Single‐staged implant placement using the bone ring technique with and without membrane placement: Micro‐CT analysis in a preclinical in vivo study

ABSTRACT Objectives: The aim of this in vivo study was to investigate the preventive effect of two different adhesives on enamel demineralization and compare these adhesives with a conventional one. Materials and Methods: Fifteen patients requiring the extraction of their first four premolars for orthodontic treatment were included in the study. One premolar was randomly selected, and an antibacterial monomer-containing and fluoride-releasing adhesive (Clearfil Protect Bond, Kuraray Medical, Okayama, Japan) was used for orthodontic bracket bonding. Another premolar was randomly selected, and a fluoride-releasing and recharging orthodontic adhesive (Opal Seal, Ultradent Products, South Jordan, Utah) was used. One premolar was assigned as a control, and a conventional adhesive (Transbond XT, 3M Unitek, Monrovia, Calif) was used. The teeth were extracted after 8 weeks, and the demineralization areas of the 45 extracted teeth were analyzed using microcomputed tomography with software. Results: There was no significant difference between the white spot lesion (WSL) rates of the adhesives (P > .05). The volumes of the WSLs varied from 0 to 0.019349 mm3. Although Opal Seal showed the smallest lesion volumes, there was no significant difference in volumetric measurements of the lesions among the groups (P > .05). Conclusions: The findings indicated no significant differences between the preventive effects of the adhesives used in this in vivo study over 8 weeks.

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Effectiveness of Antianxiety Drugs on Postoperative Pain Perception After Implant Placement: An In Vivo Study

Journal of Advanced Oral Research ◽

10.1177/2320206820981485 ◽

2021 ◽

Vol 12 (1) ◽

pp. 144-152

Author(s):

Minal Gopal Tulsani ◽

Dhanraj Ganapathy ◽

Divya Rupawat ◽

Sanjana Devi

Keyword(s):

Postoperative Pain ◽

Analysis Of Variance ◽

Pain Perception ◽

Anxiety Level ◽

In Vivo Study ◽

Implant Placement ◽

Significant Difference ◽

Group A ◽

Group B

Aim: To evaluate the effectiveness of midazolam and zolpidem on postoperative pain perception in patients undergoing implant placement. Materials and Methods: In the present in vivo study 60 patients undergoing implant placement were selected based on the inclusion criteria framed and were randomly allocated using sequentially numbered, opaque, and sealed envelope (SNOSE) method into 3 groups with 20 patients each after obtaining informed consent. Group A was the control group, Group B received midazolam 7.5 mg 30 minutes before the procedure. Group C received zolpidem 5 mg 30 minutes before the procedure. The anxiety level of patients was recorded using the Corah scale and postoperative pain was recorded after 2 hours of implant placement using the VAS scale. Statistical analysis was done using analysis of variance (ANOVA), one-way multivariate analysis of variance (one-way MANOVA), and then Tukey’s Honestly Significant Difference (HSD) test for comparison among groups at the 0.05 level of significance. Results: Group A had a mean anxiety level of 16 ± 1.451, Group B had a mean anxiety level of 11.2 ± 2.858, and Group C had a mean anxiety level of 13 ± 2.9019 and a statistically significant difference between the groups was observed ( P < .05). The mean for the postoperative pain perception for Group A was 6.8 ± 1.1965, for Group B was 3.8 ± 1.3611, and Group C was 5 ± 1.451 and a statistically significant difference between the groups was observed ( P < .05). Conclusion: This study concluded that both midazolam and zolpidem significantly reduced anxiety levels and postoperative pain in patients undergoing implant placement.

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In Vitro and In Vivo Study of Titanium Grade IV and Titanium Grade V Implants with Different Surface Treatments

Metals ◽

10.3390/met10040449 ◽

2020 ◽

Vol 10 (4) ◽

pp. 449 ◽

Cited By ~ 2

Author(s):

Rosa-Maria Diaz-Sanchez ◽

Alvaro de-Paz-Carrion ◽

Maria-Angeles Serrera-Figallo ◽

Daniel Torres-Lagares ◽

Angel Barranco ◽

...

Keyword(s):

Cell Proliferation ◽

Histological Study ◽

Surface Treatments ◽

In Vivo Study ◽

Positive Trend ◽

Similar Response ◽

Micro Ct ◽

Titanium Grade

The aim of our study is to evaluate different implant surface treatments using TiIV and TiV in in vitro and in vivo studies. An in vitro study was established comprising four study groups with treated and untreated TiIV titanium discs (TiIVT and TiIVNT) and treated and untreated TiV titanium discs (TiVT and TiVNT). The surface treatment consisted in a grit blasting treatment with alumina and double acid passivation to modify surface roughness. The surface chemical composition and the surface microstructure of the samples were analyzed. The titanium discs were subjected to cell cultures to determine cell adhesion and proliferation of osteoblasts on them. The in vivo study was carried out on the tibia of three New Zealand rabbits in which 18 implants divided into three experimental groups were placed (TiIVT, TiIVNT, and TiVT). Micro-computed tomography (micro-CT) was performed to determine bone density around the implants. The results showed that cell culture had minor adhesion and cell proliferation in TiIVT and TiVT within the first 6 and 24 h. However, no differences were found after 48 h. No statistically significant differences were found in the in vivo micro-CT and histological study; however, there was a positive trend in bone formation in the groups with a treated surface. Conclusions: All groups showed a similar response to in vitro cell proliferation cultures after 48 h. No statistically significant differences were found in the in vivo micro-CT and histological study.

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Strontium Incorporated Coralline Hydroxyapatite for Engineering Bone

ISRN Biomaterials ◽

10.5402/2013/649163 ◽

2013 ◽

Vol 2013 ◽

pp. 1-11 ◽

Cited By ~ 6

Author(s):

Waiching Liu ◽

Ting Wang ◽

Yuhui Shen ◽

Haobo Pan ◽

Songlin Peng ◽

...

Keyword(s):

Bone Resorption ◽

Rat Model ◽

Bone Growth ◽

Micro Ct ◽

Coralline Hydroxyapatite ◽

Ct Analysis ◽

Surface Morphologies ◽

Volume Retention

Goniopora was hydrothermally converted to coralline hydroxyapatite (CHA) and incorporated with Sr (Sr-CHA). The pore size of Goniopora was in the range of 40–300 μm with a porosity of about 68%. Surface morphologies of the coral were modified to flake-like hydroxyapatite structures on CHA and the addition of Sr detected on Sr-CHA as confirmed by SEM and EDX. As the first report of incorporating Sr into coral, about 6%–14% Sr was detected on Sr-CHA. The compressive strengths of CHA and Sr-CHA were not compromised due to the hydrothermal treatments. Sr-CHA was studied in vitro using MC3T3-E1 cells and in vivo with an ovariectomized rat model. The proliferation of MC3T3-E1 cells was significantly promoted by Sr-CHA as compared to CHA. Moreover, higher scaffold volume retention (+40%) was reported on the micro-CT analysis of the Sr-CHA scaffold. The results suggest that the incorporation of Sr in CHA can further enhance the osteoconductivity and osteoinductivity of corals. Strontium has been suggested to stimulate bone growth and inhibit bone resorption. In this study, we have successfully incorporated Sr into CHA with the natural porous structure remained and explored the idea of Sr-CHA as a potential scaffolding material for bone regeneration.

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