scholarly journals Omalizumab Use in Chronic Spontaneous Urticaria during Pregnancy and a Four Years’ Follow-Up: A Case Report

2020 ◽  
Vol 12 (3) ◽  
pp. 174-177
Author(s):  
Laura Michelina Losappio ◽  
Corrado Mirone ◽  
Jan Walter Schroeder ◽  
Joseph Scibilia ◽  
Luca Balossi ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Cost Effectiveness ◽  
Skin Disorder ◽  
Therapeutic Option ◽  
Chronic Spontaneous Urticaria ◽  
Lactating Women ◽  
H1 Antihistamines ◽  
Effective Therapeutic Option

Chronic spontaneous urticaria (CSU) is a benign skin disorder usually responsive to treatment; however, at times it can be difficult to control and become very debilitating. We discuss the case of a woman with CSU that was unresponsive to H1-antihistamines who was treated with omalizumab and became pregnant during omalizumab treatment. We also considered the follow-up of the mother and newborn for 4 years after delivery. Our case report confirms that omalizumab is a safe and effective therapeutic option, after careful evaluations in terms of cost-effectiveness, in pregnant and lactating women with severe chronic urticaria. Assessment throughout follow-up confirmed a regular progression of pregnancy parameters and no adverse reaction was documented in the child from birth to 4 years of age.

scholarly journals Fludarabine and rituximab for relapsed or refractory hairy cell leukemia

Blood ◽  
2012 ◽  
Vol 119 (9) ◽  
pp. 1988-1991 ◽  
Author(s):  
Alina S. Gerrie ◽  
Leslie N. Zypchen ◽  
Joseph M. Connors
Keyword(s):  
Hairy Cell Leukemia ◽  
Therapeutic Option ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
First Line ◽  
Response Data ◽  
Purine Analog ◽  
Duration Of Response ◽  
Effective Therapeutic Option

Abstract The purine analogs, pentostatin and cladribine, induce high remission rates when used as first-line monotherapy for hairy cell leukemia (HCL); however, patients continue to relapse. Re-treatment with the same or alternate purine analog produces lower response rates and a shorter duration of response. Fludarabine is another purine analog widely used in indolent lymphoid cancers, often in combination with rituximab, but there are few reports of its use in HCL. We identified 15 patients treated in British Columbia with fludarabine and rituximab (FR) from 2004 to 2010 for relapsed/refractory HCL after first-line cladribine (n = 3) or after multiple lines of therapy (n = 12). All patients with available response data responded to FR. With median follow-up of 35 months, 14 patients remain progression-free, whereas 1 patient has developed progressive leukemia and died. Five-year progression-free and overall survivals are 89% and 83%, respectively. FR is a safe and effective therapeutic option for relapsed/refractory HCL.

scholarly journals Transoral incisionless fundoplication with EsophyX for gastroesophageal reflux disease: clinical efficacy is maintained up to 10 years

2019 ◽  
Vol 07 (05) ◽  
pp. E647-E654 ◽  
Author(s):  
Pier Testoni ◽  
Sabrina Testoni ◽  
Giovanni Distefano ◽  
Giorgia Mazzoleni ◽  
Lorella Fanti ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Therapeutic Option ◽  
Transoral Incisionless Fundoplication ◽  
Related Quality ◽  
Effective Therapeutic Option ◽  
Health Related ◽  
Lost To Follow Up

Abstract Background Transoral incisionless fundoplication with EsophyX is reported to be effective in patients with gastroesophageal reflux disease in short-medium term follow-up. Aim To examine clinical outcomes up to 10 years. Methods In total, 51 procedures were performed in 50 patients. All entered a yearly clinical follow-up schedule including gastroesophageal reflux disease health-related quality-of-life questionnaires, heartburn and regurgitation scores, and daily proton pump inhibitor consumption. Results The procedure was successfully performed in 49/50 patients. Severe complications occurred in 2/51 procedures. The remaining 49 patients were re-evaluated at 2 and 3 years, 41 after 5 years, 30 after 7 years, and 14 after 10 years. Eight patients were lost to follow-up between 3 and 5 years. Seven patients who were unresponsive to endoscopic fundoplication underwent surgical fundoplication. The mean scores at 2 years were significantly lower than before the procedure and did not change substantially during the follow-up. The rates of patients who had stopped or halved antisecretive therapy 2, 3, 5, 7, and 10 years after the procedure were 86.7 %, 84.4 %, 73.5 %, 83.3 %, and 91.7 %, respectively. Conclusions Transoral incisionless fundoplication with EsophyX is an effective therapeutic option for symptomatic gastroesophageal reflux disease patients, with Hill grades I – II or hiatal hernia < 2 cm, who refuse life-long medical therapy or surgery.

scholarly journals A global approach for plantar fasciitis with extracorporeal shockwaves treatment

2019 ◽  
Vol 29 (3) ◽  
Author(s):  
Federico Giordani ◽  
Andrea Bernini ◽  
Hannes Müller-Ehrenberg ◽  
Carla Stecco ◽  
Stefano Masiero
Keyword(s):  
Plantar Fasciitis ◽  
Therapeutic Option ◽  
Plantar Fascia ◽  
Outcome Evaluation ◽  
Foot And Ankle ◽  
Global Approach ◽  
Functional Index ◽  
Standard Application ◽  
Effective Therapeutic Option

Extracorporeal Shockwaves Treatment is considered an effective therapeutic option for plantar fasciitis, but the standard application in the medial insertion of the plantar fascia on the calcaneus has provided ambiguous evidences. In this case, a 63-year man with plantar fasciitis was treated in a 3-session program and Foot and Ankle Outcome Scale and Foot Functional Index questionnaires were chosen for the clinical outcome evaluation. The therapy was focused on the active trigger or myofascial points of the leg, thigh and pelvis in order to return the correct equilibrium of the myofascial system of the whole limb. The patient has already reported an improvement after the second session (FAOS: 76 vs 33, FFI: 85%) which was confirmed in the third one and in the 1-month follow up (FAOS: 79, FFI: 6%) Results suggest that plantar fasciitis may be due to proximal rigidity or tension of the fascia and a global approach using ESWT may have a similar or better outcome respect to the standard application.

Successful Anterior Capsulotomy in Comorbid Anorexia Nervosa and Obsessive-Compulsive Disorder: Case Report

Neurosurgery ◽  
2011 ◽  
Vol 69 (3) ◽  
pp. E745-E751 ◽  
Author(s):  
Johan Barbier ◽  
Loes Gabriëls ◽  
Koen van Laere ◽  
Bart Nuttin
Keyword(s):  
Anorexia Nervosa ◽  
Case Report ◽  
Obsessive Compulsive Disorder ◽  
Therapeutic Option ◽  
Controlled Study ◽  
Obsessive Compulsive ◽  
Eating Pattern ◽  
Compulsive Disorder ◽  
Anterior Capsulotomy

Abstract BACKGROUND AND IMPORTANCE: State-of-the-art treatment of anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) often proves ineffective. Both disorders have common features, and anterior capsulotomy is a last-resort treatment for OCD. We document the effect of bilateral anterior capsulotomy in a patient with comorbid AN and OCD. CLINICAL PRESENTATION: A 38-year-old woman with life-threatening, chronic, treatment-refractory AN and OCD underwent anterior capsulotomy. Psychiatric and neuropsychological evaluations at baseline and at follow-up document the severity and progress of the case. Bilateral anterior capsulotomy resulted in normalization of eating pattern and weight and a significant decrease of food-related and overall obsessive-compulsive symptoms. Psychiatric evaluations and exposure to food cues confirmed the clinical improvement that was evident immediately after surgery and sustained at 3-month follow-up. CONCLUSION: This case report suggests that bilateral anterior capsulotomy can be a therapeutic option for patients with comorbid AN and OCD. However, a well-controlled study is warranted.

Does Radioactive Iodine Therapy for Hyperthyroidism Cause Cancer?

2021 ◽  
Author(s):  
Brian W Kim
Keyword(s):  
Radioactive Iodine ◽  
Therapeutic Option ◽  
Cancer Breast ◽  
Increased Risk ◽  
Effective Therapeutic Option ◽  
Autonomously Functioning Thyroid Nodules ◽  
Observational Cohort ◽  
The Subject ◽  
Risk Of Cancer

Abstract Radioactive iodine has been considered a safe and effective therapeutic option for hyperthyroidism secondary to Graves disease and autonomously functioning thyroid nodules since the mid-20th century. The question of whether I-131 at the doses used for hyperthyroidism might increase the risk of cancer has been investigated in a number of observational cohort studies over the years, with the preponderance of evidence being reassuring as to its safety. In particular, the 1998 Cooperative Thyrotoxicosis Therapy Follow-up Study (CTTFUS) has been widely cited as compelling evidence that I-131 is safe in hyperthyroidism therapy with respect to carcinogenesis. However, in 2019, a study by Kitahara and colleagues re-analyzed the CTTFUS cohort, extending the follow-up time and applying a novel dosimetric model for estimating tissue absorbed doses of radiation. This new analysis concluded that radioactive iodine was associated with an increased risk for mortality from overall cancer, breast cancer, and non-breast solid cancers. Reaction to this study was vociferous and particularly negative in the nuclear medicine literature. This mini-review was inspired by the 2019 CTTFUS controversy, and it is intended to provide the necessary context for clinicians to provide nuanced advice to their patients on the subject. To that end, the pre-2019 literature is surveyed, the 2019 CTTFUS study and a 2020 follow-up are discussed, and lessons from the literature and critical commentaries are considered.

scholarly journals EFFECTIVENESS OF ORAL AND TOPICAL UNANI FORMULATIONS IN TAQASHSHUR AL-JILD (PSORIASIS): A CASE STUDY

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Bhoraniya Abdullah Ismail ◽  
Ansari Umme Ammara Maqbool Ahmad ◽  
Juveria Jabeen ◽  
Mohd Afsahul Kalam
Keyword(s):  
Case Report ◽  
Adverse Effects ◽  
Skin Disorder ◽  
Unani Medicine ◽  
Treatment And Prevention ◽  
Scalp Psoriasis ◽  
Autoimmune Inflammatory Disease ◽  
Prevention Of Recurrence

Taqashshur al-Jild (Psoriasis) is an Autoimmune Inflammatory disease with a worldwide prevalence of about 1.5 -2%. A 27 years old male patient, approached the outpatient department of the N ational Research Institute of Unani Medicine for Skin Disorder (NRIUMSD), Hyderabad, with complaints of itching, scaling like dandruff, bleeding, burning of the scalp for one month. The examination of the skin revealed Psoriasis of the scalp. The patient was treated with the Unani regimen comprising of compound formulations Itrifal Shahetra (oral) 5gm, Habb-i-Musaffi Khoon (oral) 2 tablets, Marham Safed Kafoori (Topical), and Roghan Kamela (Topical) over scalp twice daily for 8 weeks days. The patient did not report any adverse effects during and after the treatment. After 8 weeks days of treatment, the whole scalp showed absence of the sign and symptoms of the disease. There was no recurrence of the disease during the next 2 months of post-treatment follow-up. This case report documented the successful treatment and prevention of recurrence of scalp psoriasis through Unani medicines. It concluded that the Unani regimen is effective and safe in the management of scalp psoriasis.

Lateral transorbital canthopexy using a silicone tube in patients with paralytic ectropion

2021 ◽  
pp. 112067212199053
Author(s):  
María G González-Cannata ◽  
Diana I González-Hinojosa ◽  
Karla J Aguilera-Ruíz ◽  
Martha P González-Núñez ◽  
Alfredo Medina-Zarco ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Lower Eyelid ◽  
Corneal Surface ◽  
Silicone Tube ◽  
Cosmetic Results ◽  
Effective Therapeutic Option ◽  
Over Time

Purpose: We describe the efficacy of lateral transorbital canthopexy using a silicone tube in managing severe paralytic ectropion. Methods: Patients with paralytic ectropion involving at least two-third of lower eyelid length and scleral exposure of 3 mm or more were considered. A silicone prosthetic was inserted during canthopexy. Results: Lateral transorbital canthopexy using a silicone tube was performed on 10 eyelids in nine patients. All patients had corneal surface abnormalities. Scleral exposure resolved completely in three cases. At 8-month follow-up, residual scleral exposure of 1 mm and 2 mm persisted in n = 6 and n = 1 cases, respectively. Conclusions: Lateral transorbital canthopexy using a silicone tube is an effective therapeutic option for paralytic ectropion, facilitating both functional and cosmetic results that proved durable over time.

Radiosynovectomy for the treatment of rheumatoid arthritis of the elbow

2001 ◽  
Vol 40 (03) ◽  
pp. 91-97 ◽  
Author(s):  
S. Rozeboom ◽  
H. Bihl ◽  
U. Dörr
Keyword(s):  
Therapeutic Option ◽  
Impaired Mobility ◽  
Objective Parameter ◽  
Flexion Extension ◽  
Temporary Response ◽  
Effective Therapeutic Option ◽  
Articular Pain ◽  
Term Response

SummaryThe Aim of this retrospective study was to evaluate the efficiacy of radiosynovectomy (RSO) in patients with rheumatoid elbow arthritis. Patients and Methods: 40 joints of 31 patients were evaluated. At the time of therapy, patients had been suffering from elbow arthritis for 17.5 months (2-72 months). 95% of the joints (n = 38) had severe dally pain or continuous pain, 97.5% (n = 39) had moderate to severe limitation of the mobility and 10% (n = 4) had severe swelling. RSO was performed by intraarticular injection of 74 MBq colloidal rhenium-l 86 and 15 mg triamcinolonehex-acetonide. Before and six to 26 months after therapy (median follow-up 14.7 months) severity of the patients pain, mobility and swelling (transferred to a scoring system) were determined with a standardised questional. A clinical re-evaluation, along with an ar-throsonographical follow-up was performed in 28 joints. Results: A “good to very good” overall long-term response was achieved in 80% (n = 32) of the treated joints and a temporary response in 10% (n = 4). Only 10% (n = 4) had a non-satisfactory response due to advanced articular destruction. The range of motion for flexion-extension increased from 103.8 ± 20.0 degrees to 144.0 ±12.8 degrees (p <0.001). The respective scores for articular pain, impaired mobility and swelling decreased significantly (pain from 3.15 to 0.82, impaired mobility from 3.15 to 0.82, swelling from 2.40 to 0.65; p <0.00U. No deterioration or complication occurred. The effects lasted throughout the entire follow-up time for 36 joints (90%). Conclusion: For patients with rheumatoid involvement of the elbow joint, radiosynovectomy results in a significant decrease of articular pain and improvement of objective parameter, i.e. joint mobility. Thus, radiosynovectomy represents a feasible and effective therapeutic option for elbow arthritis.

scholarly journals Subcutaneous nodules in children: Don’t forget deep granuloma annulare: A Case Report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2093571
Author(s):  
Zhuo Ran Cai ◽  
Françoise Mamet ◽  
Viktor Kokta ◽  
Jérôme Coulombe
Keyword(s):  
Case Report ◽  
Skin Disorder ◽  
Surgical Excision ◽  
Paediatric Population ◽  
Granuloma Annulare ◽  
Rheumatoid Nodule ◽  
Limited Disease ◽  
Surgical Interventions ◽  
Subcutaneous Nodules

Deep granuloma annulare is an uncommon benign granulomatous skin disorder that presents almost exclusively in the paediatric population. It presents as an asymptomatic subcutaneous nodule with normal overlying skin on distal extremities, the scalp, or the forehead. It shows a deep palisading granuloma with areas of central necrobiosis on histologic examination. Due to its self-limited nature, clinical follow-up is recommended over surgical interventions. We present a case of cephalic deep granuloma annulare in a healthy 5-year-old girl who remains free of recurrence after surgical excision at the 6-month follow-up. Our case emphasizes the importance of differentiating the lesion from its clinical and histopathological mimickers, such as the rheumatoid nodule. The awareness of this entity is important to avoid the overinvestigation and overtreatment of a benign and self-limited disease.

scholarly journals Compound odontoma in the anterior region of the mandible: clinical case report

2021 ◽  
Vol 10 (13) ◽  
pp. e50101320987
Author(s):  
Eduardo Quintão Manhanini Souza ◽  
Vinícius Franzão Ganzaroli ◽  
Igor Rodrigues de Almeida ◽  
Jéssica de Oliveira Alvarenga Freire ◽  
Luy de Abreu Costa ◽  
...  
Keyword(s):  
Case Report ◽  
Therapeutic Option ◽  
Anterior Region ◽  
Permanent Teeth ◽  
Deciduous Teeth ◽  
Unknown Etiology ◽  
Surgical Removal ◽  
Dental Tissues ◽  
Compound Odontoma

Odontomas are classified as a malformation where epithelial and mesenchymal cells have the ability to produce dental tissues such as enamel and dentin. Of unknown etiology, they are often associated with failure of eruption of permanent teeth and / or late impaction or exfoliation of deciduous teeth. Surgical removal is the therapeutic option of choice for the treatment of this condition, since its presence can cause some intercurrences as root resorptions of the neighboring teeth. The objective of this case report is to describe a surgical approach for the removal of a composite odontoma in the anterior region of the mandible, where after a 5-year postoperative follow-up, it was possible to observe in radiographic and tomographic analyses, small images of radiopaque characteristic compatible with recurrence tumor, hypercalcification or remnant of the lesion.

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