The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal–fetal transmission: a systematic review and meta-analysis

Background: Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or novel Coronavirus (nCoV). To date, there is no proven curative treatment for this virus; as a result, prevention remains to be the best strategy to combat coronavirus infection (COVID-19). Vitamin D deficiency (VDD) has been proposed to play a role in coronavirus infection (COVID-19). However, there is no conclusive evidence on its impact on COVID-19 infection. Therefore, the present review aimed to summarize the available evidence regarding the association between Vitamin D levels and the risk of COVID-19 infection.Methods: A systematic literature search of databases (PUBMED/MEDLINE, Cochrane/Wiley library, Scopus, and SciELO) were conducted from May 15, 2020, to December 20, 2020. Studies that assessed the effect of vitamin D level on COVID-19/SARS-2 infection were considered for the review. The qualities of the included studies were evaluated using the JBI tools. Meta-analysis with a random-effects model was conducted and odds ratio with their 95%CI were reported. This systematic review and meta-analysis are reported according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline.Results: The electronic and supplementary searches for this review yielded 318 records from which, only 14 of them met the inclusion criteria. The qualitative synthesis indicated that vitamin D deficient individuals were at higher risk of COVID-19 infection as compared to vitamin D sufficient patients. The pooled analysis showed that individuals with Vitamin-D deficiency were 80% more likely to acquire COVID-19 infection as compared to those who have sufficient Vitamin D levels (OR = 1.80; 95%CI: 1.72, 1.88). Begg's test also revealed that there was no significant publication bias between the studies (P = 0.764). The subgroup analysis revealed that the risk of acquiring COVID-19 infection was relatively higher in the case-control study design (OR = 1.81).Conclusions: In conclusion, low serum 25 (OH) Vitamin-D level was significantly associated with a higher risk of COVID-19 infection. The limited currently available data suggest that sufficient Vitamin D level in serum is associated with a significantly decreased risk of COVID-19 infection.

Download Full-text

Thrombotic and Hemorrhagic Incidences in Patients After Discharge from COVID-19 Infection: A Systematic Review and Meta-Analysis

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/10760296211069082 ◽

2021 ◽

Vol 27 ◽

pp. 107602962110690

Author(s):

Tarinee Rungjirajittranon ◽

Weerapat Owattanapanich ◽

Nattawut Leelakanok ◽

Natthaporn Sasijareonrat ◽

Bundarika Suwanawiboon ◽

...

Keyword(s):

Systematic Review ◽

Search Strategy ◽

Meta Analysis ◽

Thrombotic Risk ◽

Medically Ill ◽

Current Systematic Review ◽

Arcsine Transformation ◽

Thrombotic Complications ◽

Coronavirus Infection ◽

Medically Ill Patients

Background The association between coronavirus infection 2019 (COVID-19) and thrombosis has been explicitly shown through numerous reports that demonstrate high rates of thrombotic complications in infected patients. Recently, much evidence has shown that patients who survived COVID-19 might have a high thrombotic risk after hospital discharge. This current systematic review and meta-analysis was conducted to better understand the incidence of thrombosis, bleeding, and mortality rates among patients discharged after COVID-19 hospitalization. Methods Using a search strategy that included terms for postdischarge, thrombosis, and COVID-19, 2 investigators independently searched for published articles indexed in the MEDLINE, Embase, and Scopus databases that were published before August 2021. Pooled incidences and 95% confidence intervals were calculated using the DerSimonian-Laird random-effects model with a double arcsine transformation. Results Twenty articles were included in the meta-analysis. They provided a total of 19 461 patients discharged after COVID-19 hospitalization. The weighted pooled incidence of overall thrombosis among the patients was 1.3% (95 CI, 0. 6-2; I2 90.5), with a pooled incidence of venous thrombosis of 0.7% (95 CI, 0. 4-1; I2 73.9) and a pooled incidence of arterial thrombosis of 0.6% (95 CI, 0. 2-1; I2 88.1). The weighted pooled incidences of bleeding and mortality were 0.9% (95 CI, 0. 1-1.9; I2 95.1) and 2.8% (95 CI, 0. 6-5; I2 98.2), respectively. Conclusions The incidences of thrombosis and bleeding in patients discharged after COVID-19 hospitalization are comparable to those of medically ill patients.

Download Full-text

Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis

Frontiers in Neurology ◽

10.3389/fneur.2020.579070 ◽

2020 ◽

Vol 11 ◽

Cited By ~ 1

Author(s):

Kai Wei Lee ◽

Abdul Hanif Khan Yusof Khan ◽

Siew Mooi Ching ◽

Peck Kee Chia ◽

Wei Chao Loh ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Coronavirus Infection ◽

Novel Coronavirus

Download Full-text

The Impact of Coronavirus Disease 2019 (COVID-19) on Liver Injury in China: A Systematic Review and Meta-analysis

10.1101/2020.05.03.20089557 ◽

2020 ◽

Cited By ~ 1

Author(s):

Xin Zhao ◽

Zehua Lei ◽

Fengwei Gao ◽

Qingyun Xie ◽

Kangyi Jang ◽

...

Keyword(s):

Systematic Review ◽

Quantitative Analysis ◽

Liver Injury ◽

Risk Ratio ◽

Meta Analysis ◽

Chinese Patients ◽

Icu Patients ◽

Changing Trend ◽

Coronavirus Infection ◽

The Impact

AbstractBackgroundThe evidence for the incidence and severity of liver injury in Chinese patients with COVID-19 is still controversial.AimsThe purpose of this study was to summarize the incidence of liver injury and the differences between liver injury markers among different patients with COVID-19 in China.MethodsComputer searches of PubMed, Embase, CNKI and medRxiv were used to obtain reports on the incidence and markers of liver injury in Chinese patients with COVID-19, from January 1, 2020 to April 10, 2020. (No. CRD42020181350)ResultsA total of 57 reports from China were included, including 9889 confirmed cases of COVID-19 infection. The results of the meta-analysis showed that among the patients with early COVID-19 infection in China, the incidence of liver injury events was 24.7% (95% CI, 23.4%-26.4%). Liver injury in severe patients was more common than that in non-severe patients, with a risk ratio of 2.07 (95% CI, 1.77 to 2.43). Quantitative analysis showed that the severe the coronavirus infection, the higher the level of AST, ALT, TB, ALP, GGT and the lower the level of ALB. The changing trend of the appeal index was similar in ICU patients and dead patients.ConclusionThere is a certain risk of liver injury in Chinese patients with COVID-19, and the risk and degree of liver injury are related to the severity of COVID-19.

Download Full-text

Efficacy of cloth face mask in prevention of novel coronavirus infection transmission: A systematic review and meta-analysis

Journal of Education and Health Promotion ◽

10.4103/jehp.jehp_533_20 ◽

2020 ◽

Vol 9 (1) ◽

pp. 192

Author(s):

SureshK Sharma ◽

Mayank Mishra ◽

ShivK Mudgal

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Face Mask ◽

Infection Transmission ◽

Coronavirus Infection ◽

Novel Coronavirus

Download Full-text

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

Food & Function ◽

10.1039/d0fo01976c ◽

2021 ◽

Author(s):

Yali Wei ◽

Yan Meng ◽

Na Li ◽

Qian Wang ◽

Liyong Chen

Keyword(s):

Systematic Review ◽

Fatty Acid ◽

Polyunsaturated Fatty Acid ◽

Meta Analysis ◽

Chain Polyunsaturated Fatty Acid ◽

Inflammation Markers ◽

Pufa Supplementation ◽

Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

Download Full-text