scholarly journals Dynamics of circulating dendritic cells and cytokines after kidney transplantation—No effect of remote ischaemic conditioning

2021 ◽  
Author(s):  
Marie B. Nielsen ◽  
Kristian Ravlo ◽  
Marco Eijken ◽  
Nicoline V. Krogstrup ◽  
Morten Bue Svendsen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Kidney Transplantation ◽  
Remote Ischaemic Conditioning ◽  
Ischaemic Conditioning

scholarly journals Improved GFR and renal plasma perfusion following remote ischaemic conditioning in a porcine kidney transplantation model

2012 ◽  
Vol 25 (9) ◽  
pp. 1002-1012 ◽  
Author(s):  
Peter Soendergaard ◽  
Nicoline V. Krogstrup ◽  
Niels G. Secher ◽  
Kristian Ravlo ◽  
Anna K. Keller ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Porcine Kidney ◽  
Remote Ischaemic Conditioning ◽  
Transplantation Model ◽  
Ischaemic Conditioning

No effect of remote ischaemic conditioning on inflammation in a porcine kidney transplantation model

2014 ◽  
Vol 31 (2) ◽  
pp. 98-104 ◽  
Author(s):  
Niels Secher ◽  
Peter Soendergaard ◽  
Kristian Ravlo ◽  
Christoffer Soelling ◽  
Asger Granfeldt ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Porcine Kidney ◽  
Remote Ischaemic Conditioning ◽  
Transplantation Model ◽  
Ischaemic Conditioning

9 Importance of intrinsic cardiac nerves in both direct and remote ischaemic conditioning

Heart ◽  
2015 ◽  
Vol 101 (Suppl 6) ◽  
pp. A3.3-A3
Author(s):  
JMJ Pickard ◽  
SM Davidson ◽  
DM Yellon
Keyword(s):  
Remote Ischaemic Conditioning ◽  
Ischaemic Conditioning ◽  
Intrinsic Cardiac Nerves ◽  
Cardiac Nerves

scholarly journals Daily remote ischaemic conditioning following acute myocardial infarction: a randomised controlled trial

Heart ◽  
2018 ◽  
Vol 104 (23) ◽  
pp. 1955-1962 ◽  
Author(s):  
Andrew Peter Vanezis ◽  
Jayanth Ranjit Arnold ◽  
Glenn Rodrigo ◽  
Florence Y Lai ◽  
Radek Debiec ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Secondary Outcome ◽  
Control Groups ◽  
Acute Ischaemia ◽  
Ventricular Ejection Fraction ◽  
Remote Ischaemic Conditioning ◽  
And Control ◽  
Ischaemic Conditioning

BackgroundRemote ischaemic conditioning (rIC) is a cardioprotective tool which has shown promise in preclinical and clinical trials in the context of acute ischaemia. Repeated rIC post myocardial infarction may provide additional benefits which have not previously been tested clinically.MethodsThe trial assessed the role of daily rIC in enhancing left ventricular ejection fraction (LVEF) recovery in patients with impaired LVEF (<45%) after ST segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (P-PCI). Patients were recruited from four UK hospitals and randomised to receive either 4 weeks of daily rIC or sham conditioning using the autoRIC Device (CellAegis) starting on day 3 post P-PCI. The primary endpoint was the improvement in LVEF over 4 months assessed by cardiac MRI (CMR). Seventy-three patients (38 cases, 35 controls) completed the study.ResultsThe treatment and control groups were well matched at baseline including for mean LVEF (42.8% vs 44.3% respectively, p=0.952). There was no difference in the improvement in LVEF over 4 months between the treatment and control groups (4.8%±7.8% vs 4.6%±5.9% respectively, p=0.924). No differences were seen in the secondary outcome measures including changes in infarct size and left ventricular end-diastolic and systolic volumes, major adverse cardiac and cerebral event, mean Kansas City Cardiomyopathy Questionnaire score and change in N-terminal pro-brain natriuretic peptide levels.ConclusionsDaily rIC starting on day 3 and continued for 4 weeks following successful P-PCI for STEMI did not improve LVEF as assessed by CMR after 4 months when compared with a matched control group.Trial registration numberNCT0166461.

Remote ischaemic conditioning in ST elevation myocardial infarction: a registry-based randomised trial

Heart ◽  
2021 ◽  
pp. heartjnl-2021-319455
Author(s):  
Kevin R Bainey ◽  
Yinggan Zheng ◽  
Richard Coulden ◽  
Emer Sonnex ◽  
Richard Thompson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Myocardial Perfusion ◽  
Clinical Outcomes ◽  
St Elevation Myocardial Infarction ◽  
Volume Index ◽  
Cardiovascular Mri ◽  
Randomised Study ◽  
Remote Ischaemic Conditioning ◽  
St Elevation ◽  
Ischaemic Conditioning

ObjectivesRemote ischaemic conditioning (RIC) has been tested as a possible strategy for mitigating reperfusion injury in ST elevation myocardial infarction (STEMI) with primary percutaneous coronary intervention (PPCI). However, surrogate outcomes have shown inconsistent effects with lack of clinical correlation.MethodsWe performed a registry-based randomised study of patients with STEMI allocated to RIC (4 cycles of blood pressure cuff inflation to 200 mm Hg for 5 min of ischaemia followed by 5 min of reperfusion) or standard of care (SOC) during PPCI. We examined the associations of RIC on core laboratory measurements of myocardial perfusion, infarct size (IS), left ventricular (LV) performance and clinical outcomes.ResultsA total of 252 patients were enrolled. The median age was 61 (IQR: 55–70) years and 72.8% were male. Sum ST segment deviation resolution ≥50% was similar between RIC and SOC (65.2% vs 55.7%, p=0.269). In those with 3-day cardiovascular MRI (n=88), no difference in median (25th, 75th percentiles) IS (14.9% (4.5%, 23.1%) vs 16.1% (3.3%, 22.0%), p=0.980), LV dimensions (LV end-diastolic volume index: 78.7 (71.1, 91.2) mL/m2 vs 79.9 (71.2, 88.8) mL/m2, p=0.630; LV end-systolic volume index: 48.8 (35.7, 51.4) mL/m2 vs 37.9 (31.8, 47.5) mL/m2, p=0.551) or ejection fraction (50.0% (41.0%–55.0%) vs 50.0% (43.0%–56.0%), p=0.554) was demonstrated. Similar results were observed with 90-day cardiovascular MRI. At 1 year, the clinical composite of death, congestive heart failure, cardiogenic shock and recurrent myocardial infarction was similar in RIC and SOC (21.7% vs 13.3%, p=0.110).ConclusionsIn a contemporary registry-based randomised study of patients with STEMI undergoing PPCI, adjunctive therapy with RIC did not improve myocardial perfusion, reduce IS or alter LV performance. Consequently, there was no difference in clinical outcomes within 1 year.Trial registration numberNCT03930589.

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