Counting invasive breast cancer cells in the HER2 silver in-situ hybridization test: how many cells are enough?

2017 ◽  
Vol 71 (2) ◽  
pp. 247-257 ◽  
Author(s):  
António Polónia ◽  
Catarina Eloy ◽  
João Pinto ◽  
Ana Costa Braga ◽  
Guilherme Oliveira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
In Situ Hybridization ◽  
Cancer Cells ◽  
Invasive Breast Cancer ◽  
Breast Cancer Cells ◽  
Hybridization Test ◽  
Silver In Situ Hybridization

Quantification of C-ERB-B2 gene amplification in breast cancer cells using fluorescence in situ hybridization and digital image analysis

1996 ◽  
Vol 86 (1) ◽  
pp. 18-21 ◽  
Author(s):  
JoséLuis Fernández ◽  
Vicente Goyanes ◽  
Carmen López-Fernández ◽  
Ismael Buñot ◽  
Jaime Gosálvez
Keyword(s):  
Breast Cancer ◽  
Image Analysis ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Cancer Cells ◽  
Gene Amplification ◽  
Digital Image ◽  
Breast Cancer Cells ◽  
Digital Image Analysis

scholarly journals Analysis of centromere signal patterns in breast cancer cells with chromosomal instability using image cytometry combined with centromere fluorescence in situ hybridization

2014 ◽  
Vol 85 (9) ◽  
pp. 809-816 ◽  
Author(s):  
Hideaki Ito ◽  
Atsunori Oga ◽  
Kenzo Ikemoto ◽  
Tomoko Furuya ◽  
Noriko Maeda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Cancer Cells ◽  
Chromosomal Instability ◽  
Breast Cancer Cells ◽  
Image Cytometry

HER-2 protein concentrations in breast cancer cells increase before immunohistochemical and fluorescence in situ hybridization analysis turn positive

2007 ◽  
Vol 45 (2) ◽  
Author(s):  
Dorte A. Olsen ◽  
Birthe Østergaard ◽  
Susanne Bokmand ◽  
Peter A. Wamberg ◽  
Erik H. Jakobsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Hybridization Analysis ◽  
Her 2

AbstractClin Chem Lab Med 2007;45:177–82.

A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour–stroma interactions

Lab on a Chip ◽  
2017 ◽  
Vol 17 (16) ◽  
pp. 2852-2860 ◽  
Author(s):  
Qihui Fan ◽  
Ruchuan Liu ◽  
Yang Jiao ◽  
Chunxiu Tian ◽  
James D. Farrell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Invasive Breast Cancer ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Microfluidic System ◽  
Tumour Stroma ◽  
Collagen Hydrogel

A 3-D microfluidic system consisting of microchamber arrays embedded in a collagen hydrogel with tunable biochemical gradients was constructed for investigating interactions between invasive breast cancer cells and stromal cells.

scholarly journals TLR4 Ligand/H2O2 Enhances TGF-β1 Signaling to Induce Metastatic Potential of Non-Invasive Breast Cancer Cells by Activating Non-Smad Pathways

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e65906 ◽  
Author(s):  
Yuan-Hong Zhou ◽  
Sheng-Jun Liao ◽  
Dong Li ◽  
Jing Luo ◽  
Jing-Jing Wei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Invasive Breast Cancer ◽  
Breast Cancer Cells ◽  
Metastatic Potential ◽  
Non Invasive ◽  
Tlr4 Ligand ◽  
Tgf Β1

scholarly journals The Differential Distribution of RAPTA-T in Non-Invasive and Invasive Breast Cancer Cells Correlates with Its Anti-Invasive and Anti-Metastatic Effects

2017 ◽  
Vol 18 (9) ◽  
pp. 1869 ◽  
Author(s):  
Ronald Lee ◽  
Stéphane Escrig ◽  
Catherine Maclachlan ◽  
Graham Knott ◽  
Anders Meibom ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Invasive Breast Cancer ◽  
Breast Cancer Cells ◽  
Differential Distribution ◽  
Non Invasive

scholarly journals Twist-mediated PAR1 induction is required for breast cancer progression and metastasis by inhibiting Hippo pathway

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Yifan Wang ◽  
Ruocen Liao ◽  
Xingyu Chen ◽  
Xuhua Ying ◽  
Guanping Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Invasive Breast Cancer ◽  
Breast Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Hippo Pathway ◽  
Breast Cancer Patients ◽  
Mesenchymal Transition

Abstract Breast cancer is considered to be the most prevalent cancer in women worldwide, and metastasis is the primary cause of death. Protease-activated receptor 1 (PAR1) is a GPCR family member involved in the invasive and metastatic processes of cancer cells. However, the functions and underlying mechanisms of PAR1 in breast cancer remain unclear. In this study, we found that PAR1 is highly expressed in high invasive breast cancer cells, and predicts poor prognosis in ER-negative and high-grade breast cancer patients. Mechanistically, Twist transcriptionally induces PAR1 expression, leading to inhibition of Hippo pathway and activation of YAP/TAZ; Inhibition of PAR1 suppresses YAP/TAZ-induced epithelial-mesenchymal transition (EMT), invasion, migration, cancer stem cell (CSC)-like properties, tumor growth and metastasis of breast cancer cells in vitro and in vivo. These findings suggest that PAR1 acts as a direct transcriptionally target of Twist, can promote EMT, tumorigenicity and metastasis by controlling the Hippo pathway; this may lead to a potential therapeutic target for treating invasive breast cancer.

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