Impaired quality of life in patients with treated acromegaly despite long-term biochemically stable disease: Results from a 5-years prospective study

2017 ◽  
Vol 86 (6) ◽  
pp. 806-815 ◽  
Author(s):  
Nikolaos Kyriakakis ◽  
Julie Lynch ◽  
Stephen G. Gilbey ◽  
Susan M. Webb ◽  
Robert D. Murray
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
Stable Disease ◽  
Impaired Quality

scholarly journals Physical Activity and Long-term Quality of Life among Colorectal Cancer Survivors—A Population-based Prospective Study

2020 ◽  
Vol 13 (7) ◽  
pp. 611-622
Author(s):  
Ruth Elisa Eyl ◽  
Lena Koch-Gallenkamp ◽  
Lina Jansen ◽  
Viola Walter ◽  
Prudence R. Carr ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Colorectal Cancer ◽  
Prospective Study ◽  
Cancer Survivors ◽  
Population Based ◽  
Colorectal Cancer Survivors

scholarly journals Long-Term Response after 94 Cycles of Trabectedin in a Patient with Metastatic Leiomyosarcoma of the Lower Extremity

2020 ◽  
Vol 13 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Magda Cordeiro ◽  
José Manuel Casanova ◽  
Joana Rodrigues ◽  
João Freitas ◽  
Ruben Fonseca ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Soft Tissue ◽  
Lower Extremity ◽  
Disease Progression ◽  
Stable Disease ◽  
Case Reports ◽  
Soft Tissue Sarcomas ◽  
Term Therapy

Leiomyosarcomas of the lower extremity are extremely rare disorders and account for 10–15% of limb soft tissue sarcomas. These tumours have poor prognosis and even in early stages, patients persist at high risk for local and distant relapse; consequently, the treatment of advanced leiomyosarcoma of the lower extremity embodies a substantial defy. We present the case of a 73-year-old man diagnosed with metastatic lower extremity leiomyosarcoma of the hallux soft tissue, and with bone, lung and lymph node metastasis. After core needle biopsy confirmation of high-grade fusocellular sarcoma, the patient underwent surgery of the primary tumour and received anthracycline-based chemotherapy. However, after a 7-month progression-free survival period, a CT revealed lung disease progression. Sequentially, the patient was treated with trabectedin (Yondelis®) at a dose of 1.5 mg/m2 resulting in complete remission of the lung metastasis and stable disease of the remaining lesions after 26 months of treatment. Afterwards, the patient started on maintenance therapy with trabectedin, resulting in long-lasting stable disease, as he was able to receive 94 cycles with very acceptable quality of life. Finally, in March 2019, the patient died of community-acquired pneumonia without objective progression disease. This clinical case reports the first patient ever treated with 94 cycles of trabectedin. Our results additionally confirm that trabectedin wields relevant oncostatic benefits with a manageable safety profile and without cumulative toxicities. Trabectedin properties enable a maintenance long-term therapy (until disease progression or unbearable toxicity), with a high impact on survival and with a preserved quality of life.

scholarly journals Long-term quality of life in cervical dystonia after treatment with abobotulinum toxin A: a 2-year prospective study

2018 ◽  
Vol Volume 14 ◽  
pp. 1119-1124 ◽  
Author(s):  
Subsai Kongsaengdao ◽  
Narong Maneeton ◽  
Benchalak Maneeton
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
Cervical Dystonia ◽  
Toxin A

scholarly journals Predictors of Long-term Quality of Life in Women with Breast Cancer: A Prospective Study

2017 ◽  
Vol 99 (2) ◽  
pp. E545
Author(s):  
N.N. Sanford ◽  
M.N. Swaroop ◽  
L.W. Salama ◽  
A. Mina ◽  
K.L. Mirabeau-Beale ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Prospective Study ◽  
A Prospective Study

scholarly journals “You’re only a carrier” – women and the language of haemophilia

2021 ◽  
Vol 8 (1) ◽  
pp. 128-132
Author(s):  
Steve Chaplin ◽  
Kate Khair
Keyword(s):  
Quality Of Life ◽  
Factor Viii ◽  
Strong Evidence ◽  
18Th Century ◽  
Joint Damage ◽  
Gene Variant ◽  
Factor Viii Activity ◽  
Impaired Quality

Abstract Women who have the gene variant for haemophilia are labelled solely as ‘carriers’ unless they have a factor VIII activity of ≤40%. This term, which describes an individual who can pass on a disorder but are themselves unaffected, reflects a legacy that extends from the 18th century to the present day. There is strong evidence that women labelled as carriers experience heavy periods, joint damage, pain and impaired quality of life. The label ‘carrier’ does not recognise this burden and is associated with guilt, stigma and difficulty accessing care. People living with a long-term disorder should now be described using person-first terminology and it is common to see the term ‘people with haemophilia’. The term ‘carrier’ should be limited to its application in genetics and not used as a catch-all label for women with haemophilia.

scholarly journals Problems of Diagnosis, Conservative Treatment and Long-Term Results of “Mallet Finger” Fracture

2021 ◽  
pp. 42-50
Author(s):  
A.A. Bezuhlyi ◽  
A.S. Lysak
Keyword(s):  
Quality Of Life ◽  
Upper Extremity ◽  
Distal Phalanx ◽  
Diagnosis And Treatment ◽  
Long Term Results ◽  
Mallet Finger ◽  
Dorsal Edge ◽  
Impaired Quality

Summary. Distal phalanx dorsal edge fracture is treated in a relatively simple closed manner during the first weeks after injury. The role of the distal interphalangeal joint in the upper extremity integral function reaches conventionally only a few percent. This may lead to insufficient attention and a large number of mistakes in diagnosis and treatment of such injuries, which in turn provokes complications that are much more difficult to treat than the primary injury. This article considers the most common problems of diagnosis and treatment of “mallet finger” fractures. Advantages and disadvantages of various techniques used in the treatment of such fractures in acute and neglected cases are considered and analyzed. Objective: to study the effect of distal phalanx dorsal edge avulsive fractures on function of the upper limb, quality of life, and depression rate in long term period after injury. Materials and Methods. Data from 11 patients (8 (88%) males and 3 (12%) females) with neglected cases of distal phalanx dorsal edge avulsive fractures were studied. QuickDASH questionnaire and visual analog scales were used to study impaired quality of life and depression rate in such patients. Indicators that lead to the need for surgery in long term period after injury have been identified. Results. It was determined that in long term period, in patients with a “mallet finger” fracture, function of the upper extremity suffered significantly and was 29.2±20.2 points (range 2.3-75) according to QuickDASH scale. This condition also significantly affected the general well-being of the patient. Average value of impaired quality of life was 43.6±24.6 (range 0-90 points), and depression rate due to upper extremity dysfunction was 44.6±22.7 (range 0-90 points). Conclusions. Despite the relatively minor injury, high rates of dysfunction, impact on quality of life and depression rate indicate the need to restore finger function even in long term period after injury.

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