A potential trackable bone filler: Preparation and characterization

2021 ◽  
Author(s):  
Ali Kargar nigje ◽  
Esmaeil Salimi ◽  
Mohammad Jafar Molaei ◽  
Mojtaba Ghatee
Keyword(s):  
Bone Filler

scholarly journals Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Karen E. Beenken ◽  
Mara J. Campbell ◽  
Aura M. Ramirez ◽  
Karrar Alghazali ◽  
Christopher M. Walker ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Bone Defect ◽  
Rabbit Model ◽  
In Vivo Studies ◽  
Bovine Bone ◽  
Bone Filler ◽  
Antibiotic Release ◽  
Local Antibiotic ◽  
Antibiotic Delivery

AbstractWe previously reported the development of an osteogenic bone filler scaffold consisting of degradable polyurethane, hydroxyapatite, and decellularized bovine bone particles. The current study was aimed at evaluating the use of this scaffold as a means of local antibiotic delivery to prevent infection in a bone defect contaminated with Staphylococcus aureus. We evaluated two scaffold formulations with the same component ratios but differing overall porosity and surface area. Studies with vancomycin, daptomycin, and gentamicin confirmed that antibiotic uptake was concentration dependent and that increased porosity correlated with increased uptake and prolonged antibiotic release. We also demonstrate that vancomycin can be passively loaded into either formulation in sufficient concentration to prevent infection in a rabbit model of a contaminated segmental bone defect. Moreover, even in those few cases in which complete eradication was not achieved, the number of viable bacteria in the bone was significantly reduced by treatment and there was no radiographic evidence of osteomyelitis. Radiographs and microcomputed tomography (µCT) analysis from the in vivo studies also suggested that the addition of vancomycin did not have any significant effect on the scaffold itself. These results demonstrate the potential utility of our bone regeneration scaffold for local antibiotic delivery to prevent infection in contaminated bone defects.

scholarly journals Hard Tissue Preservation in Minimally Invasive Mandibular Third Molar Surgery Using In Situ Hardening TCP Bone Filler

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Wilfried Engelke ◽  
Marcio Lazzarini ◽  
Víctor Beltrán
Keyword(s):  
Inferior Alveolar Nerve ◽  
Third Molar ◽  
Case Series ◽  
Third Molar Surgery ◽  
Hard Tissue ◽  
Socket Preservation ◽  
Bone Filler ◽  
Close Relationship ◽  
Bone Height

Background. Maintenance of hard tissue in the case of impacted third molars (M3M) with close relationship to the mandibular canal is still a surgical challenge which may be overcome using the inward fragmentation technique. Methods. A consecutive case series of 12 patients required the extraction of 13 impacted M3M with a close relationship to the inferior alveolar nerve (IAN). Via occlusal miniflaps, M3M were exposed occlusal under endoscopic vision and removed by inward fragmentation. All patients received socket preservation with resorbable in situ hardening TCP particles to reduce the risk of pocket formation at the second molar. Results. All 13 sites healed uneventfully. Bone height was assessed using CBCT cross-sectional reformats pre- and 3 months postoperatively. The bone height was reduced by 1.54 mm lingual (SD 0.88), 2.91 mm central (SD 0.93), and 2.08 mm buccal (SD 1.09). Differences were significant at a 0.05% level. No tissue invagination at the extraction sites was observed. Conclusions. Major bone defects can be avoided safely using inward fragmentation surgery. The self-hardening bone filler appears to enhance the mineralization of the intrabony defect.

Characterization of biocomposites of sheep hydroxyapatite (SHA)/shellac/sugar as bone filler material

2018 ◽  
Author(s):  
Joko Triyono ◽  
Yushak Rizha ◽  
Teguh Triyono
Keyword(s):  
Filler Material ◽  
Bone Filler

Poly(D,L-lactide/∊-Caprolactone)/Hydroxyapatite Composites as Bone Filler: An in Vivo Study in Rats

2002 ◽  
Vol 25 (12) ◽  
pp. 1174-1179 ◽  
Author(s):  
A. şenköylü ◽  
E. Ural ◽  
K. Kesencì ◽  
A. şìmşek ◽  
ş. Ruacan ◽  
...  
Keyword(s):  
Ring Opening ◽  
Bone Growth ◽  
Bone Defects ◽  
Ring Opening Polymerization ◽  
New Bone Formation ◽  
The Third ◽  
Bone Filler ◽  
Green Polymer ◽  
Animal Tests

In this study, a novel composite bone substitute was implanted in animal models (rats) and their in vivo characteristics were examined. A D,L-lactide and ∊-caprolactone copolymer (Mw: 80,000; Mn:40,000, and PI:2.00) was synthesized by ring-opening polymerization of the respective dimers using stannous octoate as the catalyst. The final ratio of D,L-lactide to ∊-caprolactone obtained by 1NMR was 60/40. Hydroxyapatite (HA) powder was loaded in the copolymer. The HA/copolymer ratio was 60/40 (w/w). These composites were easily shaped by hand. Animal tests were performed on mature wistar rats (n=30). Defects were created on the proximal, the thickest part of the femur. The bone defects of the first group were filled with polymer/HA composite, the second group filled with only HA and the third group was left empty. Histologic examination of bone tissues showed new bone formation around the yellow-green polymer/HA composite material in the first group of animals whereas no evidence of new bone growth was observed in other groups.

A degradable soybean-based biomaterial used effectively as a bone filler in vivo in a rabbit

2010 ◽  
Vol 5 (1) ◽  
pp. 015008 ◽  
Author(s):  
Antonio Merolli ◽  
Luigi Nicolais ◽  
Luigi Ambrosio ◽  
Matteo Santin
Keyword(s):  
Bone Filler

Kyphon Bone Filler

2018 ◽  
Vol 48 (6) ◽  
pp. 44
Keyword(s):  
Bone Filler

Preparation and Characterization of β-Tricalcium Phosphate Powders with High Solubility for Chelate-Setting Calcium-Phosphate Cements

2017 ◽  
Vol 758 ◽  
pp. 194-198
Author(s):  
Kohei Nagata ◽  
Toshiisa Konishi ◽  
Michiyo Honda ◽  
Mamoru Aizawa
Keyword(s):  
Tricalcium Phosphate ◽  
Single Phase ◽  
Inositol Phosphate ◽  
Heating Temperature ◽  
Japanese Industrial Standard ◽  
Bone Filler ◽  
Setting Mechanism ◽  
Median Particle

We have previously developed a novel chelate-setting β-tricalcium phosphate (β-TCP) cement with non-fragmentation property in vivo. This novel cement has been set on the basis of chelate-setting mechanism of inositol phosphate (IP6). In this study, β-TCP powders were synthesized by mechanochemical method, and the as-prepared powders were heated at 600-1300°C for 1 h. Some properties of the resulting powders were examined. The crystalline phase of the resulting powders in the range of 600-1100°C was of β-TCP single phase. In the cases at 1200°C and 1300°C, the resulting powders were composed of β-TCP and α-TCP. Median particle sizes of the resulting powders increased with heating temperature from 5.35 μm up to 47.7 μm. Dissolution rate of Ca2+ ions from the β-TCP powders was measured by Japanese Industrial Standard T 0330-3. When the heating temperature was at 700°C, the Ca2+ ions solubility was highest among examined ones. The β-TCP powder heated at 700°C for 1 h will be expected as the starting powder for paste-like artificial bone filler with excellent bioresorbability.

Biomimetic Hydroxyapatite Micro-Tube Tissue Scaffold

2005 ◽  
Vol 284-286 ◽  
pp. 643-646 ◽  
Author(s):  
Elizabeth C. Kolos ◽  
Andrew Ruys ◽  
Ramin Rohanizadeh ◽  
M.M. Muir ◽  
Greg J. Roger
Keyword(s):  
Animal Studies ◽  
Osteoblast Cell ◽  
Tissue Scaffold ◽  
Future Studies ◽  
Support Cell ◽  
Cell Coverage ◽  
Bone Filler ◽  
Cotton Fibres ◽  
Biomimetic Method ◽  
Biomimetic Hydroxyapatite

The aim of this study was to fabricate a micro-tube scaffold using a biomimetic method (immersion in Simulated Body Fluid, SBF) to coat apatite on cotton fibres. The cotton fibres were first pre-treated using a phosphorylation technique and then apatite crystals were deposited on the fibres by immersing in SBF. Micro-tubes were then formed by burning out the cotton fibres at various temperatures between 950-1250°C. The scaffolds were fabricated by compaction of the micro-tubes in a mould. The compacted micro-tubes were then sintered at various temperatures between 900-1200°C. The biocompatibility and the effects of the surface morphology of scaffolds on cell coverage and proliferation were determined using osteoblast cell culture. The results showed that these scaddolds were biocompatible and able to support cell growth. Future studies include animal studies for biomimetic tissue scaffold as a bone filler substitute material.

Effect of vertebroplasty with bone filler device and comparison with balloon kyphoplasty

2014 ◽  
Vol 23 (12) ◽  
pp. 2718-2725 ◽  
Author(s):  
Dong-Hoon Yang ◽  
Ki Hong Cho ◽  
Young Sun Chung ◽  
Young Rae Kim
Keyword(s):  
Balloon Kyphoplasty ◽  
Bone Filler
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