scholarly journals Expression of Drug Resistance-related Genes in Head and Neck Squamous Cell Carcinoma and Normal Mucosa

2000 ◽  
Vol 91 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Shitau Hirata ◽  
Osamu Katoh ◽  
Tetsuya Oguri ◽  
Hiromitsu Watanabe ◽  
Koji Yajin
Keyword(s):  
Drug Resistance ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Normal Mucosa ◽  
Neck Squamous Cell Carcinoma

Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma

Head & Neck ◽  
2011 ◽  
Vol 34 (11) ◽  
pp. 1542-1550 ◽  
Author(s):  
Sébastien Van der Vorst ◽  
Anne-France Dekairelle ◽  
Birgit Weynand ◽  
Marc Hamoir ◽  
Jean-Luc Gala
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Functional Activity ◽  
Normal Mucosa ◽  
Neck Squamous Cell Carcinoma

scholarly journals Expression and Prognostic Value of IFIT1 and IFITM3 in Head and Neck Squamous Cell Carcinoma

2020 ◽  
Vol 153 (5) ◽  
pp. 618-629
Author(s):  
Hao Li ◽  
Lei-Lei Yang ◽  
Cong-Cong Wu ◽  
Yao Xiao ◽  
Liang Mao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
T Cell Activation ◽  
Squamous Cell ◽  
Cell Activation ◽  
Transmembrane Protein ◽  
Normal Mucosa ◽  
Neck Squamous Cell Carcinoma ◽  
Type I

Abstract Objectives Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) and interferon-induced transmembrane protein 3 (IFITM3) are commonly induced by type I interferon. The study aims to investigate the expression and clinical significance of IFIT1 and IFITM3 in head and neck squamous cell carcinoma (HNSCC). Methods Immunohistochemistry was applied on tissue microarray to reveal IFIT1 and IFITM3 expression in 275 HNSCC, 69 dysplasia, and 42 normal mucosa samples. The clinicopathologic features associated with IFIT1 and IFITM3 expression in HNSCC patients were analyzed. Results IFIT1 and IFITM3 were highly expressed in HNSCC tissues. High expression of IFIT1 and IFITM3 predicts a negative prognosis for patients (P < .01). IFIT1 and IFITM3 expression was associated with programmed cell death ligand 1, B7-H4, V-domain Ig suppressor of T-cell activation, indoleamine 2,3-dioxygenase, and macrophage marker immunoreactivity. Conclusions IFIT1 and IFITM3 were overexpressed in HNSCC and indicated poor prognoses for patients with HNSCC. IFIT1 and IFITM3 expression was correlated with several immune checkpoint molecules and tumor-associated macrophage markers.

Expression of the Krüppel-type zinc finger gene, ZK7, in head and neck squamous cell carcinoma and normal mucosa

2002 ◽  
Vol 185 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Nobuyuki Miyake ◽  
Osamu Katoh ◽  
Shitau Hirata ◽  
Shinji Kimura ◽  
Hiromitsu Watanabe ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Zinc Finger ◽  
Squamous Cell ◽  
Normal Mucosa ◽  
Neck Squamous Cell Carcinoma ◽  
Zinc Finger Gene

Assessment of oxidative stress in tumors and histologically normal mucosa from patients with head and neck squamous cell carcinoma

2013 ◽  
Vol 22 (6) ◽  
pp. 558-560 ◽  
Author(s):  
Didier Dequanter ◽  
Maureen Van de Velde ◽  
Vincent Nuyens ◽  
Nathalie Nagy ◽  
Paul Van Antwerpen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Normal Mucosa ◽  
Neck Squamous Cell Carcinoma

scholarly journals HIF-1α or HOTTIP/CTCF Promotes Head and Neck Squamous Cell Carcinoma Progression and Drug Resistance by Targeting HOXA9

2020 ◽  
Vol 20 ◽  
pp. 164-175 ◽  
Author(s):  
Qiang Sun ◽  
Shuai-Yuan Zhang ◽  
Jun-Fang Zhao ◽  
Xin-Guang Han ◽  
Hai-Bin Wang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

scholarly journals Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review

Cancers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 376 ◽  
Author(s):  
Sandra López-Verdín ◽  
Jesús Lavalle-Carrasco ◽  
Ramón Carreón-Burciaga ◽  
Nicolás Serafín-Higuera ◽  
Nelly Molina-Frechero ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Excision Repair ◽  
Dna Lesions ◽  
Neck Squamous Cell Carcinoma ◽  
Tumor Resistance ◽  
Base Excision

This manuscript provides an update to the literature on molecules with roles in tumor resistance therapy in head and neck squamous cell carcinoma (HNSCC). Although significant improvements have been made in the treatment for head and neck squamous cell carcinoma, physicians face yet another challenge—that of preserving oral functions, which involves the use of multidisciplinary therapies, such as multiple chemotherapies (CT) and radiotherapy (RT). Designing personalized therapeutic options requires the study of genes involved in drug resistance. This review provides an overview of the molecules that have been linked to resistance to chemotherapy in HNSCC, including the family of ATP-binding cassette transporters (ABCs), nucleotide excision repair/base excision repair (NER/BER) enzymatic complexes (which act on nonspecific DNA lesions generated by gamma and ultraviolet radiation by cross-linking and forming intra/interchain chemical adducts), cisplatin (a chemotherapeutic agent that causes DNA damage and induces apoptosis, which is a paradox because its effectiveness is based on the integrity of the genes involved in apoptotic signaling pathways), and cetuximab, including a discussion of the genes involved in the cell cycle and the proliferation of possible markers that confer resistance to cetuximab.

scholarly journals The roles of extracellular vesicles in the development, microenvironment, anticancer drug resistance, and therapy of head and neck squamous cell carcinoma

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Xueying Wang ◽  
Junnan Guo ◽  
Pingyang Yu ◽  
Lunhua Guo ◽  
Xionghui Mao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Immune Escape ◽  
Neck Squamous Cell Carcinoma ◽  
Bioactive Molecules ◽  
Malignant Tumours ◽  
Biological Behaviour

AbstractHead and neck squamous cell carcinoma (HNSCC) is one of the main malignant tumours affecting human health, mainly due to delayed diagnosis and high invasiveness. Extracellular vehicles (EVs) are membranous vesicles released by cells into the extracellular matrix that carry important signalling molecules and stably and widely exist in various body fluids, such as plasma, saliva, cerebrospinal fluid, breast milk, urine, semen, lymphatic fluid, synovial fluid, amniotic fluid, and sputum. EVs transport almost all types of bioactive molecules (DNA, mRNAs, microRNAs (miRNAs), proteins, metabolites, and even pharmacological compounds). These “cargoes” can act on recipient cells, reshaping the surrounding microenvironment and altering distant targets, ultimately affecting their biological behaviour. The extensive exploration of EVs has deepened our comprehensive understanding of HNSCC biology. In this review, we not only summarized the effect of HNSCC-derived EVs on the tumour microenvironment but also described the role of microenvironment-derived EVs in HNSCC and discussed how the “mutual dialogue” between the tumour and microenvironment mediates the growth, metastasis, angiogenesis, immune escape, and drug resistance of tumours. Finally, the clinical application of EVS in HNSCC was assessed.

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