The effect of cyclosporin A on proliferation and differentiation-associated antigens of normal human skin xenografted onto nude mice

1990 ◽  
Vol 1 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Jean Kanitakis ◽  
Atsumichi Urabe ◽  
Marek Haftek ◽  
Jean Thivolet
Keyword(s):  
Cyclosporin A ◽  
Human Skin ◽  
Nude Mice ◽  
Normal Human Skin ◽  
Proliferation And Differentiation ◽  
Normal Human

Histological and ultrastructural effects of cyclosporin A on normal human skin xenografted on to nude mice

1990 ◽  
Vol 416 (6) ◽  
pp. 505-511 ◽  
Author(s):  
Jean Kanitakis ◽  
Ana Ramirez-Bosca ◽  
Marek Haftek ◽  
Jean Thivolet
Keyword(s):  
Cyclosporin A ◽  
Human Skin ◽  
Nude Mice ◽  
Normal Human Skin ◽  
Normal Human

Ultraviolet B induces hyperproliferation and modification of epidermal differentiation in normal human skin grafted on to nude mice

2004 ◽  
Vol 150 (4) ◽  
pp. 658-667 ◽  
Author(s):  
S. Del Bino ◽  
C. Vioux ◽  
P. Rossio-Pasquier ◽  
A. Jomard ◽  
M. Demarchez ◽  
...  
Keyword(s):  
Human Skin ◽  
Nude Mice ◽  
Ultraviolet B ◽  
Epidermal Differentiation ◽  
Normal Human Skin ◽  
Normal Human

The Effect of Practolol, In Vitro Generated Metabolites of Practolol and Chemical Analogues on the Rate of Growth of Human Skin Fibroblasts

1984 ◽  
Vol 12 (2) ◽  
pp. 89-97
Author(s):  
Graham R. Elliott ◽  
H.E. Amos ◽  
James W. Bridges
Keyword(s):  
Human Skin ◽  
Psoriasis Patient ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Cell Type ◽  
Normal Human Skin ◽  
Rate Of Growth ◽  
Structural Analogues ◽  
Normal Human

The rate of growth of normal human skin fibroblasts was inhibited in a dose related, reversible, fashion by practolol (N-4-(2-hydroxy)-3 (1-methyl)-aminopropoxyphenylacetamine) (ID50 1.35 ± 0.14 x 10-3M), propranolol (1-(isopropylamino)-3(1-naphthyl-oxy)-2-propranolol) (ID50 0.145 ± 0.02 x 10-3M) and paracetamol (N-(4-hydroxyphenyl) acetamide) (ID50 0.85 ± 0.2 x 10-3M). Skin fibroblasts isolated from a psoriasis patient were more sensitive towards practolol (ID50 0.48 ± 0.14 x 10-3M) and propranolol (ID50 0.032 ± 0.002 x 10-3M), but less sensitive towards paracetamol (ID50 1.3 ± 0.07 x 10-3M). In vitro generated metabolites of practolol, using normal or Arochlor 1254-pretreated hamster liver preparations, and structural analogues of practolol had no effect upon the growth of either cell type.

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