scholarly journals Molecular docking analysis of the protein–protein interaction between RelA-associated inhibitor and tumor suppressor protein p53 and its inhibitory effect on p53 action

2008 ◽  
Vol 99 (3) ◽  
pp. 615-622 ◽  
Author(s):  
Keisuke Tomoda ◽  
Naoko Takahashi ◽  
Yurina Hibi ◽  
Kaori Asamitsu ◽  
Hirokazu Ishida ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Tumor Suppressor ◽  
Protein Interaction ◽  
Inhibitory Effect ◽  
Tumor Suppressor Protein ◽  
Docking Analysis ◽  
Tumor Suppressor Protein P53 ◽  
Protein Protein Interaction ◽  
Protein P53 ◽  
Molecular Docking Analysis

p53: An Attractive Therapeutic Target for Cancer

2020 ◽  
Vol 27 (22) ◽  
pp. 3706-3734 ◽  
Author(s):  
Krupa R. Patel ◽  
Hitesh D. Patel
Keyword(s):  
Tumor Suppressor ◽  
Negative Regulator ◽  
Tumor Suppressor Protein ◽  
Internal Factors ◽  
Tumor Suppressor Protein P53 ◽  
Protein Protein Interaction ◽  
Protein P53 ◽  
Regulator Protein ◽  
Cell Mutation ◽  
Attractive Therapeutic Target

Cancer is a leading cause of death worldwide. It initiates when cell cycle regulatory genes lose their function either by environmental and/or by internal factors. Tumor suppressor protein p53, known as “Guardian of genome”, plays a central role in maintaining genomic stability of the cell. Mutation of TP53 is documented in more than 50% of human cancers, usually by overexpression of negative regulator protein MDM2. Hence, reactivation of p53 by blocking the protein-protein interaction between the murine double minute 2 (MDM2) and the tumor suppressor protein p53 has become the most promising therapeutic strategy in oncology. Several classes of small molecules have been identified as potent, selective and efficient p53-MDM2 inhibitors. Herein, we review the druggability of p53-MDM2 inhibitors and their optimization approaches as well as clinical candidates categorized by scaffold type.

Human Metalloproteinase-1 (Collagenase-1) Is a Tumor Suppressor Protein p53 Target Gene

1999 ◽  
Vol 878 (1 INHIBITION OF) ◽  
pp. 638-641 ◽  
Author(s):  
YUBO SUN ◽  
YI SUN ◽  
LEONOR WENGER ◽  
JONI L. RUTTER ◽  
CONSTANCE E. BRINCKERHOFF ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Target Gene ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53 ◽  
P53 Target Gene

scholarly journals Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression

2018 ◽  
Vol 294 (1) ◽  
pp. 299-313 ◽  
Author(s):  
Min-Kyeong Kim ◽  
Ji-Yang Song ◽  
Dong-In Koh ◽  
Jin Young Kim ◽  
Masahiko Hatano ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
B Cell ◽  
Negative Regulation ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Caspase 1 ◽  
Protein P53
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