First Asian Kidney Donor Profile Index (KDPI) and Estimated Post‐Transplant Survival (EPTS) Models, With Validation Against US Models in Thai Population

2021 ◽  
Author(s):  
Nuttasith Larpparisuth ◽  
Supanit Nivatvongs ◽  
Atiporn Ingsathit ◽  
Kajohnsak Noppakun ◽  
Adisorn Lumpaopong ◽  
...  
Keyword(s):  
Kidney Donor ◽  
Thai Population ◽  
Transplant Survival ◽  
Post Transplant

scholarly journals Regional Disparities in Transplantation With Deceased Donor Kidneys With Kidney Donor Profile Index Less Than 20% Among Candidates With Top 20% Estimated Post Transplant Survival

2019 ◽  
Vol 29 (4) ◽  
pp. 354-360 ◽  
Author(s):  
S. Ali Husain ◽  
Kristen L. King ◽  
Geoffrey K. Dube ◽  
Demetra Tsapepas ◽  
David J. Cohen ◽  
...  
Keyword(s):  
United States ◽  
Research Question ◽  
Deceased Donor ◽  
The United States ◽  
Strongly Correlated ◽  
Kidney Donor ◽  
Donor Kidney ◽  
Transplant Survival ◽  
Post Transplant ◽  
Deceased Donor Kidney

Introduction: The Kidney Allocation System in the United States prioritizes candidates with Estimated Post-Transplant Survival (EPTS) ≤20% to receive deceased donor kidneys with Kidney Donor Profile Index (KDPI) ≤20%. Research Question: We compared access to KDPI ≤ 20% kidneys for EPTS ≤ 20% candidates across the United States to determine whether geographic disparities in access to these low KDPI kidneys exist. Design: We identified all incident adult deceased donor kidney candidates wait-listed January 1, 2015, to March 31, 2018, using United Network for Organ Sharing data. We calculated the proportion of candidates transplanted, final EPTS, and KDPI of transplanted kidneys for candidates listed with EPTS ≤ 20% versus >20%. We compared the odds of receiving a KDPI ≤ 20% deceased donor kidney for EPTS ≤ 20% candidates across regions using logistic regression. Results: Among 121 069 deceased donor kidney candidates, 28.5% had listing EPTS ≤ 20%. Of these, 16.1% received deceased donor kidney transplants (candidates listed EPTS > 20%: 17.1% transplanted) and 12.3% lost EPTS ≤ 20% status. Only 49.4% of transplanted EPTS ≤ 20% candidates received a KDPI ≤ 20% kidney, and 48.3% of KDPI ≤ 20% kidneys went to recipients with EPTS > 20% at the time of transplantation. Odds of receiving a KDPI ≤ 20% kidney were highest in region 6 and lowest in region 9 (odds ratio 0.19 [0.13 to 0.28]). The ratio of KDPI ≤ 20% donors per EPTS ≤ 20% candidate and likelihood of KDPI ≤ 20% transplantation were strongly correlated ( r 2 = 0.84). Discussion: Marked geographic variation in the likelihood of receiving a KDPI ≤ 20% deceased donor kidney among transplanted EPTS ≤ 20% candidates exists and is related to differences in organ availability within allocation borders. Policy changes to improve organ sharing are needed to improve equity in access to low KDPI kidneys.

scholarly journals The Sum of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scale and Their Correlation with eGFR Decline in Deceased Donor Kidney Recipients

2021 ◽  
Author(s):  
Pablo Maggiani-Aguilera ◽  
Sergio Hernández-Estrada ◽  
José H. Cano-Cervantes ◽  
Jonathan S. Chávez-Iñiguez ◽  
Christian Pérez-Flores ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Kidney Donor ◽  
Donor Kidney ◽  
Transplant Survival ◽  
Post Transplant ◽  
Kidney Recipients ◽  
Deceased Donor Kidney ◽  
Egfr Decline

Clinical stabilization of ACLF patients before orthotopic liver transplantation predicts post-transplant survival

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
P Huebener ◽  
M Sterneck ◽  
K Bangert ◽  
A Lohse ◽  
S Kluge ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Transplant Survival ◽  
Post Transplant ◽  
Clinical Stabilization

scholarly journals Suppressing Pyroptosis Augments Post-Transplant Survival of Stem Cells and Cardiac Function Following Ischemic Injury

2021 ◽  
Vol 22 (15) ◽  
pp. 7946
Author(s):  
Chang Youn Lee ◽  
Seahyoung Lee ◽  
Seongtae Jeong ◽  
Jiyun Lee ◽  
Hyang-Hee Seo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Stem Cell ◽  
Cardiac Fibrosis ◽  
Ischemia Reperfusion ◽  
Cardiac Cells ◽  
Transplant Survival ◽  
Post Transplant ◽  
Heart Functions ◽  
Cell Death Mechanisms

The acute demise of stem cells following transplantation significantly compromises the efficacy of stem cell-based cell therapeutics for infarcted hearts. As the stem cells transplanted into the damaged heart are readily exposed to the hostile environment, it can be assumed that the acute death of the transplanted stem cells is also inflicted by the same environmental cues that caused massive death of the host cardiac cells. Pyroptosis, a highly inflammatory form of programmed cell death, has been added to the list of important cell death mechanisms in the damaged heart. However, unlike the well-established cell death mechanisms such as necrosis or apoptosis, the exact role and significance of pyroptosis in the acute death of transplanted stem cells have not been explored in depth. In the present study, we found that M1 macrophages mediate the pyroptosis in the ischemia/reperfusion (I/R) injured hearts and identified miRNA-762 as an important regulator of interleukin 1b production and subsequent pyroptosis. Delivery of exogenous miRNA-762 prior to transplantation significantly increased the post-transplant survival of stem cells and also significantly ameliorated cardiac fibrosis and heart functions following I/R injury. Our data strongly suggest that suppressing pyroptosis can be an effective adjuvant strategy to enhance the efficacy of stem cell-based therapeutics for diseased hearts.

scholarly journals Repetitive pruning of Serianthes nursery plants improves transplant quality and post-transplant survival

2019 ◽  
Vol 14 (8) ◽  
pp. 1621246 ◽  
Author(s):  
Thomas E. Marler
Keyword(s):  
Transplant Survival ◽  
Post Transplant

The combination of acute-on-chronic liver failure (ACLF) as defined by EASL-CLIF consortium definition and MELD can predict post-transplant survival in patients with ACLF

2018 ◽  
Vol 68 ◽  
pp. S250
Author(s):  
U. Agbim ◽  
A. Sharma ◽  
S. Karri ◽  
J. Vanatta ◽  
H. Gonzalez ◽  
...  
Keyword(s):  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Transplant Survival ◽  
Post Transplant

Is MELD score sufficient to predict not only death on waiting list, but also post-transplant survival?

2006 ◽  
Vol 19 (4) ◽  
pp. 275-281 ◽  
Author(s):  
Gerd R. Silberhumer ◽  
Hubert Hetz ◽  
Susanne Rasoul-Rockenschaub ◽  
Markus Peck-Radosavljevic ◽  
Thomas Soliman ◽  
...  
Keyword(s):  
Meld Score ◽  
Waiting List ◽  
Transplant Survival ◽  
Post Transplant
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