Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review

BACKGROUND: WHO declared the coronavirus disease (COVID)-19 outbreaks as a worldwide pandemic in March 2020. More than 1,500,000 confirmed cases have been diagnosed in more than 130 countries and regions, estimated to cause 93,000 deaths so far recorded on April 10, 2020. There is no vaccine or antiviral treatment for coronavirus. METHODS: The literature sources from the research were obtained by searching for national and international journals. The journal is indexed in Google Scholar, PubMed, Science Direct, e-books, and others. Five journals were obtained, including a literature review, systematic review, and randomized controlled trials (RCT) discussing the use of dexamethasone in COVID-19 therapy, Middle East respiratory syndrome, and severe acute respiratory syndrome. RESULTS: A study from Oxford University compared 2100 COVID-19 patients who received low and moderate potential dexamethasone at a dose of 6 mg/day for 10 days with 4300 COVID-19 patients who only received standard treatment for coronavirus infection. The results obtained in patients using ventilator mortality decreased from 40% to 28%, and patients using oxygen, the mortality rate decreased from 40% to 20%. The dexamethasone RCT study can reduce the death rate of 1 in 3 COVID-19 patients who received mechanical ventilation therapy and 1 in 5 patients who received oxygen therapy without mechanical ventilation but did not reduce patients’ mortality rate who did not receive therapy oxygen. CONCLUSION: The use of dexamethasone with oxygen therapy and mechanical ventilation can reduce mortality patients with COVID-19.

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The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis

Frontiers in Public Health ◽

10.3389/fpubh.2021.624559 ◽

2021 ◽

Vol 9 ◽

Author(s):

Amare Teshome ◽

Aynishet Adane ◽

Biruk Girma ◽

Zeleke A. Mekonnen

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Conclusive Evidence ◽

Qualitative Synthesis ◽

Vitamin D Levels ◽

Coronavirus Infection ◽

Sufficient Vitamin ◽

The Impact

Background: Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or novel Coronavirus (nCoV). To date, there is no proven curative treatment for this virus; as a result, prevention remains to be the best strategy to combat coronavirus infection (COVID-19). Vitamin D deficiency (VDD) has been proposed to play a role in coronavirus infection (COVID-19). However, there is no conclusive evidence on its impact on COVID-19 infection. Therefore, the present review aimed to summarize the available evidence regarding the association between Vitamin D levels and the risk of COVID-19 infection.Methods: A systematic literature search of databases (PUBMED/MEDLINE, Cochrane/Wiley library, Scopus, and SciELO) were conducted from May 15, 2020, to December 20, 2020. Studies that assessed the effect of vitamin D level on COVID-19/SARS-2 infection were considered for the review. The qualities of the included studies were evaluated using the JBI tools. Meta-analysis with a random-effects model was conducted and odds ratio with their 95%CI were reported. This systematic review and meta-analysis are reported according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline.Results: The electronic and supplementary searches for this review yielded 318 records from which, only 14 of them met the inclusion criteria. The qualitative synthesis indicated that vitamin D deficient individuals were at higher risk of COVID-19 infection as compared to vitamin D sufficient patients. The pooled analysis showed that individuals with Vitamin-D deficiency were 80% more likely to acquire COVID-19 infection as compared to those who have sufficient Vitamin D levels (OR = 1.80; 95%CI: 1.72, 1.88). Begg's test also revealed that there was no significant publication bias between the studies (P = 0.764). The subgroup analysis revealed that the risk of acquiring COVID-19 infection was relatively higher in the case-control study design (OR = 1.81).Conclusions: In conclusion, low serum 25 (OH) Vitamin-D level was significantly associated with a higher risk of COVID-19 infection. The limited currently available data suggest that sufficient Vitamin D level in serum is associated with a significantly decreased risk of COVID-19 infection.

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Novel coronavirus infection (COVID‐19) in children younger than one year: A systematic review of symptoms, management and outcomes

Acta Paediatrica ◽

10.1111/apa.15422 ◽

2020 ◽

Vol 109 (10) ◽

pp. 1948-1955 ◽

Cited By ~ 5

Author(s):

Ali Ahmed Raba ◽

Anis Abobaker ◽

Ismail Suliman Elgenaidi ◽

Ahmed Daoud

Keyword(s):

Systematic Review ◽

Coronavirus Infection ◽

One Year ◽

Novel Coronavirus

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Thrombotic and Hemorrhagic Incidences in Patients After Discharge from COVID-19 Infection: A Systematic Review and Meta-Analysis

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/10760296211069082 ◽

2021 ◽

Vol 27 ◽

pp. 107602962110690

Author(s):

Tarinee Rungjirajittranon ◽

Weerapat Owattanapanich ◽

Nattawut Leelakanok ◽

Natthaporn Sasijareonrat ◽

Bundarika Suwanawiboon ◽

...

Keyword(s):

Systematic Review ◽

Search Strategy ◽

Meta Analysis ◽

Thrombotic Risk ◽

Medically Ill ◽

Current Systematic Review ◽

Arcsine Transformation ◽

Thrombotic Complications ◽

Coronavirus Infection ◽

Medically Ill Patients

Background The association between coronavirus infection 2019 (COVID-19) and thrombosis has been explicitly shown through numerous reports that demonstrate high rates of thrombotic complications in infected patients. Recently, much evidence has shown that patients who survived COVID-19 might have a high thrombotic risk after hospital discharge. This current systematic review and meta-analysis was conducted to better understand the incidence of thrombosis, bleeding, and mortality rates among patients discharged after COVID-19 hospitalization. Methods Using a search strategy that included terms for postdischarge, thrombosis, and COVID-19, 2 investigators independently searched for published articles indexed in the MEDLINE, Embase, and Scopus databases that were published before August 2021. Pooled incidences and 95% confidence intervals were calculated using the DerSimonian-Laird random-effects model with a double arcsine transformation. Results Twenty articles were included in the meta-analysis. They provided a total of 19 461 patients discharged after COVID-19 hospitalization. The weighted pooled incidence of overall thrombosis among the patients was 1.3% (95 CI, 0. 6-2; I2 90.5), with a pooled incidence of venous thrombosis of 0.7% (95 CI, 0. 4-1; I2 73.9) and a pooled incidence of arterial thrombosis of 0.6% (95 CI, 0. 2-1; I2 88.1). The weighted pooled incidences of bleeding and mortality were 0.9% (95 CI, 0. 1-1.9; I2 95.1) and 2.8% (95 CI, 0. 6-5; I2 98.2), respectively. Conclusions The incidences of thrombosis and bleeding in patients discharged after COVID-19 hospitalization are comparable to those of medically ill patients.

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Herbal Medicine for the Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review

Indian Journal of Pure & Applied Biosciences ◽

10.18782/2582-2845.8757 ◽

2021 ◽

Vol 9 (4) ◽

pp. 50-53

Author(s):

S Rehan Ahmad ◽

Keyword(s):

Systematic Review ◽

Herbal Medicine ◽

Blood Plasma ◽

Human Blood ◽

Hand Washing ◽

Human Blood Plasma ◽

Nasal Drop ◽

Coronavirus Infection

Till now Coronavirus (COVID-19) has taken ~ 0.43 million lives and infected ~ 7.6 million people and the process is continuing. Face masks and regular hand-washing are the two main ways to help prevent the transmission of Coronavirus. But wearing face masks and regular hand-washing have not sufficient to stop the transmission of Coronavirus. This leads a modification needed for the procedure of prevention from Coronavirus infection. Thus the knowledge about spreading and infecting mechanism by the Coronavirus is desired (Garai, 2020). Instead of using soap and alcohol base sanitizer NaHCO3 solution can used for hand-washing to prevent from Coronavirus infection. As NaHCO3 is very cheap and less hazardous than soap and alcohol base sanitizer so this change will be economically profitable and environmentally safer (less hazard). NaHCO3 solution can also be used as nasal drop and gargle solution for the protection of nose mucus and mouth saliva from Coronavirus infection. Thus NaHCO3 solution give extra protection from Coronavirus infection when it used with mask (Garai, 2020). Beside that considering the biological immovability of NaHCO3 (mainly in human blood plasma), it is strongly recommended to use NaHCO3 for the treatment of Coronavirus patients too.

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