Thyroid Hormones and Thyroxine-binding Globulin in Relation to Liver Function and Serum Testosterone in Men with Alcoholic Cirrhosis

2009 ◽  
Vol 224 (4) ◽  
pp. 367-373 ◽  
Author(s):  
ULRIK BECKER ◽  
CHRISTIAN GLUUD ◽  
PAUL BENNETT
Keyword(s):  
Liver Function ◽  
Thyroid Hormones ◽  
Alcoholic Cirrhosis ◽  
Serum Testosterone ◽  
Thyroxine Binding Globulin

Transient Prealbumin- Associated Hyperthyroxinemia in TSH-Producing Pituitary Adenoma

1990 ◽  
Vol 29 (01) ◽  
pp. 40-43 ◽  
Author(s):  
W. Langsteger ◽  
P. Költringer ◽  
P. Wakonig ◽  
B. Eber ◽  
M. Mokry ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Pituitary Adenoma ◽  
Thyroid Hormones ◽  
Protein Binding ◽  
Alpha Subunit ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
Free Thyroid Hormones ◽  
Transmission Computed Tomography

This case report describes a 38-year-old male who was hospitalized for further clarification of clinically mild hyperthyroidism. His increased total hormone levels, the elevated free thyroid hormones and the elevated basal TSH with blunted response to TRH strongly suggested a pituitary adenoma with inappropriate TSH incretion. Transmission computed tomography showed an intrasellar expansion, 16 mm in diameter. The neoplastic TSH production was confirmed by an elevated alpha-subunit and a raised molar alpha-sub/ATSH ratio. However, T4 distribution on prealbumin (PA, TTR), albumin (A) and thyroxine binding globulin (TBG) showed a clearly increased binding to PA (39%), indicating additional prealbumin-associated hyperthyroxinemia. The absolute values of PA, A and TBG were within the normal range. After removal of the TSH-producing adenoma, basal TSH, the free thyroid hormones and T4 binding to prealbumin returned to normal. Therefore, the prealbumin-associated hyperthyroxinemia had to be interpreted as a transitory phenomenon related to secondary hyperthyroidism (T4 shift from thyroxine binding globulin to prealbumin) rather than a genetically conditioned anomaly of protein binding.

ALTERATIONS IN CIRCULATING THYROID HORMONES AND THYROXINE BINDING GLOBULIN IN CHRONIC ALCOHOLISM

1981 ◽  
Vol 14 (2) ◽  
pp. 113-118 ◽  
Author(s):  
J. GEURTS ◽  
N. DEMEESTER-MIRKINE ◽  
D. GLINOER ◽  
T. PRIGOGINE ◽  
M. FERNANDEZ-DEVILLE ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Chronic Alcoholism ◽  
Thyroxine Binding Globulin

Splanchnic and renal extraction of circulating type III procollagen aminoterminal propeptide in patients with normal liver function and in patients with alcoholic cirrhosis

Hepatology ◽  
1990 ◽  
Vol 11 (6) ◽  
pp. 957-963 ◽  
Author(s):  
Kirsten D. Bentsen ◽  
Jens H. Henriksen ◽  
Flemming Bendtsen ◽  
Kim Hørslev-Petersen ◽  
Ib Lorenzen
Keyword(s):  
Liver Function ◽  
Alcoholic Cirrhosis ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Type Iii ◽  
Type Iii Procollagen

Quantitative tests of liver function reveal compromised liver function in patients with alcoholic VS. non-alcoholic cirrhosis matched for child pugh grade

2000 ◽  
Vol 118 (4) ◽  
pp. A954
Author(s):  
Christoph Herold ◽  
Klaus Wehr ◽  
Hans T. Schneider ◽  
Detlef Schuppan ◽  
Eckhart G. Hahn
Keyword(s):  
Liver Function ◽  
Alcoholic Cirrhosis

scholarly journals Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Datis Kharrazian ◽  
Martha Herbert ◽  
Aristo Vojdani
Keyword(s):  
Thyroid Hormones ◽  
Dietary Protein ◽  
Polyclonal Antibodies ◽  
Thyroid Peroxidase ◽  
Immune Reactivity ◽  
Dietary Proteins ◽  
Thyroxine Binding Globulin ◽  
Autoimmune Thyroid ◽  
Target Sites ◽  
Thyroid Axis

Many hypothyroid and autoimmune thyroid patients experience reactions with specific foods. Additionally, food interactions may play a role in a subset of individuals who have difficulty finding a suitable thyroid hormone dosage. Our study was designed to investigate the potential role of dietary protein immune reactivity with thyroid hormones and thyroid axis target sites. We identified immune reactivity between dietary proteins and target sites on the thyroid axis that includes thyroid hormones, thyroid receptors, enzymes, and transport proteins. We also measured immune reactivity of either target specific monoclonal or polyclonal antibodies for thyroid-stimulating hormone (TSH) receptor, 5′deiodinase, thyroid peroxidase, thyroglobulin, thyroxine-binding globulin, thyroxine, and triiodothyronine against 204 purified dietary proteins commonly consumed in cooked and raw forms. Dietary protein determinants included unmodified (raw) and modified (cooked and roasted) foods, herbs, spices, food gums, brewed beverages, and additives. There were no dietary protein immune reactions with TSH receptor, thyroid peroxidase, and thyroxine-binding globulin. However, specific antigen-antibody immune reactivity was identified with several purified food proteins with triiodothyronine, thyroxine, thyroglobulin, and 5′deiodinase. Laboratory analysis of immunological cross-reactivity between thyroid target sites and dietary proteins is the initial step necessary in determining whether dietary proteins may play a potential immunoreactive role in autoimmune thyroid disease.

scholarly journals A Case of Thyrotoxicosis-induced Anemia After the Onset of Painless Thyroiditis in a Patient With Pancreatic Diabetes Mellitus: Profile of Hemoglobin, Thyroid Hormones, Soluble IL-2 Receptor, LDL-C, HDL-C and Liver Function.

2020 ◽  
Author(s):  
Ichiro Komiya ◽  
Noriharu Yagi ◽  
Takeaki Tomoyose ◽  
Gen Ouchi ◽  
Tamio Wakugami
Keyword(s):  
Liver Function ◽  
Thyroid Hormones ◽  
Disease Onset ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Normocytic Anemia ◽  
Free Triiodothyronine ◽  
Pancreatic Diabetes ◽  
First Case ◽  
Painless Thyroiditis

Abstract Background: There have been several reports of secondary anemia associated with Graves' disease. There are no reports of secondary anemia resulting from thyrotoxicosis due to painless thyroiditis (silent thyroiditis). We report the case of a patient with pancreatic diabetes who developed normocytic anemia caused by thyrotoxicosis due to painless thyroiditis.Case presentation: The patient was a 37-year-old man who visited the hospital complaining of fatigue, palpitations, and dyspnea. His hemoglobin was 110 g/l, and mean corpuscular volume was 81.5 fl. His free thyroxine (FT4) was high, at 1.004 pmol/l, the free triiodothyronine (FT3) was high, at 27.49 pmol/l, TSH was <0.01 mIU/l, and TSH receptor antibody was negative. Soluble IL-2 receptor (sIL-2R) was high, at 1,340 U/ml, low-density lipoprotein cholesterol (LDL-C) was 0.78 mmol/l, and high-density lipoprotein cholesterol (HDL-C) was 0.75 mmol/l. Propranolol was prescribed and followed up. Thyroid hormones, sIL-2R, LDL-C, and HDL-C had almost normalized by 8 weeks after onset. Anemia completely disappeared by 12 weeks after disease onset. Slight increases in liver enzyme levels and a decrease in serum albumin were observed, and recovered later than normalization of thyroid function and cholesterol levels. He developed mild hypothyroidism and was treated with L-thyroxine at 24 weeks.Conclusions: This is the first case report of transient secondary anemia associated with thyrotoxicosis due to painless thyroiditis. Changes in sIL-2R, HDL-C, LDL-C and liver function were also observed during the clinical course of thyrotoxicosis and anemia, suggesting the autoimmune processes in thyroid gland, bone marrow and liver.

Sorafenib for the treatment of patients with advanced hepatocellular carcinoma and alcoholic cirrhosis.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 352-352
Author(s):  
P. Giovanis ◽  
V. Vincenzi ◽  
C. Manuppelli ◽  
R. Berletti ◽  
M. Marcante ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Function ◽  
Disease Progression ◽  
Median Time ◽  
Alcoholic Cirrhosis ◽  
Function Class ◽  
Median Number ◽  
Hcv Infection ◽  
Advanced Hepatocellular Carcinoma ◽  
Sorafenib Treatment

352 Background: Hepatocellular carcinoma (HCC) from alcoholic cirrhosis, associated or not with chronic hepatitis C virus (HCV) infection, is a particularly severe liver disease. Scanty and inconsistent data concerning the efficacy of sorafenib in patients (pts) with this disease are available. Methods: Since February 2009 we screened 26 Child-Pugh liver function class A pts bearing the above characteristics. Sixteen of them (61.5%), 15 males and 1 female with median age of 69 years (range 54-79), received 400 mg sorafenib b.i.d. Predominant cause of HCC was alcohol consumption in 13 pts (81.2%), associated with chronic HCV infection in 2 pts (12.5%), and hemosiderosis in 1 pt (6.2%). All pts suffered from multiple comorbidities, and 3 had been previously treated for Burkitt lymphoma, bladder and breast cancer. One pt with prostate cancer was on treatment with androgen blockade. Median number of concomitant medications was 4 (range 2-9). Four pts never received locoregional treatment, and none had received previous antineoplastic therapy. Results: Twelve pts (73%) discontinued sorafenib after a median time of 2 months (range 2-6). The reasons for treatment discontinuation were disease progression (4 pts), liver function deterioration (5 pts), and mild gastrointestinal adverse events (2 pts): 1 pt refused sorafenib treatment after 15 days. 2/4 patients still on treatment with sorafenib at 7, 8, 11, and 18 months showed partial response (RECIST criteria). Seven pts (40%) died because of disease progression at a median time of 5.5 months (range 2-9) and at a median overall survival time of 36 months from diagnosis (range 2-84). Conclusions: Treatment with sorafenib in pts affected by HCC and alcoholic cirrhosis seems effective and well tolerated with high-level compliance. The most common cause of discontinuation was progression of disease and liver function deterioration. No significant financial relationships to disclose.

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