An injectable metal nanoparticle containing cellulose derivative‐based hydrogels: Evaluation of antibacterial and in vitro‐vivo wound healing activity in children with burn injuries

Honey and propolis are natural substances produced by Apis mellifera that contain flavonoids, phenolic acids, and several other phytochemicals. The aim of this study was to phytochemically characterize three different types of honey and propolis, both separately and mixed, and to evaluate their wound-healing activity. Total phenolic compounds and flavonoids were determined using the Folin–Ciocalteu’s and aluminum chloride colorimetric methods, respectively. The antioxidant activity was evaluated by both the DPPH free radical scavenging assay and β-carotene bleaching test, and the anti-inflammatory activity was determined by a protein denaturation method. To evaluate the wound-healing activity of the samples, NHDF cells were subjected to a wound scratch assay. The obtained results showed that dark-brown honey presents a higher concentration of phenolic compounds and flavonoids, as well as higher antioxidant and anti-inflammatory activities. Propolis samples had the highest concentrations in bioactive compounds. Examining the microscopic images, it was possible to verify that the samples promote cell migration, demonstrating the wound-healing potential of honey and propolis.

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Evaluation of dermal wound healing activity and in vitro antibacterial and antioxidant activities of a new exopolysaccharide produced by Lactobacillus sp.Ca 6

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2017.05.017 ◽

2017 ◽

Vol 103 ◽

pp. 194-201 ◽

Cited By ~ 19

Author(s):

Imen Trabelsi ◽

Naourez Ktari ◽

Sirine Ben Slima ◽

Mehdi Triki ◽

Sana Bardaa ◽

...

Keyword(s):

Wound Healing ◽

Antioxidant Activities ◽

Dermal Wound Healing ◽

Dermal Wound ◽

Wound Healing Activity

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Investigation of Antioxidant and In Vitro Wound Healing Activity of Fulvic Acid

Journal of the Institute of Science and Technology ◽

10.21597/jist.509971 ◽

2019 ◽

pp. 1316-1326 ◽

Cited By ~ 1

Author(s):

Özlem Sultan Aslantürk ◽

Tülay Aşkın Çelik ◽

Yusuf Mert Sönmez

Keyword(s):

Wound Healing ◽

Fulvic Acid ◽

Wound Healing Activity

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IN VITRO ANTIOXIDANT ACTIVITY AND WOUND HEALING ACTIVITY OF WHEATGRASS BY 1,1- DIPHENYL, 2 PICRYLHYDRAZYL METHOD

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i12.27705 ◽

2018 ◽

Vol 11 (12) ◽

pp. 170

Author(s):

Veermaneni Alekhya ◽

Thiyagarajan Deepan ◽

Magharla Dasaratha Dhanaraju

Keyword(s):

Antioxidant Activity ◽

Wound Healing ◽

Skin Diseases ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Wheat Plant ◽

Wide Range ◽

Wound Healing Activity ◽

In Vitro Antioxidant Activity

Objective: This study was designed to evaluate in vitro antioxidant activity and wound healing activity in Triticum aestivum (wheat grass).Methods: T. aestivum commonly known as Wheatgrass had a wide range of health benefits among the young grass of common wheat plant components includes chlorophyll, flavonoids, and Vitamins A, C, and E. Wheatgrass is used in Folklore medicine for treatment of skin diseases and wound healing. In our present study, petroleum ether, ethanol and aqueous extracts of T. aestivum have been evaluated for in vitro antioxidant activity and wound healing activity by 1,1- diphenyl, 2 Picrylhydrazyl radical scavenging activity, and Chick chorioallantoic method, respectively.Results: The results of both the assay showed that all the extracts of T. aestivum have significant antioxidant and wound healing activity on dose-dependent manner.Conclusion: The wheatgrass has antioxidant and wound healing activity.

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Phytochemical characterization and in vitro wound healing activity of leaf extracts from Combretum mucronatum Schum. & Thonn.: Oligomeric procyanidins as strong inductors of cellular differentiation

Journal of Ethnopharmacology ◽

10.1016/j.jep.2015.06.008 ◽

2015 ◽

Vol 174 ◽

pp. 628-636 ◽

Cited By ~ 12

Author(s):

E. Kisseih ◽

M. Lechtenberg ◽

F. Petereit ◽

J. Sendker ◽

D. Zacharski ◽

...

Keyword(s):

Wound Healing ◽

Cellular Differentiation ◽

Leaf Extracts ◽

Wound Healing Activity

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Wound Healing Activity of α-Pinene and α-Phellandrene

Molecules ◽

10.3390/molecules26092488 ◽

2021 ◽

Vol 26 (9) ◽

pp. 2488

Author(s):

Judith Salas-Oropeza ◽

Manuel Jimenez-Estrada ◽

Armando Perez-Torres ◽

Andres Eliu Castell-Rodriguez ◽

Rodolfo Becerril-Millan ◽

...

Keyword(s):

Wound Healing ◽

Healing Process ◽

Folk Medicine ◽

Fibroblast Cell ◽

In Vitro Tests ◽

Low Concentrations ◽

In Vivo Tests ◽

Wound Healing Activity

Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. Recently, it was shown that the essential oil (EO) of B. morelensis has wound healing activity, accelerating cutaneous wound closure and generating scars with good tensile strength. α-pinene (PIN) and α-phellandrene (FEL) are terpenes that have been found in this EO, and it has been shown in different studies that both have anti-inflammatory activity. The aim of this study was to determine the wound healing activity of these two terpenes. The results of in vitro tests demonstrate that PIN and FEL are not cytotoxic at low concentrations and that they do not stimulate fibroblast cell proliferation. In vivo tests showed that the terpenes produce stress-resistant scars and accelerate wound contraction, due to collagen deposition from the early stages, in wounds treated with both terpenes. Therefore, we conclude that both α-pinene and α-phellandrene promote the healing process; this confirms the healing activity of the EO of B. morelensis, since having these terpenes as part of its chemical composition explains part of its demonstrated activity.

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AN in vitro STUDY OF WOUND HEALING ACTIVITY OF Ficus deltoidea LEAF EXTRACT

Jurnal Teknologi ◽

10.11113/jt.v77.6008 ◽

2015 ◽

Vol 77 (3) ◽

Author(s):

Nurul Ain Aqilla Wan Mustaffa ◽

Rosnani Hasham ◽

Mohamad Roji Sarmidi

Keyword(s):

Wound Healing ◽

Leaf Extract ◽

Wound Closure ◽

In Vitro Study ◽

Human Skin Fibroblast ◽

Dependent Manner ◽

Ficus Deltoidea ◽

Migration Assay ◽

Wound Healing Activity

Ficus deltoidea (Mas Cotek) is one of the popular herbs that has been used traditionally to alleviate illnesses. The present study aimed to investigate the in vitro wound healing activity of F. deltoidea leaf extract on skin cell. Cell proliferative and migration assay were done on the Human Skin Fibroblast cell (HSF 1184) which were treated with different concentrations of F. deltoidea leaf extract. The data of wound closure were collected at time intervals of 0, 6, 12 and 24 hours and analyzed using ImageJ™ software. MTT assay revealed that the F. deltoidea leaf extract could induce cell proliferation at a dose dependent manner. F. deltoidea leaf extract significantly accelerated the wound closure process in comparison to cells treated with ascorbic acid and untreated cells in scratch assay. Following 24 hours of incubation, cells treated with 50 mg/mL of F. deltoidea leaf extract showed remarkable proliferative and wound closure effect with 143.67% and 5.96%, respectively as compared to other concentrations. Collectively, these findings suggested that F. deltoidea leaf extract possesses wound healing potential and may be useful for the development of efficient wound healing drug.

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