A severe adverse reaction to omalizumab therapy in chronic spontaneous urticaria

2019 ◽  
Vol 33 (1) ◽  
Author(s):  
Laura Dies ◽  
Alvise Sernicola ◽  
Francesca Magri ◽  
Camilla Chello ◽  
Giovanni Paolino ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Chronic Spontaneous Urticaria ◽  
Severe Adverse Reaction

Treatment of Heparin-Induced Thrombocytopenia

2002 ◽  
Vol 36 (3) ◽  
pp. 489-503 ◽  
Author(s):  
William E Dager ◽  
Richard H White
Keyword(s):  
Adverse Reaction ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Low Molecular Weight ◽  
National Library ◽  
Severe Adverse Reaction ◽  
Heparin Induced Thrombocytopenia ◽  
Immune Mediated ◽  
Study Selection ◽  
Clinical Conditions

OBJECTIVE: To describe heparin-induced thrombocytopenia (HIT or HIT-2), an immune-mediated adverse reaction to heparin or low-molecular-weight heparin. Available treatment options and considerations in developing a therapy approach are discussed. DATA SOURCES: A search of the National Library of Medicine (1992–June 2001) was done to identify pertinent literature. Additional references were reviewed from selected articles. STUDY SELECTION: Articles related to laboratory recognition and treatment options of HIT, including the use of agents in selected clinical conditions, were reviewed and included. CONCLUSIONS: HIT is a rare but potentially severe adverse reaction to heparin that was, until recently, poorly understood and had limited treatment options. Recent advances describing the recognition and clinical manifestations of immune-mediated HIT, including recently available antithrombotic treatment options, have dramatically changed outcomes for patients having this syndrome.

Case report: Severe adverse reaction to oral Iohexol

1991 ◽  
Vol 44 (2) ◽  
pp. 137-138 ◽  
Author(s):  
J.R. Glover ◽  
B.M. Thomas
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Severe Adverse Reaction

scholarly journals The Severe Adverse Reaction to Vitamin K1 Injection Is Anaphylactoid Reaction but Not Anaphylaxis

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90199 ◽  
Author(s):  
Yan-Ni Mi ◽  
Na-Na Ping ◽  
Xue Xiao ◽  
Yan-Bing Zhu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Anaphylactoid Reaction ◽  
Vitamin K1 ◽  
Severe Adverse Reaction

scholarly journals Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma

2018 ◽  
Vol 11 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Jorine de Haan ◽  
Johannes V. van Thienen ◽  
Michael Casaer ◽  
Rebekka A. Hannivoort ◽  
Kristel Van Calsteren ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Pregnant Woman ◽  
Metastatic Melanoma ◽  
Targeted Therapies ◽  
Adverse Reactions ◽  
Tumour Progression ◽  
Single Case ◽  
Severe Adverse Reaction ◽  
Single Case Report

Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. In patients with metastatic melanoma that wish to continue their pregnancy, targeted therapies like vemurafenib offer the only possibility of improving maternal outcome. In this article, we report on a pregnant woman with metastatic melanoma who was treated with vemurafenib during pregnancy and experienced a fatal adverse reaction.

Tocainide: A Severe Adverse Reaction

1988 ◽  
Vol 22 (2) ◽  
pp. 142-145 ◽  
Author(s):  
James M. Dunn ◽  
Paul E. Groth ◽  
Anne DeSimone
Keyword(s):  
Adverse Reaction ◽  
Short Term Memory ◽  
Memory Loss ◽  
Uneventful Recovery ◽  
Physical Status ◽  
Short Term ◽  
Severe Adverse Reaction ◽  
Premature Ventricular Contractions ◽  
Term Memory ◽  
Cardioactive Drug

Tocainide is a primary analog of lidocaine with antiarrhythmic properties used to treat ventricular rhythm disorders. A 76-year-old man with benign paroxysmal premature ventricular contractions was treated with tocainide and developed a generalized maculopapular lupoid eruption, bleeding from the lips and gingivae, vertigo, gross tremors of the extremities, fever, and short-term memory loss, which required hospitalization. The patient recovered slowly over three months with no permanent sequelae after discontinuing the drug and receiving rigorous supportive care. His excellent physical status and absence of concomitant illness contributed to an uneventful recovery. Tocainide is a potent cardioactive drug with a long biological half-life and should be used with caution.

scholarly journals Omalizumab Use in Chronic Spontaneous Urticaria during Pregnancy and a Four Years’ Follow-Up: A Case Report

2020 ◽  
Vol 12 (3) ◽  
pp. 174-177
Author(s):  
Laura Michelina Losappio ◽  
Corrado Mirone ◽  
Jan Walter Schroeder ◽  
Joseph Scibilia ◽  
Luca Balossi ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Cost Effectiveness ◽  
Skin Disorder ◽  
Therapeutic Option ◽  
Chronic Spontaneous Urticaria ◽  
Lactating Women ◽  
H1 Antihistamines ◽  
Effective Therapeutic Option

Chronic spontaneous urticaria (CSU) is a benign skin disorder usually responsive to treatment; however, at times it can be difficult to control and become very debilitating. We discuss the case of a woman with CSU that was unresponsive to H1-antihistamines who was treated with omalizumab and became pregnant during omalizumab treatment. We also considered the follow-up of the mother and newborn for 4 years after delivery. Our case report confirms that omalizumab is a safe and effective therapeutic option, after careful evaluations in terms of cost-effectiveness, in pregnant and lactating women with severe chronic urticaria. Assessment throughout follow-up confirmed a regular progression of pregnancy parameters and no adverse reaction was documented in the child from birth to 4 years of age.

Drug-induced severe adverse reaction enhanced by human herpes virus-6 reactivation

2013 ◽  
Vol 161 (5) ◽  
pp. 430-440 ◽  
Author(s):  
Manuela G. Neuman ◽  
Kristi K. McKinney ◽  
Radu M. Nanau ◽  
Vincent Kong ◽  
Izabella Malkiewicz ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Herpes Virus ◽  
Human Herpes ◽  
Severe Adverse Reaction ◽  
Drug Induced ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus
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