Minimum alveolar concentration for halothane in children with cerebral palsy and severe mental retardation

Anaesthesia ◽  
1997 ◽  
Vol 52 (11) ◽  
pp. 1056-1060 ◽  
Author(s):  
F. J. Frei ◽  
M. H. Haemmerle ◽  
R. Brunner ◽  
C. Kern
PEDIATRICS ◽  
1996 ◽  
Vol 97 (2) ◽  
pp. 192-197
Author(s):  
Mauricio R. Delgado ◽  
Anthony R. Riela ◽  
Janith Mills ◽  
Alan Pitt ◽  
Richard Browne

Objective. The risk of seizure relapse after antiepileptic drug (AED) discontinuation in children has been reported to vary between 6% and 40%. It has been suggested that neurologic deficit and mental retardation are poor prognostic factors for seizure relapse after AED discontinuation. Because epileptic children with cerebral palsy (CP) have neurologic deficits, and many have mental retardation, it is important to know their risk for seizure relapse. Methods. AED treatment was discontinued in 65 children with CP and histories of epilepsy after 2 seizure-free years. All of the patients were followed until they had seizure relapses or for at least 2 years without seizures after AEDs were stopped. Multiple factors were analyzed for possible association with seizure relapse. Results. Twenty-seven patients (41.5%) had seizure relapses. Patients with spastic hemiparesis had the highest relapse rate (61.5%), and those with spastic diplegia had the lowest rate (14.3%). No other factor correlated significantly with the risk of seizure relapse. Conclusions. Discontinuation of AEDs in children with CP can, and should, be practiced when possible after patients have been seizure-free for at least 2 years. AED discontinuation in patients with spastic hemiparesis is significantly more likely to lead to seizure relapse than in patients with other CP types, but no other factor is yet known to increase the chance of relapse.


1989 ◽  
Vol 3 (2) ◽  
pp. 132-142 ◽  
Author(s):  
M. Bhat ◽  
K.B. Nelson

Developmental enamel defects in primary teeth have been found at least twice as frequently in children with cerebral palsy or mental retardation as in control children, and frequently also in children with sensori-neural hearing deficits. The developing tooth germ is sensitive to a range of systemic disturbances, some of which may also affect neurologic development. Because the enamel cannot recover once it is damaged, it may provide a repository of information on the timing and nature of insults potentially affecting other ectodermally derived structures, including the brain. This paper reviews the literature on developmental defects of enamel in primary teeth, asking whether these might be useful as biological markers of the timing and in some cases the nature of insults. Among systemic factors related to development of enamel that might also have implications for neurologic development are certain genetic disorders including tuberous sclerosis, premature birth, neonatal nutritional disturbances (especially hypocalcemia), viral infections (such as rubella and cytomegalovirus during gestation), thyroid disorders, and maternal diabetes. It is concluded that further research is warranted concerning whether developmental defects of dental enamel can be useful markers for the timing of intra-uterine or perinatal events associated with certain neurologic and sensory disorders of children.


2018 ◽  
Vol 11 (1) ◽  
pp. 25-31
Author(s):  
Erdoğan Kavlak ◽  
Güzin Kara ◽  
Fatih Tekin ◽  
Filiz Altuğ ◽  
Nusret Ök ◽  
...  

2019 ◽  
Vol 67 (2) ◽  
pp. 305-311 ◽  
Author(s):  
Enyao Li ◽  
Pengju Zhao ◽  
Jie Jian ◽  
Hong Wu ◽  
Shuibo Gao ◽  
...  

2017 ◽  
Vol 64 (2) ◽  
Author(s):  
Jan Józefczuk ◽  
Kasprzycka Wiktoria ◽  
Rafał Czarnecki ◽  
Alfreda Graczyk ◽  
Paweł Józefczuk ◽  
...  

We analyzed hair concentrations of magnesium (Mg), calcium (Ca), copper (Cu), zinc (Zn) and iron (Fe) in a group of 82 children with mental retardation, in which 9 patients suffered from epilepsy, 18 from Down's's syndrome and 55 from cerebral palsy.  Girls comprised little over 50% of the patients.In a group of boys with epilepsy we found a Mg, Ca, Cu and Fe deficiency, and normal level of Zn. In a group of girls with epilepsy, apart from low Fe concentration, a high levels of Ca, Mg, Zn, and Cu was noted.In girls with Down's syndrome a high or normal level of Ca, Mg, Zn and Cu was found, whereas Fe concentration presented itself in a non-characteristic way.Both boys and girls, in the group of children with cerebral palsy had  low Fe concentration, as well as low Cu levels was found in older patients. In this group we also noted high concentrations of Ca, Mg and Zn in girls and normal in boys.A high concentration of Ca in girls with cerebral palsy requires separate analysis.Obtained results could be useful as a guidance in the direction and determination of the amount of possible supplementation.


2020 ◽  
Vol 1 (1) ◽  
pp. 39-41
Author(s):  
Abbos Kadirov ◽  
◽  
Umida Omonova ◽  
Ulugbek Alimov ◽  
Kamola Rakhimova

The analysis of the studied scientific and medical literature has shown that there are no clear criteria for diagnosing mental retardation in children with cerebral palsy (CP). The Wexler test, which is used to determine the form of mental retardation, practically can not be used in the diagnosis of intellectual disabilities in cerebral palsy. All this dictates the need for additional research, development of criteria for diagnosing mental retardation in cerebral palsy


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