Relationship between blood glucose variability in ambulatory glucose profile and standardized continuous glucose monitoring metrics: Subanalysis of a prospective cohort study

2021 ◽  
Author(s):  
Akemi Tokutsu ◽  
Yosuke Okada ◽  
Tomoya Mita ◽  
Keiichi Torimoto ◽  
Satomi Wakasugi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Blood Glucose ◽  
Prospective Cohort Study ◽  
Continuous Glucose Monitoring ◽  
Prospective Cohort ◽  
Glucose Monitoring ◽  
Glucose Variability ◽  
Glucose Profile ◽  
Blood Glucose Variability

scholarly journals Relationship Between Blood Glucose Variability in Ambulatory Glucose Profile and Standardized Continuous Glucose Monitoring Metrics; A Pilot Study

2020 ◽  
Author(s):  
Akemi 09034837312 ◽  
Yosuke Okada ◽  
Keiichi Torimoto ◽  
Yoshiya Tanaka
Keyword(s):  
Blood Glucose ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Glucose Variability ◽  
Control Group ◽  
Diabetic Patients ◽  
Cutoff Value ◽  
Glucose Profile ◽  
Blood Glucose Variability ◽  
The Relationship

Abstract Background: Treatment indexes using continuous glucose monitoring (CGM) have become standardized internationally, and the use of ambulatory glucose profile (AGP) is currently recommended. However, the relationship between AGP indexes and standardized CGM metrics has not been investigated. Using flash glucose monitoring (FGM), this retrospective study served to evaluate the association of the inter-quartile range (IQR) of AGP with standardized CGM metrics.Methods: The study subjects were 30 patients with type 2 diabetes mellitus (T2DM) and 23 non-diabetic patients (control group). We evaluated average IQR (AIQR) and standardized CGM metrics. The primary endpoint was the relationship between AIQR and Time in range (TIR) in a 24-hour period.Results: In the T2DM group, the AIQR was notably high and correlated negatively with TIR, and positively with Time above range, average glucose level, SD, CV, and MODD. For the T2DM group, the AIQR was notably lower in patients who achieved TIR>70%, compared to those who did not. The AIQR cutoff value, as determined by ROC analysis, was 28.3 mg/dL for those who achieved TIR>70%. No association was detected between the presence of hypoglycemia and AIQR.Conclusions: Our study is the first to provide the AIQR cutoff value for achieving the TIR target value. The range of blood glucose variability in AGP was associated with indexes of intra- and interday variations and hyperglycemia. Our results provide new perspectives in the yet-to-be established methods for evaluation of AGP in practical clinical settings.

Daily improvement of blood glucose profile by continuous glucose monitoring (CGM)

2019 ◽  
Vol 6 (2) ◽  
pp. 24-26 ◽  
Author(s):  
Hiroshi Bando ◽  
Yoshikane Kato ◽  
Setsuko Kanazawa ◽  
Mayumi Tanaka ◽  
Etsuko Sueki ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Insulin Injection ◽  
Glucose Variability ◽  
Diabetic Control ◽  
Future Research ◽  
Glucose Profile ◽  
Insulin Glargin ◽  
Blood Glucose Profile

Background: The problem of glucose variability has been in focus for type 1 diabetes mellitus (T1DM) on insulin treatment. Daily profile of blood glucose was studied on Continuous Glucose Monitoring (CGM) using Free Style Libre. Case presentation and results: Patient is 54 year-old T1DM female, with HbA1c 7.8%. The blood glucose variability was measured by Free Style Libre. Insulin therapy included multiple daily insulin injection (MDI) of Insulin Glargin and Aspart. The result revealed unstable blood glucose profile in day 1 and 2. After that, the level and fluctuation of blood glucose gradually decreased from day 3 to 14. Average blood glucose in a day was 174mg/dL, 159mg/dL, 138mg/dL, 125mg/dL and 110mg/dL, in day 2, 4, 7, 9, 11, respectively. There was a discrepancy of HbA1c between 7.8% by laboratory measurement and 6.3% presumed value by Free Style Libre. Discussion and Conclusion: Free Style Libre showed satisfactory results as CGM. There was lower HbA1c value by presumed calculation, which would be possibly due to every 15minutes measurement and difficulty in checking abrupt glucose surges. CGM application would probably bring diabetic subjects behavioral change of life style, leading to better diabetic control. These results would become reference data in CGM study for future research.

scholarly journals Characterizing Blood Glucose Variability Using New Metrics with Continuous Glucose Monitoring Data

2011 ◽  
Vol 5 (4) ◽  
pp. 871-878 ◽  
Author(s):  
Cynthia R. Marling ◽  
Jay H. Shubrook ◽  
Stanley J. Vernier ◽  
Matthew T. Wiley ◽  
Frank L. Schwartz
Keyword(s):  
Blood Glucose ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Glucose Variability ◽  
Monitoring Data ◽  
Blood Glucose Variability

scholarly journals Validation of Continuous Glucose Monitoring in Children and Adolescents With Cystic Fibrosis: A prospective cohort study

Diabetes Care ◽  
2009 ◽  
Vol 32 (6) ◽  
pp. 1020-1022 ◽  
Author(s):  
S. M.P. O'Riordan ◽  
P. Hindmarsh ◽  
N. R. Hill ◽  
D. R. Matthews ◽  
S. George ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Cohort Study ◽  
Children And Adolescents ◽  
Prospective Cohort Study ◽  
Continuous Glucose Monitoring ◽  
Prospective Cohort ◽  
Glucose Monitoring

scholarly journals Adverse pregnancy outcomes associated with moderate elevations in blood pressure or blood glucose in Ugandan women; a prospective cohort study

2021 ◽  
Vol 1 (2) ◽  
pp. 100007
Author(s):  
Jack Milln ◽  
Betty Nakabuye ◽  
Barnabas Natamba ◽  
Isaac Sekitoleko ◽  
Michael Mubiru ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Blood Glucose ◽  
Prospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Prospective Cohort ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy

scholarly journals The Association between Fasting Blood Glucose and Liver Cancer Risk in Chinese Males: A Prospective Cohort Study

2017 ◽  
Vol 83 (1) ◽  
pp. 80
Author(s):  
X. Feng ◽  
G. Wang ◽  
Z. Lv ◽  
S. Chen ◽  
L. Wei ◽  
...  
Keyword(s):  
Cohort Study ◽  
Blood Glucose ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Fasting Blood Glucose
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