scholarly journals Prognostic Value of C‐Reactive Protein to Albumin Ratio in Patients Resuscitated from Out‐of‐Hospital Cardiac Arrest

2021 ◽  
Author(s):  
Tugba Bingol Tanriverdi ◽  
Gulcin Patmano ◽  
Firdevs Tugba Bozkurt ◽  
Bedri Caner Kaya ◽  
Mehmet Tercan
Keyword(s):  
Cardiac Arrest ◽  
Prognostic Value ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Hospital Cardiac Arrest

scholarly journals Prognostic Value of C-Reactive Protein to Albumin Ratio in Patients Resuscitated from Out-of-Hospital Cardiac Arrest

2021 ◽  
Author(s):  
Tuğba Bingol Tanriverdi ◽  
Gulcin Patmano ◽  
Firdevs Tugba Bozkurt ◽  
Bedri Caner Kaya ◽  
Mehmet Tercan
Keyword(s):  
Cardiac Arrest ◽  
Lactate Level ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Lactate ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Cell Counts ◽  
Survivor Group ◽  
Hospital Cardiac Arrest

Background: Despite major advances in basic and advanced life supports, patients who survived from out of hospital cardiac arrest (OHCA) has still poor prognosis. Several inflammatory parameters have been used to determine early and long-term prognosis in patients with OHCA. C-reactive protein-to-albumin ratio (CAR) is also a novel marker of systemic inflammation. To our knowledge, there is no study evaluating the clinical importance of CAR in OHCA patients. Aims: To evaluate the effect of CAR on mortality in patients with OHCA. Methods: A total of 102 patients with OHCA were included in this study. The study population were divided into two groups as survivor (n = 43) and non-survivor (n = 59) during follow-up. Complete blood cell counts, biochemical and blood gas analysis were recorded for all patients. Neutrophil to lymphocyte ratio (NLR) was calculated as the ratio of neutrophil to lymphocyte. CAR was calculated as the ratio of CRP to the albumin. Results: NLR (P=0.012), CAR (P<0.001) and serum lactate level (P =0.002) were significantly higher whereas lymphocyte (P=0.008) and serum albumin (P<0.001) were significantly lower in non-survivor group compared to survivor group. Multivariate logistic regression analysis showed that NLR (odds ratio [OR]: 1.044, 95% confidence interval [CI]: 1.044-1.437, P=0.013), CAR (OR: 1.971, 95% CI: 1.327-2.930, P=0.001), and lactate level (OR: 1.268, 95% CI: 1.095-1.469, P=0.002) were independent predictors of mortality. Conclusions: We have demonstrated for the first time that CAR was an independent predictor of in-hospital mortality in OHCA patients.

scholarly journals The prognostic value of C-reactive protein to albumin ratio in patients with lung cancer

Medicine ◽  
2018 ◽  
Vol 97 (50) ◽  
pp. e13505 ◽  
Author(s):  
Tai-Bing Deng ◽  
Jing Zhang ◽  
Yong-Zhao Zhou ◽  
Wei-Min Li
Keyword(s):  
Lung Cancer ◽  
Prognostic Value ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein

scholarly journals Prognostic role of pre-treatment C-reactive protein/albumin ratio in esophageal cancer: a meta-analysis

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhenhua Liu ◽  
Hongtai Shi ◽  
Longyun Chen
Keyword(s):  
Esophageal Cancer ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Cochrane Library ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Pre Treatment

Abstract Background In recent years, the role of pre-treatment C-reactive protein/albumin ratio (CAR) in prognosis of esophageal cancer (EC) has been investigated by several studies. This meta-analysis aimed to provide a more accurate and objective assessment of the prognostic value of pre-treatment CAR in EC. Methods Studies assessing the role of pre-treatment CAR in prognosis of EC were searched from PubMed, Embase and the Cochrane Library (last update by April 16, 2019). The hazard ratios (HRs) of CAR and the corresponding 95% CIs for overall survival (OS) or cancer-specific survival (CSS) in EC were extracted for pooled analysis. Results A total of eight observational studies including 2255 patients were collected. The pooled analysis showed that high CAR was related to worse OS in EC (pooled HR = 1.81; 95% CI = 1.40–2.35; P < 0.001). Subgroup analyses showed that the negative correlation between the CAR and OS was consistently demonstrated in subgroups stratified by country, pathological type, and cut-off value (P < 0.05). However, there was no relation between CAR and OS in subgroup of patients receiving neoadjuvant chemotherapy at a proportion of 100% (HR = 1.15, 95% CI = 0.56–2.69; P = 0.715). In addition, high CAR was also related to worse CSS in EC (pooled HR = 2.61; 95% CI = 1.67–4.06; P < 0.001). Conclusions High pre-treatment CAR was an adverse prognostic factor for EC patients. More large-sample clinical trials are still needed to verify the prognostic value of pre-treatment CAR in EC.

scholarly journals Prognostic value of pretreatment C-reactive protein/albumin ratio in nasopharyngeal carcinoma

Medicine ◽  
2018 ◽  
Vol 97 (30) ◽  
pp. e11574 ◽  
Author(s):  
Xiaodi Yang ◽  
Hongjian Liu ◽  
Minfu He ◽  
Meitian Liu ◽  
Ge Zhou ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prognostic Value ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein

scholarly journals Admission C-reactive protein concentrations are associated with unfavourable neurological outcome after out-of-hospital cardiac arrest

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christoph Schriefl ◽  
Christian Schoergenhofer ◽  
Michael Poppe ◽  
Christian Clodi ◽  
Matthias Mueller ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Neurological Outcome ◽  
Odds Ratio ◽  
Cerebral Performance Category ◽  
Spontaneous Circulation ◽  
C Reactive Protein ◽  
Extracorporeal Cardiopulmonary Resuscitation ◽  
Crude Odds Ratio ◽  
Reactive Protein ◽  
Hospital Cardiac Arrest

AbstractWhether admission C-reactive protein (aCRP) concentrations are associated with neurological outcome after out-of-hospital cardiac arrest (OHCA) is controversial. Based on established kinetics of CRP, we hypothesized that aCRP may reflect the pre-arrest state of health and investigated associations with neurological outcome. Prospectively collected data from the Vienna Clinical Cardiac Arrest Registry of the Department of Emergency Medicine were analysed. Adults (≥ 18 years) who suffered a non-traumatic OHCA between January 2013 and December 2018, without return of spontaneous circulation or extracorporeal cardiopulmonary resuscitation therapy were eligible. The primary endpoint was a composite of unfavourable neurologic function or death (defined as Cerebral Performance Category 3–5) at 30 days. Associations of CRP levels drawn within 30 min of hospital admission were assessed using binary logistic regression. ACRP concentrations were overall low in our population (n = 832), but higher in the unfavourable outcome group [median: 0.44 (quartiles 0.15–1.44) mg/dL vs. 0.26 (0.11–0.62) mg/dL, p < 0.001]. The crude odds ratio for higher aCRP concentrations was 1.19 (95% CI 1.10–1.28, p < 0.001, per mg/dL) to have unfavourable neurological outcome. After multivariate adjustment for traditional prognostication markers the odds ratio of higher aCRP concentrations was 1.13 (95% CI 1.04–1.22, p = 0.002). Sensitivity of aCRP was low, but specificity for unfavourable neurological outcome was 90% for the cut-off at 1.5 mg/dL and 97.5% for 5 mg/dL CRP. In conclusion, high aCRP levels are associated with unfavourable neurological outcome at day 30 after OHCA.

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