Perfusion magnetic resonance imaging and magnetic resonance spectroscopy of cerebral gliomas showing imperceptible contrast enhancement on conventional magnetic resonance imaging

2004 ◽  
Vol 48 (3) ◽  
pp. 324-332 ◽  
Author(s):  
A Batra ◽  
RP Tripathi ◽  
AK Singh
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Contrast Enhancement ◽  
Perfusion Magnetic Resonance Imaging ◽  
Resonance Spectroscopy ◽  
Conventional Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Conventional Magnetic Resonance ◽  
Cerebral Gliomas

Very Late Frontal Relapse of Medulloblastoma Mimicking a Meningioma in an Adult: Usefulness of 1H Magnetic Resonance Spectroscopy and Diffusion-perfusion Magnetic Resonance Imaging for Preoperative Diagnosis: Case Report

Neurosurgery ◽  
2006 ◽  
Vol 58 (4) ◽  
pp. E789-E789 ◽  
Author(s):  
Emmanuel Jouanneau ◽  
Rafael Alfonso Guzman Tovar ◽  
Claude Desuzinges ◽  
Didier Frappaz ◽  
Guy Louis-Tisserand ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Diffusion Imaging ◽  
Magnetic Resonance Images ◽  
Perfusion Magnetic Resonance Imaging ◽  
Metabolic Imaging ◽  
Resonance Spectroscopy ◽  
Resonance Imaging ◽  
Apparent Diffusion Coefficient Value

Abstract OBJECTIVE AND IMPORTANCE: We present a rare case of very long-term medulloblastoma relapse in an adult patient and discuss the pattern of recurrence and metabolic imaging of the tumor. CLINICAL PRESENTATION: A 45-year-old man was referred for evaluation of a frontobasal midline tumor 21 years after treatment of a cerebellar medulloblastoma by surgery followed by chemotherapy and craniospinal radiotherapy. Magnetic resonance images were suggestive of a meningioma. Several hypotheses were discussed, such as other radio-induced tumors, sarcomas, high-grade gliomas, or lymphomas (previous chemotherapy) and even recurrence of medulloblastoma. Preoperative exploration included 1H magnetic resonance single-voxel spectroscopy (35 and 135 ms echo time), diffusion imaging, and perfusion magnetic resonance imaging. INTERVENTION: On magnetic resonance spectroscopy, N-acetyl-aspartate and an elevated choline/creatine ratio were retrieved, with a huge unidentified peak at 1.27 parts per million (ppm). Myoinositol signal was present at both echo times. On diffusion imaging, the tumor appeared hyperintense, with a low apparent diffusion coefficient value of 0.689. In the perfusion study, the maximal relative cerebral blood volume was 2. Metabolic imaging favored the diagnosis of medulloblastoma over the initially suspected diagnosis of meningioma. The patient underwent complete removal of the tumor that was confirmed to be a metastasis of his primary medulloblastoma. The postoperative course was uneventful, and complementary courses of radiotherapy and chemotherapy were planned. CONCLUSION: Late relapse should be considered, even after several decades, on occurrence of a second intracranial tumor in this context. Our observation validates the clinical interest of preoperative metabolic imaging for brain tumors with distinctive pattern.

Voxelwise analysis of conventional magnetic resonance imaging to predict future disability in early relapsing–remitting multiple sclerosis

2012 ◽  
Vol 18 (11) ◽  
pp. 1585-1591 ◽  
Author(s):  
Delphine Wybrecht ◽  
Françoise Reuter ◽  
Wafaa Zaaraoui ◽  
Anthony Faivre ◽  
Lydie Crespy ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Physical Disability ◽  
Conventional Magnetic Resonance Imaging ◽  
Global Approach ◽  
Resonance Imaging ◽  
Conventional Magnetic Resonance ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Changes

Background: The ability of conventional magnetic resonance imaging (MRI) to predict subsequent physical disability and cognitive deterioration after a clinically isolated syndrome (CIS) is weak. Objectives: We aimed to investigate whether conventional MRI changes over 1 year could predict cognitive and physical disability 5 years later in CIS. We performed analyses using a global approach (T2 lesion load, number of T2 lesions), but also a topographic approach. Methods: This study included 38 patients with a CIS. At inclusion, 10 out of 38 patients fulfilled the 2010 revised McDonald’s criteria for the diagnosis of multiple sclerosis. Expanded Disability Status Scale (EDSS) evaluation was performed at baseline, year 1 and year 5, and cognitive evaluation at baseline and year 5. T2-weighted MRI was performed at baseline and year 1. We used voxelwise analysis to analyse the predictive value of lesions location for subsequent disability. Results: Using the global approach, no correlation was found between MRI and clinical data. The occurrence or growth of new lesions in the brainstem was correlated with EDSS changes over the 5 years of follow-up. The occurrence or growth of new lesions in cerebellum, thalami, corpus callosum and frontal lobes over 1 year was correlated with cognitive impairment at 5 years. Conclusion: The assessment of lesion location at the first stage of multiple sclerosis may be of value to predict future clinical disability.

Comparison of Diagnostic Accuracy of Magnetic Resonance Spectroscopy with Conventional Magnetic Resonance Imaging for Brain Tumors and Correlation with Histopathology as Gold Standard

2021 ◽  
Vol 15 (9) ◽  
pp. 4009-4011
Author(s):  
Saulat Sarfraz ◽  
Mahwish Farzana
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Tumors ◽  
Diagnostic Accuracy ◽  
Gold Standard ◽  
Age Groups ◽  
Resonance Spectroscopy ◽  
Resonance Imaging ◽  
Conventional Mri

Background: In spite of recent advances in the use of diagnostic imaging modalities none of them has a hundred percent accuracy. So, misdiagnosis still occurs. Many trials are being done to evaluate the accuracy of these tools individually or in combination. The most useful investigation is MRI which broadly gives information of lesion as well its relationship with surrounding structures. While magnetic resonance spectroscopy further characterizes the lesion into benign or malignant. So this study is bit superior giving more details. By enlarge histopathology is gold standard for ultimate diagnosis. However these radiological investigations are extremely important for preoperative planning as well management of the lesion. In this study we compare the diagnostic accuracy of Magnetic Resonance Spectroscopy (MRS) with conventional MRI (Magnetic Resonance Imaging) sequences for diagnosis of brain tumors keeping histopathology as gold standard. Methods: The study was performed in 150 clinically suspected cases which were referred to Radiology Department from OPD, Indoor, Emergency and private sources from outside the hospital. Results: Majority 85(56.7%) were adult males and 65(43.3%) were adult females. The study was divided into two major age groups. There were 33cases (22%) with average age 20-35 years. The other age group 36-50 years had 40(26.7%) Majority of the cases 77(51.3%) were of average >50 years of age. The higher age groups showed a female dominance. Histopathology of 100(66.7%) cases confirmed positive and 50(33.3%) negative for MR Spectroscopy. On comparison of conventional MRI with contrast, and Histopathology it was observed that the sensitivity of MRI was 74.0% and the specificity 82.0%.The positive and negative predictive values gave a lower accuracy rate of 76.6%. Conclusion: The conclusion of our study is that MRS is a rigorous, non-invasive, safe and convenient imaging modality for the evaluation of brain tumors as compared to MRI. Keywords: Brain tumors, MRI, MRS, Histopathology

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