNOS

2011 ◽  
Vol 107 (1) ◽  
Author(s):  
Hubert Dabiré ◽  
Inès Barthélémy ◽  
Nicolas Blanchard-Gutton ◽  
Lucien Sambin ◽  
Carolina Carlos Sampedrano ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Endothelial Dysfunction ◽  
Muscular Dystrophy ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction

Vascular endothelial dysfunction in cirrhosis

2007 ◽  
Vol 46 (5) ◽  
pp. 927-934 ◽  
Author(s):  
Yasuko Iwakiri ◽  
Roberto J. Groszmann
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction
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